UCSF

ZINC84403437

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
January 31st, 2013 0 No

Popular Name: Topotecan Topotecan

Find On: PubMed — Wikipedia — Google

CAS Numbers: 119413-54-6 , 123948-87-8 , 123948-88-9 , [119413-54-6] , [123948-87-8]

Other Names:

(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-, (S)-; C23H23N3O5

tecan

10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; nsc609699

10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3`,4`:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride

119413-54-6; D02168; Hycamtin (TN); Nogitecan hydrochloride (JAN); Topotecan hydrochloride (USAN)

123948-87-8; C11158; Topotecan

123948-87-8; D08618; Hycamtin (TN); Topotecan (BAN)

9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin

9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin

CHEBI:9634

CPD000466344; SAM001246651; TOPOTECAN HCL

CPD000466344; SAM001246651; Topotecan Hydrochloride

E-89/001

Evotropin

FDA)

Hycamptamine

Hycamptin

Hycamtin

Hycamtin, NSC 609699

INN)

INN); Topotecan HCl (FDA

INN); Topotecan HCl (USAN

LS-187270

MFCD00866235

MFCD00870670

NA

NK-211

Nogitecan hydrochloride

NSC-609699

QA-7182

SK&F S-104864-A

SK&F-S-104864-A

SK&F-S-104864A

SK&F-S-104864A; SK-S-104864-A

SK-S-104864-A

Topotecan (BAN

Topotecan acetate

TOPOTECAN HCL

Topotecan Hydrochloride

Topotecan Hydrochloride (FDA

Topotecan lactone

Topotecan Lactone;Topotecane [INN-French];Topotecanum [INN-Latin]

topotecan; topotecane; topotecanum

TOPOTECANACETATE

Topotecane [INN-French]

Topotecanum [INN-Latin]

TPT

TTC

USAN)

USAN); Topotecan (BAN

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 8.61e-01 g/l DrugBank-approved
Indications antineoplastic KeyOrganics Bioactives
PUBCHEM_SUBSTANCE_COMMENT NCC_SAMPLE_SUPPLIER : Sequoia Research Products Ltd.; NCC_SUPPLIER_STRUCTURE_ID : SRP02510t; 1 hydrogen chloride NIH Clinical Collection via PubChem
UniProt Database Links S47A1_HUMAN; S47A1_MOUSE; S47A1_PONAB; S47A2_HUMAN; S47A2_PONAB; S47A2_RABIT; TYDP1_MOUSE ChEBI
PUBCHEM_SUBSTANCE_COMMENT SAMPLE_SUPPLIER: Sequoia Research Products Ltd.; SUPPLIER_STRUCTURE_ID: SRP02510t; SALT: 1 hydrogen chloride NIH Clinical Collection via PubChem
Target Topoisomerase Selleck Chemicals

Activity (Go SEA)

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.