UCSF

Matrix Metalloproteinase 9, Human (2,243 Compounds)

Swissprot:
MMP9_HUMAN
Stitch:
MMP9_HUMAN
UniProt:
P14780
ChEMBL:
CHEMBL321
Reactome:
REACT_118682
REACT_150180
REACT_150401
REACT_118572
REACT_228189
REACT_111040
PDB:
1GKC (DOCK)
1GKD (DOCK)
1ITV (DOCK)
1L6J (DOCK)
1LKG (DOCK)
2OVX (DOCK)
2OVZ (DOCK)
2OW0 (DOCK)
2OW1 (DOCK)
2OW2 (DOCK)
MMP9

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,243 31 11 34
Binding ≤ 1μM 1,947 22 8 29

Reactome Network (6)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150180 Assembly of collagen fibrils and other multimeric structures Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_228189 EPH-ephrin mediated repulsion of cells Homo sapiens
REACT_111040 Signaling by SCF-KIT Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 76
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 960
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 300
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 27
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 55
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 1232
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1387
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 834
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 194
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 610

Assembly of collagen fibrils and other multimeric structures

Uniprot Swissprot Chembl Description Number Shared
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 960
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 834
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 194

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 57
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 457
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 63
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 76
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 83
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 960
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 300
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 27
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 1232
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1387
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 834
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 194
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 610

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 57
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 29
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 26
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 76
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 83
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 960
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 300
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 27
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 1232
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1387
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 834
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 194
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 610

EPH-ephrin mediated repulsion of cells

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 57
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1387
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 3 0 0 1
MMP9_RAT P50282 CHEMBL3870 Matrix Metalloproteinase 9, Rat 35 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 289 8 4 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 507 9 8 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 30 1 1 3
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2,665 22 9 44
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2,765 37 17 44
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2,212 22 9 40
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 467 10 4 22
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 980 16 6 25

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
MMP9-1-E Matrix Metalloproteinase 9 (cluster #1 Of 3), Eukaryotic 1,838 26 6 24
MMP9-2-E Matrix Metalloproteinase 9 (cluster #2 Of 3), Eukaryotic 466 8 7 12
MMP9-3-E Matrix Metalloproteinase 9 (cluster #3 Of 3), Eukaryotic 4 0 0 0
Uniprot Swissprot Chembl Description Number Shared
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1387
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 1232
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 960
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 834
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 610
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 434
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 300
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 194
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 83
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 76
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 66
MMP11_MOUSE Q02853 CHEMBL3412 Matrix Metalloproteinase 11, Mouse 65
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 63
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 57
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 55
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 53
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 52
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 42
COLA_CLOPE P43153 CHEMBL2802 Microbial Collagenase, Clope 40
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 29
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 27
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 26
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 21
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 16
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 11
FCER2_HUMAN P06734 CHEMBL2940 Immunoglobulin Epsilon Fc Receptor, Human 9
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 8
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 8
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8
ATS4_BOVIN Q9TT93 CHEMBL3874 ADAMTS4, Bovin 7
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 4
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 3
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 3
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 3
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 2
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 2
A4_HUMAN P05067 CHEMBL2487 Beta Amyloid A4 Protein, Human 1
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
DEF1A_ARATH Q9FV53 CHEMBL1075041 Peptide Deformylase 1A, Chloroplastic, Arath 1
DEFM_HUMAN Q9HBH1 CHEMBL4647 Peptide Deformylase Mitochondrial, Human 1
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 1
DEF_STAAM P68825 CHEMBL2367 Peptide Deformylase, Staam 1
DHB3_RAT O54939 CHEMBL1075158 Testosterone 17-beta-dehydrogenase 3, Rat 1
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP8_RAT O88766 CHEMBL2312 Matrix Metalloproteinase 8, Rat 1
MMP9_RAT P50282 CHEMBL3870 Matrix Metalloproteinase 9, Rat 1
MTSI_SPISQ P15840 CHEMBL4373 CpG DNA Methylase, Spisq 1
NOS2_HUMAN P35228 CHEMBL4481 Nitric Oxide Synthase, Inducible, Human 1
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 1
Q8HY88_BOVIN Q8HY88 CHEMBL1075183 Potassium Channel Subfamily K Member 2, Bovin 1
Q9JN24_ECOLX Q9JN24 CHEMBL1795101 Peptide Deformylase, Ecolx 1
TIMP3_RAT P48032 CHEMBL3881 Tissue Inhibitor Of Metalloproteinases-3, Rat 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1

Most Common Rings