UCSF

ADAM10, Human (168 Compounds)

Swissprot:
ADA10_HUMAN
Stitch:
ADA10_HUMAN
UniProt:
O14672
ChEMBL:
CHEMBL5028
Reactome:
REACT_118614
REACT_150401
REACT_160089
REACT_160254
REACT_160243
REACT_160106
REACT_118572
REACT_228189
REACT_160205
REACT_9417
REACT_118862
REACT_118636
PDB:
1M1I (DOCK)
ADAM10

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 168 1 1 2
Binding ≤ 1μM 161 1 1 2

Reactome Network (12)

Reactome ID Description Species
REACT_118614 Activated NOTCH1 Transmits Signal to the Nucleus Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_160089 Constitutive Signaling by NOTCH1 HD Domain Mutants Homo sapiens
REACT_160254 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Homo sapiens
REACT_160243 Constitutive Signaling by NOTCH1 PEST Domain Mutants Homo sapiens
REACT_160106 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_228189 EPH-ephrin mediated repulsion of cells Homo sapiens
REACT_160205 NOTCH2 Activation and Transmission of Signal to the Nucleus Homo sapiens
REACT_9417 Signaling by EGFR Homo sapiens
REACT_118862 Signaling by NOTCH3 Homo sapiens
REACT_118636 Signaling by NOTCH4 Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 21

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 21
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 4
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 10
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 21
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 135
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 34
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 4
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 3
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 57

Constitutive Signaling by NOTCH1 HD Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 21

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 21

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 21

Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

Uniprot Swissprot Chembl Description Number Shared
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 21

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 4
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 10
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 21
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 135
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 34
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 4
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 3
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 57

EPH-ephrin mediated repulsion of cells

Uniprot Swissprot Chembl Description Number Shared
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 135
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 57

Signaling by EGFR

Uniprot Swissprot Chembl Description Number Shared
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 21
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 8 8 1 1
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 1,592 7 5 20
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 1,217 94 55 50
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 1,203 86 55 50
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 1,085 77 49 46
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 690 104 52 54
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 422 76 40 40
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 620 92 51 50
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 3 0 0 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1 0 0 0
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 66 1 1 1
ADA_HUMAN P00813 CHEMBL1910 Adenosine Deaminase, Human 57 6 3 12

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 135
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 68
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 57
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 34
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 21
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 21
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 14
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 10
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 4
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 4
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 3
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 2
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 2
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 1
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 1
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 1
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 1
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 1
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 1