ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (2,513)
Reactome (4)
Related By:
Pathway (26)
Organism (2)
Gene (15)
Org. Clust. (3)
ChEMBL (48)
Rings (34)

Matrix Metalloproteinase 13, Human (2,513 Compounds)

Swissprot:: MMP13_HUMAN
Stitch:: MMP13_HUMAN
UniProt:: P45452
ChEMBL:: CHEMBL280
Reactome:: REACT_118682; REACT_150180; REACT_150401; REACT_118572
PDB:: 1EUB (DOCK); 1FLS (DOCK); 1FM1 (DOCK); 1PEX (DOCK); 1UC1 (DOCK); 1XUC (DOCK); 1XUD (DOCK); 1XUR (DOCK); 1YOU (DOCK); 1ZTQ (DOCK); 2D1N (DOCK); 2E2D (DOCK); 2OW9 (DOCK); 2OZR (DOCK); 2PJT (DOCK); 2YIG (DOCK); 3ELM (DOCK); 3I7G (DOCK); 3I7I (DOCK); 3KEC (DOCK); 3KEJ (DOCK); 3KEK (DOCK); 3KRY (DOCK); 3LJZ (DOCK); 3O2X (DOCK); 3ZXH (DOCK); 456C (DOCK); 4A7B (DOCK); 830C (DOCK); MMP13

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	2,513	43	6	37
Binding ≤ 1μM	2,258	24	5	32
Functional ≤ 10μM	1	0	0	0

Reactome ID	Description	Species
REACT_118682	Activation of Matrix Metalloproteinases	Homo sapiens
REACT_150180	Assembly of collagen fibrils and other multimeric structures	Homo sapiens
REACT_150401	Collagen degradation	Homo sapiens
REACT_118572	Degradation of the extracellular matrix	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	4
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	2
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	274
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	5
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	34
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	19
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	1373
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	1
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	1087
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	702
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	291
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	434
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	960

Assembly of collagen fibrils and other multimeric structures

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	702
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	291
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	960

Collagen degradation

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	10
ADA17_HUMAN	P78536	CHEMBL3706	ADAM17, Human	605
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	1
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	4
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	2
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	154
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	274
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	5
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	1373
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	1087
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	702
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	291
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	434
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	960

Degradation of the extracellular matrix

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	10
ATS4_HUMAN	O75173	CHEMBL2318	ADAMTS4, Human	77
ATS5_HUMAN	Q9UNA0	CHEMBL2285	ADAMTS5, Human	14
BMP1_HUMAN	P13497	CHEMBL3898	Bone Morphogenetic Protein 1, Human	1
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	4
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	2
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	154
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	274
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	5
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	1373
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	1087
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	702
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	291
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	434
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	960

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
MMP13_BOVIN	O77656	CHEMBL5327	Matrix Metalloproteinase 13, Bovin	47	1	0	0
MMP13_RAT	P23097	CHEMBL4944	Matrix Metalloproteinase 13, Rat	13	0	0	3

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	82	1	1	1
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	71	1	1	1
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	289	8	4	5
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	507	9	8	14
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	30	1	1	3
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	61	3	1	4
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	29	1	1	1
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	2,665	22	9	44
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	8	0	0	1
MMP26_HUMAN	Q9NRE1	CHEMBL4707	Matrix Metalloproteinase 26, Human	23	1	1	2
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	2,765	37	17	44
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	2,212	22	9	40
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	467	10	4	22
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	980	16	6	25
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	2,243	31	11	34

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
MMP13-1-E	Matrix Metalloproteinase 13 (cluster #1 Of 4), Eukaryotic	1,299	20	3	18
MMP13-2-E	Matrix Metalloproteinase 13 (cluster #2 Of 4), Eukaryotic	238	6	0	6
MMP13-3-E	Matrix Metalloproteinase 13 (cluster #3 Of 4), Eukaryotic	786	6	2	13
MMP13-4-E	Matrix Metalloproteinase 13 (cluster #4 Of 4), Eukaryotic	240	12	2	4

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	1373
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	1087
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	960
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	702
ADA17_HUMAN	P78536	CHEMBL3706	ADAM17, Human	572
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	434
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	291
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	274
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	154
ATS4_HUMAN	O75173	CHEMBL2318	ADAMTS4, Human	77
ADA17_PIG	O77636	CHEMBL3332	ADAM17, Pig	63
CAH2_HUMAN	P00918	CHEMBL205	Carbonic Anhydrase II, Human	50
CAH4_BOVIN	Q95323	CHEMBL281	Carbonic Anhydrase IV, Bovin	50
CAH1_HUMAN	P00915	CHEMBL261	Carbonic Anhydrase I, Human	40
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	34
ATS5_BOVIN	Q9TT92	CHEMBL2673	ADAMTS5, Bovin	29
MMP13_BOVIN	O77656	CHEMBL5327	Matrix Metalloproteinase 13, Bovin	27
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	19
TNFA_HUMAN	P01375	CHEMBL1825	TNF-alpha, Human	19
ATS5_HUMAN	Q9UNA0	CHEMBL2285	ADAMTS5, Human	14
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	10
COLA_CLOPE	P43153	CHEMBL2802	Microbial Collagenase, Clope	8
DEF_ECOLI	P0A6K3	CHEMBL4976	Peptide Deformylase, Ecoli	8
MMP12_MOUSE	P34960	CHEMBL2594	Matrix Metalloproteinase 12, Mouse	8
ADA17_RAT	Q9Z1K9	CHEMBL2523	ADAM17, Rat	7
ACE_HUMAN	P12821	CHEMBL1808	Angiotensin-converting Enzyme, Human	5
ECE1_HUMAN	P42892	CHEMBL4791	Endothelin-converting Enzyme 1, Human	5
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	5
NEP_HUMAN	P08473	CHEMBL1944	Neprilysin, Human	5
NEP_RAT	P07861	CHEMBL3369	Neprilysin, Rat	5
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	4
MMP2_MOUSE	P33434	CHEMBL3095	Matrix Metalloproteinase-2, Mouse	3
MMP9_MOUSE	P41245	CHEMBL2214	Matrix Metalloproteinase 9, Mouse	3
CAH9_HUMAN	Q16790	CHEMBL3594	Carbonic Anhydrase IX, Human	2
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	2
LEF_BACAN	P15917	CHEMBL4372	Anthrax Lethal Factor, Bacan	2
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	2
MMP12_RAT	Q63341	CHEMBL5506	Macrophage Metalloelastase, Rat	2
MMP13_RAT	P23097	CHEMBL4944	Matrix Metalloproteinase 13, Rat	2
Z50264	Z50264	CHEMBL356	Streptococcus Pyogenes	2
ADA12_HUMAN	O43184	CHEMBL5030	ADAM12, Human	1
ADA17_MOUSE	Q9Z0F8	CHEMBL4379	ADAM17, Mouse	1
ADA33_HUMAN	Q9BZ11	CHEMBL6121	Disintegrin And Metalloproteinase Domain-containing Protein 33, Human	1
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	1
BMP1_HUMAN	P13497	CHEMBL3898	Bone Morphogenetic Protein 1, Human	1
FCER2_HUMAN	P06734	CHEMBL2940	Immunoglobulin Epsilon Fc Receptor, Human	1
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	1
MMP26_HUMAN	Q9NRE1	CHEMBL4707	Matrix Metalloproteinase 26, Human	1