UCSF

Matrix Metalloproteinase-1, Human (2,665 Compounds)

Swissprot:
MMP1_HUMAN
Stitch:
MMP1_HUMAN
UniProt:
P03956
ChEMBL:
CHEMBL332
Reactome:
REACT_118682
REACT_12560
REACT_150401
REACT_118572
REACT_15428
PDB:
1AYK (DOCK)
1CGE (DOCK)
1CGF (DOCK)
1CGL (DOCK)
1HFC (DOCK)
1SU3 (DOCK)
2AYK (DOCK)
2CLT (DOCK)
2J0T (DOCK)
2TCL (DOCK)
3AYK (DOCK)
3SHI (DOCK)
4AYK (DOCK)
966C (DOCK)
MMP1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,665 22 9 44
Binding ≤ 1μM 1,855 13 8 35

Reactome Network (5)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_12560 Basigin interactions Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_15428 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 5
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 4
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 1373
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 193
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 19
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 33
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 4
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 999
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1103
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 373
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 402
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1232

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 583
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 64
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 4
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 5
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 4
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 73
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 1373
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 193
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 19
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 999
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1103
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 373
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 402
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1232

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 45
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 23
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 4
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 4
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 5
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 4
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 73
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 1373
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 193
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 19
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 999
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1103
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 373
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 402
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1232

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l

Uniprot Swissprot Chembl Description Number Shared
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 999
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 289 8 4 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 507 9 8 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 30 1 1 3
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2,765 37 17 44
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2,212 22 9 40
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 467 10 4 22
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 980 16 6 25
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2,243 31 11 34

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
MMP1-1-E Matrix Metalloproteinase-1 (cluster #1 Of 2), Eukaryotic 1,868 16 3 28
MMP1-2-E Matrix Metalloproteinase-1 (cluster #2 Of 2), Eukaryotic 820 8 8 19
Uniprot Swissprot Chembl Description Number Shared
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 1373
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1232
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1103
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 999
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 560
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 402
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 373
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 193
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 73
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 64
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 54
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 50
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 45
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 44
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 33
FCER2_HUMAN P06734 CHEMBL2940 Immunoglobulin Epsilon Fc Receptor, Human 31
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 29
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 23
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 23
MMP9_RAT P50282 CHEMBL3870 Matrix Metalloproteinase 9, Rat 23
TIMP3_RAT P48032 CHEMBL3881 Tissue Inhibitor Of Metalloproteinases-3, Rat 23
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 19
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 19
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 18
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 17
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 16
COLA_CLOPE P43153 CHEMBL2802 Microbial Collagenase, Clope 16
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 14
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 14
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 14
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 14
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 14
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 12
ATTY_RAT P04694 CHEMBL5947 Tyrosine Aminotransferase, Rat 10
NEP_RAT P07861 CHEMBL3369 Neprilysin, Rat 9
ADA17_RAT Q9Z1K9 CHEMBL2523 ADAM17, Rat 7
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 7
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 6
Z50264 Z50264 CHEMBL356 Streptococcus Pyogenes 6
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 5
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 4
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 4
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 4
MMP11_MOUSE Q02853 CHEMBL3412 Matrix Metalloproteinase 11, Mouse 4
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 4
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 3
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 3
PRGR_HUMAN P06401 CHEMBL208 Progesterone Receptor, Human 3
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 2
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 2
DEFM_HUMAN Q9HBH1 CHEMBL4647 Peptide Deformylase Mitochondrial, Human 2
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 2
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
DEF1A_ARATH Q9FV53 CHEMBL1075041 Peptide Deformylase 1A, Chloroplastic, Arath 1
DEF_STAAM P68825 CHEMBL2367 Peptide Deformylase, Staam 1
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 1
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 1
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
Q9JN24_ECOLX Q9JN24 CHEMBL1795101 Peptide Deformylase, Ecolx 1

Most Common Rings