UCSF

Matrix Metalloproteinase 14, Human (507 Compounds)

Swissprot:
MMP14_HUMAN
Stitch:
MMP14_HUMAN
UniProt:
P50281
ChEMBL:
CHEMBL3869
Reactome:
REACT_118682
REACT_150401
REACT_118572
PDB:
1BQQ (DOCK)
1BUV (DOCK)
3C7X (DOCK)
3MA2 (DOCK)
MMP14

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 507 9 8 14
Binding ≤ 1μM 341 7 4 11

Reactome Network (3)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 5
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 6
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 274
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 27
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 53
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 193
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 7
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 381
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 121
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 53
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 198
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 300

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 14
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 106
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 5
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 6
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 73
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 274
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 27
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 193
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 381
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 121
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 53
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 198
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 300

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 14
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 1
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 28
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 43
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 5
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 6
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 73
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 274
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 27
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 193
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 381
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 121
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 53
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 198
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 300
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 289 8 4 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 30 1 1 3
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2,665 22 9 44
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2,765 37 17 44
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2,212 22 9 40
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 467 10 4 22
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 980 16 6 25
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2,243 31 11 34

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
MMP14-1-E Matrix Metalloproteinase 14 (cluster #1 Of 3), Eukaryotic 295 3 6 2
MMP14-2-E Matrix Metalloproteinase 14 (cluster #2 Of 3), Eukaryotic 202 5 1 10
MMP14-3-E Matrix Metalloproteinase 14 (cluster #3 Of 3), Eukaryotic 10 1 1 2
Uniprot Swissprot Chembl Description Number Shared
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 381
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 300
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 274
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 198
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 193
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 121
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 104
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 73
MMP11_MOUSE Q02853 CHEMBL3412 Matrix Metalloproteinase 11, Mouse 65
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 53
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 53
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 43
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 28
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 27
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 14
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 9
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 8
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 8
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 7
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 6
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 5
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 5
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 5
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 3
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 3
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 2
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 2
6PGD_HUMAN P52209 CHEMBL3404 6-phosphogluconate Dehydrogenase, Human 1
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADA17_MOUSE Q9Z0F8 CHEMBL4379 ADAM17, Mouse 1
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 1
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 1
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 1
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 1
ERG1_RAT P52020 CHEMBL4241 Squalene Monooxygenase, Rat 1
FCER2_HUMAN P06734 CHEMBL2940 Immunoglobulin Epsilon Fc Receptor, Human 1
G6PD_YEAST P11412 CHEMBL1075249 Glucose-6-phosphate 1-dehydrogenase, Yeast 1
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 1
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 1
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 1
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 1
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 1
Q72547_9HIV1 Q72547 CHEMBL247 Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1

Most Common Rings