UCSF

Apoptosis Regulator Bcl-2, Human (198 Compounds)

Swissprot:
BCL2_HUMAN
Stitch:
BCL2_HUMAN
UniProt:
P10415
ChEMBL:
CHEMBL4860
Reactome:
REACT_549
REACT_330
REACT_75927
PDB:
1G5M (DOCK)
1GJH (DOCK)
1YSW (DOCK)
2O21 (DOCK)
2O22 (DOCK)
2O2F (DOCK)
2W3L (DOCK)
2XA0 (DOCK)
BCL2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 198 9 3 2
Binding ≤ 1μM 117 4 3 2
Functional ≤ 10μM 8 5 0 0

Reactome Network (3)

Reactome ID Description Species
REACT_549 Activation of BAD and translocation to mitochondria Homo sapiens
REACT_330 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Homo sapiens
REACT_75927 The NLRP1 inflammasome Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
BAD_HUMAN Q92934 CHEMBL3817 Bcl2-antagonist Of Cell Death (BAD), Human 46

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Uniprot Swissprot Chembl Description Number Shared
B2CL1_HUMAN Q07817 CHEMBL4625 Apoptosis Regulator Bcl-X, Human 58
BAD_HUMAN Q92934 CHEMBL3817 Bcl2-antagonist Of Cell Death (BAD), Human 46

The NLRP1 inflammasome

Uniprot Swissprot Chembl Description Number Shared
B2CL1_HUMAN Q07817 CHEMBL4625 Apoptosis Regulator Bcl-X, Human 58

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
BAD-1-E Bcl2-antagonist Of Cell Death (BAD) (cluster #1 Of 1), Eukaryotic 54 3 1 1
BCL2-1-E Apoptosis Regulator Bcl-2 (cluster #1 Of 2), Eukaryotic 198 9 3 2
BCL2-2-E Apoptosis Regulator Bcl-2 (cluster #2 Of 2), Eukaryotic 3 0 0 0
Uniprot Swissprot Chembl Description Number Shared
B2CL1_HUMAN Q07817 CHEMBL4625 Apoptosis Regulator Bcl-X, Human 58
BAD_HUMAN Q92934 CHEMBL3817 Bcl2-antagonist Of Cell Death (BAD), Human 46
MCL1_HUMAN Q07820 CHEMBL4361 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Human 45
B2LA1_HUMAN Q16548 CHEMBL6044 Bcl-2-related Protein A1, Human 19
MCL1_MOUSE P97287 CHEMBL5768 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog, Mouse 4
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 4
6PGD_HUMAN P52209 CHEMBL3404 6-phosphogluconate Dehydrogenase, Human 2
B2CL2_HUMAN Q92843 CHEMBL4677 Apoptosis Regulator Bcl-W, Human 2
G6PD_YEAST P11412 CHEMBL1075249 Glucose-6-phosphate 1-dehydrogenase, Yeast 2
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
Q72547_9HIV1 Q72547 CHEMBL247 Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 2
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 2
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
ERG1_RAT P52020 CHEMBL4241 Squalene Monooxygenase, Rat 1
FABI_ECOLI P0AEK4 CHEMBL1857 Enoyl-[acyl-carrier-protein] Reductase, Ecoli 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
MDHC_PIG P11708 CHEMBL4048 Malate Dehydrogenase Cytoplasmic, Pig 1
MDHM_PIG P00346 CHEMBL3444 Malate Dehydrogenase Mitochondrial, Pig 1
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 1
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1
Q0PJ46_PLAFA Q0PJ46 CHEMBL6071 Lactate Dehydrogenase, Plafa 1
Q49PX0_9POXV Q49PX0 CHEMBL1075128 N1L, 9poxv 1
Q6VVP7_PLAFA Q6VVP7 CHEMBL6072 Malate Dehydrogenase, Plafa 1

Most Common Rings