UCSF

Bcl2-antagonist Of Cell Death (BAD), Human (54 Compounds)

Swissprot:
BAD_HUMAN
Stitch:
BAD_HUMAN
UniProt:
Q92934
ChEMBL:
CHEMBL3817
Reactome:
REACT_549
REACT_12564
REACT_330
REACT_147727
REACT_13638
PDB:
1G5J (DOCK)
BAD

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 54 3 1 1
Binding ≤ 1μM 27 1 0 0

Reactome Network (5)

Reactome ID Description Species
REACT_549 Activation of BAD and translocation to mitochondria Homo sapiens
REACT_12564 AKT phosphorylates targets in the cytosol Homo sapiens
REACT_330 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Homo sapiens
REACT_147727 Constitutive PI3K/AKT Signaling in Cancer Homo sapiens
REACT_13638 NRAGE signals death through JNK Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 46

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Uniprot Swissprot Chembl Description Number Shared
B2CL1_HUMAN Q07817 CHEMBL4625 Apoptosis Regulator Bcl-X, Human 2
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 46

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 46
MCL1_HUMAN Q07820 CHEMBL4361 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Human 6
B2CL1_HUMAN Q07817 CHEMBL4625 Apoptosis Regulator Bcl-X, Human 2
B2CL2_HUMAN Q92843 CHEMBL4677 Apoptosis Regulator Bcl-W, Human 2
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
B2L10_HUMAN Q9HD36 CHEMBL5988 Bcl-2-like Protein 10, Human 1
B2LA1_HUMAN Q16548 CHEMBL6044 Bcl-2-related Protein A1, Human 1
MDHC_PIG P11708 CHEMBL4048 Malate Dehydrogenase Cytoplasmic, Pig 1
MDHM_PIG P00346 CHEMBL3444 Malate Dehydrogenase Mitochondrial, Pig 1
Q0PJ46_PLAFA Q0PJ46 CHEMBL6071 Lactate Dehydrogenase, Plafa 1
Q6VVP7_PLAFA Q6VVP7 CHEMBL6072 Malate Dehydrogenase, Plafa 1

Most Common Rings