UCSF

Neprilysin, Rat (545 Compounds)

Swissprot:
NEP_RAT
Stitch:
NEP_RAT
UniProt:
P07861
ChEMBL:
CHEMBL3369
Reactome:
REACT_198807
PDB:
Mme

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 545 4 7 11
Binding ≤ 1μM 512 3 7 11
Functional ≤ 10μM 10 2 2 3

Reactome Network (1)

Reactome ID Description Species
REACT_198807 Metabolism of Angiotensinogen to Angiotensins Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
ACE2_RAT Q5EGZ1 CHEMBL2311 Angiotensin-converting Enzyme-related Carboxypeptidase, Rat 14
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 912 5 7 19
NEP_MOUSE Q61391 CHEMBL2642 Neprilysin, Mouse 18 8 0 0
NEP_PIG P19621 CHEMBL6107 Neprilysin, Pig 34 2 2 2
NEP_RABIT P08049 CHEMBL3768 Neprilysin, Rabit 78 0 0 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
NEP-1-E Neprilysin (cluster #1 Of 2), Eukaryotic 289 2 0 5
NEP-2-E Neprilysin (cluster #2 Of 2), Eukaryotic 1,310 14 11 20
Uniprot Swissprot Chembl Description Number Shared
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 77
ACE_RABIT P12822 CHEMBL4074 Angiotensin-converting Enzyme, Rabit 44
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 39
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 36
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 15
ACE2_RAT Q5EGZ1 CHEMBL2311 Angiotensin-converting Enzyme-related Carboxypeptidase, Rat 14
AMPN_PIG P15145 CHEMBL2590 Aminopeptidase N, Pig 12
DPP3_RAT O55096 CHEMBL2233 Dipeptidyl Peptidase III, Rat 12
DPP4_RAT P14740 CHEMBL4653 Dipeptidyl Peptidase IV, Rat 12
ECE1_BOVIN P42891 CHEMBL2340 Endothelin-converting Enzyme 1, Bovin 12
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 9
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 9
ACE_RAT P47820 CHEMBL2625 Angiotensin-converting Enzyme, Rat 5
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 5
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 5
Z50264 Z50264 CHEMBL356 Streptococcus Pyogenes 5
ACE_MOUSE P09470 CHEMBL2994 Angiotensin-converting Enzyme, Mouse 4
LCAP_HUMAN Q9UIQ6 CHEMBL2693 Cystinyl Aminopeptidase, Human 4
NEP_RABIT P08049 CHEMBL3768 Neprilysin, Rabit 4
THER_BACTH P00800 CHEMBL3392 Thermolysin, Bacth 4
AMPE_PIG Q95334 CHEMBL4868 Aminopeptidase A, Pig 3
DPP2_RAT Q9EPB1 CHEMBL4352 Dipeptidyl Peptidase II, Rat 3
DPP6_RAT P46101 CHEMBL4353 Dipeptidyl Peptidase VI, Rat 3
NEP_PIG P19621 CHEMBL6107 Neprilysin, Pig 2
AMPB_HUMAN Q9H4A4 CHEMBL2432 Aminopeptidase B, Human 1
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 1
AMPN_HUMAN P15144 CHEMBL1907 Aminopeptidase N, Human 1
ANF_HUMAN P01160 CHEMBL1293193 Atrial Natriuretic Factor, Human 1
ECE1_RAT P42893 CHEMBL2676 Endothelin-converting Enzyme 1, Rat 1
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 1

Most Common Rings