UCSF

Receptor Protein-tyrosine Kinase ErbB-2, Human (936 Compounds)

Swissprot:
ERBB2_HUMAN
Stitch:
ERBB2_HUMAN
UniProt:
P04626
ChEMBL:
CHEMBL1824
Reactome:
REACT_147727
REACT_115662
REACT_115854
REACT_115896
REACT_116008
REACT_75829
REACT_115720
REACT_19277
REACT_115993
REACT_115755
PDB:
1MFG (DOCK)
1MFL (DOCK)
1MW4 (DOCK)
1N8Z (DOCK)
1OVC (DOCK)
1QR1 (DOCK)
1S78 (DOCK)
2A91 (DOCK)
2JWA (DOCK)
2KS1 (DOCK)
2L4K (DOCK)
3BE1 (DOCK)
3H3B (DOCK)
3MZW (DOCK)
3N85 (DOCK)
3PP0 (DOCK)
3RCD (DOCK)
ERBB2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 936 42 10 12
Binding ≤ 1μM 748 20 9 11
Functional ≤ 10μM 212 21 6 6

Reactome Network (10)

Reactome ID Description Species
REACT_147727 Constitutive PI3K/AKT Signaling in Cancer Homo sapiens
REACT_115662 Downregulation of ERBB2:ERBB3 signaling Homo sapiens
REACT_115854 GRB2 events in ERBB2 signaling Homo sapiens
REACT_115896 GRB7 events in ERBB2 signaling Homo sapiens
REACT_116008 PI3K events in ERBB2 signaling Homo sapiens
REACT_75829 PIP3 activates AKT signaling Homo sapiens
REACT_115720 PLCG1 events in ERBB2 signaling Homo sapiens
REACT_19277 Sema4D induced cell migration and growth-cone collapse Homo sapiens
REACT_115993 SHC1 events in ERBB2 signaling Homo sapiens
REACT_115755 Signaling by ERBB2 Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 848
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 3
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 6
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 3
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 2
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 10
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 30
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 5
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 35

Downregulation of ERBB2:ERBB3 signaling

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1

GRB2 events in ERBB2 signaling

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 848

PI3K events in ERBB2 signaling

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 848

PIP3 activates AKT signaling

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 848
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 3
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 6
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 10
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 30
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 5
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 35

PLCG1 events in ERBB2 signaling

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 848

Sema4D induced cell migration and growth-cone collapse

Uniprot Swissprot Chembl Description Number Shared
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 1
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 2

SHC1 events in ERBB2 signaling

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 848

Signaling by ERBB2

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 848
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 6
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 4
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 18
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 8
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ERBB2_RAT P06494 CHEMBL3848 Receptor Protein-tyrosine Kinase ErbB-2, Rat 13 1 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ERBB4_HUMAN Q15303 CHEMBL3009 Receptor Protein-tyrosine Kinase ErbB-4, Human 33 6 2 4

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
ERBB2-1-E Receptor Protein-tyrosine Kinase ErbB-2 (cluster #1 Of 3), Eukaryotic 35 4 1 0
ERBB2-2-E Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic 896 27 9 12
ERBB2-3-E Receptor Protein-tyrosine Kinase ErbB-2 (cluster #3 Of 3), Eukaryotic 23 12 0 0
Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 833
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 89
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 84
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 79
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 68
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 63
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 48
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 47
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 35
ERBB4_HUMAN Q15303 CHEMBL3009 Receptor Protein-tyrosine Kinase ErbB-4, Human 31
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 29
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 26
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 24
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 23
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 21
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 21
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 20
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 18
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 17
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 15
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 15
Z80046 Z80046 CHEMBL614529 BT-474 (Breast Ductal Carcinoma Cells) 14
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 13
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 12
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 12
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 11
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 11
Z80961 Z80961 CHEMBL614828 HN5 (Squamous Cell Carcinoma) 11
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 10
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 10
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 9
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 9
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 9
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 9
Z80904 Z80904 CHEMBL614786 HB4a 9
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 8
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 8
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 8
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 8
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 8
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 7
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 7
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 7
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 7
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 7
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 7
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 6
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 6
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 6
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 6
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 6
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 6
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 6
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 6
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 6
Z80300 Z80300 CHEMBL612281 N87 (Gastric Carcinoma Cells) 6
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 5
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 5
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 5
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 5
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 5
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 5
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 5
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 5
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 5
M4K5_HUMAN Q9Y4K4 CHEMBL4852 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 5
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 5
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 5
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 5
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 5
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 5
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 5
SIK2_HUMAN Q9H0K1 CHEMBL5699 Serine/threonine-protein Kinase SIK2, Human 5
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein Kinase Receptor Tie-1, Human 5
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 5
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 5
UFO_HUMAN P30530 CHEMBL4895 Tyrosine-protein Kinase Receptor UFO, Human 5
Z81115 Z81115 CHEMBL398 KB (Squamous Cell Carcinoma) 5
ADCK3_HUMAN Q8NI60 CHEMBL5550 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 4
ADCK4_HUMAN Q96D53 CHEMBL5753 Uncharacterized AarF Domain-containing Protein Kinase 4, Human 4
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 4
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 4
BMX_HUMAN P51813 CHEMBL3834 Tyrosine-protein Kinase BMX, Human 4
BTK_HUMAN Q06187 CHEMBL5251 Tyrosine-protein Kinase BTK, Human 4
CSK_HUMAN P41240 CHEMBL2634 Tyrosine-protein Kinase CSK, Human 4
DMPK_HUMAN Q09013 CHEMBL5320 Myotonin-protein Kinase, Human 4
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 4
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 4
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 4
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 4
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 4
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 4
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 4
M3K4_HUMAN Q9Y6R4 CHEMBL4853 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 4
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 4
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 4
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 4
MYLK2_HUMAN Q9H1R3 CHEMBL2777 Myosin Light Chain Kinase 2, Human 4
PHKG1_HUMAN Q16816 CHEMBL4004 Phosphorylase Kinase Gamma Subunit 1, Human 4
PHKG2_HUMAN P15735 CHEMBL2349 Phosphorylase Kinase Gamma Subunit 2, Human 4
SRMS_HUMAN Q9H3Y6 CHEMBL5703 Tyrosine-protein Kinase Srms, Human 4
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 4
TYRO3_HUMAN Q06418 CHEMBL5314 Tyrosine-protein Kinase Receptor TYRO3, Human 4
Z100492 Z100492 CHEMBL613878 MCF10 (Normal Breast Epithelial Cells) 4
ACVR1_HUMAN Q04771 CHEMBL5903 Activin Receptor Type-1, Human 3
BMP2K_HUMAN Q9NSY1 CHEMBL4522 BMP-2-inducible Protein Kinase, Human 3
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 3
E2AK4_HUMAN Q9P2K8 CHEMBL5358 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 3
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 3
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 3
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 3
ITK_HUMAN Q08881 CHEMBL2959 Tyrosine-protein Kinase ITK/TSK, Human 3
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 3
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 3
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 3
LTK_HUMAN P29376 CHEMBL5627 Leukocyte Tyrosine Kinase Receptor, Human 3
M4K3_HUMAN Q8IVH8 CHEMBL5432 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 3
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 3
MK06_HUMAN Q16659 CHEMBL5121 Mitogen-activated Protein Kinase 6, Human 3
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 3
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 3
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 3
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 3
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 3
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 3
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 3
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 3
TESK1_HUMAN Q15569 CHEMBL5604 Dual Specificity Testis-specific Protein Kinase 1, Human 3
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 3
ULK3_MOUSE Q3U3Q1 CHEMBL3832 ULK3 Kinase, Mouse 3
Z103205 Z103205 CHEMBL1075390 A431 3
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 3
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 3
AAK1_HUMAN Q2M2I8 CHEMBL3830 Adaptor-associated Kinase, Human 2
ACK1_HUMAN Q07912 CHEMBL4599 Tyrosine Kinase Non-receptor Protein 2, Human 2
ACVL1_HUMAN P37023 CHEMBL5311 Serine/threonine-protein Kinase Receptor R3, Human 2
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 2
BLK_MOUSE P16277 CHEMBL3343 Tyrosine-protein Kinase BLK, Mouse 2
CDK16_HUMAN Q00536 CHEMBL4597 Serine/threonine-protein Kinase PCTAIRE-1, Human 2
DAPK3_HUMAN O43293 CHEMBL2468 Death-associated Protein Kinase 3, Human 2
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 2
E2AK2_HUMAN P19525 CHEMBL5785 Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human 2
F16P1_HUMAN P09467 CHEMBL3975 Fructose-1,6-bisphosphatase, Human 2
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 2
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 2
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 2
HS90A_MOUSE P07901 CHEMBL4197 Heat Shock Protein HSP 90-alpha, Mouse 2
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 2
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 2
IRAK3_HUMAN Q9Y616 CHEMBL5081 Interleukin-1 Receptor-associated Kinase 3, Human 2
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 2
KS6A1_HUMAN Q15418 CHEMBL2553 Ribosomal Protein S6 Kinase Alpha 1, Human 2
LCK_MOUSE P06240 CHEMBL2480 Tyrosine-protein Kinase LCK, Mouse 2
M3K11_HUMAN Q16584 CHEMBL2708 Mitogen-activated Protein Kinase Kinase Kinase 11, Human 2
M4K1_HUMAN Q92918 CHEMBL5749 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 2
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 2
MK04_HUMAN P31152 CHEMBL5759 Mitogen-activated Protein Kinase 4, Human 2
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 2
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 2
NEK2_HUMAN P51955 CHEMBL3835 Serine/threonine-protein Kinase NEK2, Human 2
PAK1_HUMAN Q13153 CHEMBL4600 Serine/threonine-protein Kinase PAK 1, Human 2
PLK4_HUMAN O00444 CHEMBL3788 Serine/threonine-protein Kinase PLK4, Human 2
PMYT1_HUMAN Q99640 CHEMBL3984 Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human 2
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 2
SGK1_HUMAN O00141 CHEMBL2343 Serine/threonine-protein Kinase Sgk1, Human 2
SIK1_HUMAN P57059 CHEMBL6082 Serine/threonine-protein Kinase SIK1, Human 2
ST17B_HUMAN O94768 CHEMBL3980 Serine/threonine-protein Kinase 17B, Human 2
STK33_HUMAN Q9BYT3 CHEMBL6005 Serine/threonine-protein Kinase 33, Human 2
STK3_HUMAN Q13188 CHEMBL4708 Serine/threonine-protein Kinase MST2, Human 2
TEC_HUMAN P42680 CHEMBL4246 Tyrosine-protein Kinase TEC, Human 2
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 2
VGFR1_MOUSE P35969 CHEMBL3516 Vascular Endothelial Growth Factor Receptor 1, Mouse 2
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 2
Z80262 Z80262 CHEMBL614348 NCI-H1975 (Bronchoalveolar Carcinoma Cells) 2
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 2
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 2
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 2
AAPK1_HUMAN Q13131 CHEMBL4045 AMP-activated Protein Kinase, Alpha-1 Subunit, Human 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
ACV1B_HUMAN P36896 CHEMBL5310 Activin Receptor Type-1B, Human 1
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1
ANKK1_HUMAN Q8NFD2 CHEMBL5547 Ankyrin Repeat And Protein Kinase Domain-containing Protein 1, Human 1
AVR2A_HUMAN P27037 CHEMBL5616 Activin Receptor Type-2A, Human 1
AVR2B_HUMAN Q13705 CHEMBL5466 Activin Receptor Type-2B, Human 1
CD11A_HUMAN Q9UQ88 CHEMBL5416 PITSLRE Serine/threonine-protein Kinase CDC2L2, Human 1
CD11B_HUMAN P21127 CHEMBL5808 PITSLRE Serine/threonine-protein Kinase CDC2L1, Human 1
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CDK8_HUMAN P49336 CHEMBL5719 Cell Division Protein Kinase 8, Human 1
CHK1_HUMAN O14757 CHEMBL4630 Serine/threonine-protein Kinase Chk1, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 1
CLK3_HUMAN P49761 CHEMBL4226 Dual Specificity Protein Kinase CLK3, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
DCLK3_HUMAN Q9C098 CHEMBL6123 Serine/threonine-protein Kinase DCLK3, Human 1
DYR1B_HUMAN Q9Y463 CHEMBL5543 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 1
ENPL_CANFA P41148 CHEMBL4748 Heat Shock Protein 90 Beta, Canine 1
EPHB3_HUMAN P54753 CHEMBL4901 Ephrin Type-B Receptor 3, Human 1
ERBB2_RAT P06494 CHEMBL3848 Receptor Protein-tyrosine Kinase ErbB-2, Rat 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
F16P1_PIG P00636 CHEMBL2263 Fructose-1,6-bisphosphatase, Pig 1
FER_HUMAN P16591 CHEMBL3982 Tyrosine-protein Kinase FER, Human 1
FES_HUMAN P07332 CHEMBL5455 Tyrosine-protein Kinase FES, Human 1
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 1
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 1
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 1
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 1
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 1
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 1
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 1
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 1
KC1AL_HUMAN Q8N752 CHEMBL5520 Casein Kinase I Isoform Alpha-like, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KCC1D_HUMAN Q8IU85 CHEMBL5073 CaM Kinase I Delta, Human 1
KKCC1_HUMAN Q8N5S9 CHEMBL5256 CaM-kinase Kinase Alpha, Human 1
KKCC2_HUMAN Q96RR4 CHEMBL5284 CaM-kinase Kinase Beta, Human 1
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 1
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 1
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 1
KPCD3_HUMAN O94806 CHEMBL2595 Protein Kinase C Nu, Human 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1
KPCG_HUMAN P05129 CHEMBL2938 Protein Kinase C Gamma, Human 1
KPCI_HUMAN P41743 CHEMBL2598 Protein Kinase C Iota, Human 1
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 1
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 1
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 1
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
KS6A4_HUMAN O75676 CHEMBL3125 Ribosomal Protein S6 Kinase Alpha 4, Human 1
KS6A6_HUMAN Q9UK32 CHEMBL4924 Ribosomal Protein S6 Kinase Alpha 6, Human 1
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 1
MAPK2_HUMAN P49137 CHEMBL2208 MAP Kinase-activated Protein Kinase 2, Human 1
MAPK5_HUMAN Q8IW41 CHEMBL3094 MAP Kinase-activated Protein Kinase 5, Human 1
MARK1_HUMAN Q9P0L2 CHEMBL5940 Serine/threonine-protein Kinase MARK1, Human 1
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
MUSK_HUMAN O15146 CHEMBL5684 Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human 1
MYLK3_HUMAN Q32MK0 CHEMBL4627 Myosin Light Chain Kinase, Human 1
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 1
NEK1_HUMAN Q96PY6 CHEMBL5855 Serine/threonine-protein Kinase Nek1, Human 1
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
NUAK2_HUMAN Q9H093 CHEMBL5698 NUAK Family SNF1-like Kinase 2, Human 1
PDK1_HUMAN Q15118 CHEMBL4766 Pyruvate Dehydrogenase Kinase Isoform 1, Human 1
PGFRA_RAT P20786 CHEMBL2513 Platelet-derived Growth Factor Receptor Alpha, Rat 1
PGFRB_RAT Q05030 CHEMBL4125 Platelet-derived Growth Factor Receptor Beta, Rat 1
PI42B_HUMAN P78356 CHEMBL5667 Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 1
ST32B_HUMAN Q9NY57 CHEMBL5912 Serine/threonine-protein Kinase 32B, Human 1
ST38L_HUMAN Q9Y2H1 CHEMBL4851 Serine/threonine-protein Kinase 38-like, Human 1
STK24_HUMAN Q9Y6E0 CHEMBL5082 Serine/threonine-protein Kinase 24, Human 1
STK25_HUMAN O00506 CHEMBL5552 Serine/threonine-protein Kinase 25, Human 1
STK3_MOUSE Q9JI10 CHEMBL4310 Serine/threonine-protein Kinase MST2, Mouse 1
STK4_HUMAN Q13043 CHEMBL4598 Serine/threonine-protein Kinase MST1, Human 1
TNK1_HUMAN Q13470 CHEMBL5334 Non-receptor Tyrosine-protein Kinase TNK1, Human 1
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 1
Z100731 Z100731 CHEMBL613842 Bcap37 (Breast Carcinoma Cells) 1
Z103348 Z103348 CHEMBL1075533 NCI-H2122 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1
Z80036 Z80036 CHEMBL614524 BaF3 (IL-3-dependent Pro-B-cells) 1
Z80037 Z80037 CHEMBL614065 Balb/MK 1
Z80058 Z80058 CHEMBL614534 Calu-3 1
Z80188 Z80188 CHEMBL614590 KB 3-1 (Cervical Epithelial Carcinoma Cells) 1
Z80322 Z80322 CHEMBL614135 NCI-H358 (Lung Carcinama Cells) 1
Z80359 Z80359 CHEMBL614064 P19 1
Z80416 Z80416 CHEMBL614630 Rat1 (Fibroblast Cells) 1
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 1
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 1
Z81051 Z81051 CHEMBL613974 Human Tumor Cell Lines 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1
Z81125 Z81125 CHEMBL613997 KU812 Cell Line 1
Z81186 Z81186 CHEMBL614097 LS174T (Colon Adencocarcinoma Cells) 1
Z81328 Z81328 CHEMBL614302 Src-transformed (Fibroblast Cells) 1
ZAP70_HUMAN P43403 CHEMBL2803 Tyrosine-protein Kinase ZAP-70, Human 1

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