| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 23rd, 2004 | 14 | No |
Popular Name: N-Benzylmaleimide N-Benzylmaleimide
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1631-26-1 , [1631-26-1]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.38 | 5.46 | -8.05 | 0 | 3 | 0 | 39 | 187.198 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| BP | 177 / 20 | TCI |
| melting_point | 65 - 67 | KeyOrganics |
| Melting_Point | 67-70? | Alfa-Aesar |
| Melting_Point | 67-70° | Alfa-Aesar |
| MP | 69-70° | Fluorochem |
| MP | 70 | TCI |
| MP | 70 - 72 | Enamine Building Blocks |
| MP | 70...72 | Enamine Building Blocks |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Purity | 99% | Fluorochem |
| Warnings | Corrosive | Matrix Scientific |
| Warnings | IRRITANT | Matrix Scientific |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GSK3A-2-E | Glycogen Synthase Kinase-3 Alpha (cluster #2 Of 3), Eukaryotic | Eukaryotes | 1000 | 0.60 | Binding ≤ 10μM |
| GSK3B-3-E | Glycogen Synthase Kinase-3 Beta (cluster #3 Of 7), Eukaryotic | Eukaryotes | 1000 | 0.60 | Binding ≤ 10μM |
| MGLL-2-E | Monoglyceride Lipase (cluster #2 Of 7), Eukaryotic | Eukaryotes | 5140 | 0.53 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GSK3A_HUMAN | P49840 | Glycogen Synthase Kinase-3 Alpha, Human | 1000 | 0.60 | Binding ≤ 1μM |
| GSK3B_HUMAN | P49841 | Glycogen Synthase Kinase-3 Beta, Human | 1000 | 0.60 | Binding ≤ 1μM |
| GSK3A_HUMAN | P49840 | Glycogen Synthase Kinase-3 Alpha, Human | 1000 | 0.60 | Binding ≤ 10μM |
| GSK3B_HUMAN | P49841 | Glycogen Synthase Kinase-3 Beta, Human | 1000 | 0.60 | Binding ≤ 10μM |
| MGLL_HUMAN | Q99685 | Monoglyceride Lipase, Human | 5140 | 0.53 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Acyl chain remodeling of DAG and TAG | |
| AKT phosphorylates targets in the cytosol | |
| APC truncation mutants have impaired AXIN binding | |
| Arachidonate production from DAG | |
| AXIN missense mutants destabilize the destruction complex | |
| Beta-catenin phosphorylation cascade | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CRMPs in Sema3A signaling | |
| Degradation of beta-catenin by the destruction complex | |
| disassembly of the destruction complex and recruitment of AXIN to the membrane | |
| Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | |
| misspliced GSK3beta mutants stabilize beta-catenin | |
| Regulation of HSF1-mediated heat shock response | |
| S33 mutants of beta-catenin aren't phosphorylated | |
| S37 mutants of beta-catenin aren't phosphorylated | |
| S45 mutants of beta-catenin aren't phosphorylated | |
| T41 mutants of beta-catenin aren't phosphorylated | |
| truncations of AMER1 destabilize the destruction complex | |
| XBP1(S) activates chaperone genes |
