UCSF

Histone Deacetylase 1, Human (1,826 Compounds)

Swissprot:
HDAC1_HUMAN
Stitch:
HDAC1_HUMAN
UniProt:
Q13547
ChEMBL:
CHEMBL325
Reactome:
REACT_160254
REACT_160243
REACT_200731
REACT_121111
REACT_24970
REACT_200753
REACT_111214
REACT_228222
REACT_200856
REACT_118780
REACT_13695
REACT_228106
REACT_953
REACT_120734
PDB:
1TYI (DOCK)
HDAC1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,826 45 16 13
Binding ≤ 1μM 1,475 34 13 12
Functional ≤ 10μM 122 5 2 5

Reactome Network (14)

Reactome ID Description Species
REACT_160254 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Homo sapiens
REACT_160243 Constitutive Signaling by NOTCH1 PEST Domain Mutants Homo sapiens
REACT_200731 deactivation of the beta-catenin transactivating complex Homo sapiens
REACT_121111 Downregulation of SMAD2/3:SMAD4 transcriptional activity Homo sapiens
REACT_24970 Factors involved in megakaryocyte development and platelet production Homo sapiens
REACT_200753 formation of the beta-catenin:TCF transactivating complex Homo sapiens
REACT_111214 G0 and Early G1 Homo sapiens
REACT_228222 HDACs deacetylate histones Homo sapiens
REACT_200856 NoRC negatively regulates rRNA expression Homo sapiens
REACT_118780 NOTCH1 Intracellular Domain Regulates Transcription Homo sapiens
REACT_13695 p75NTR negatively regulates cell cycle via SC1 Homo sapiens
REACT_228106 repression of WNT target genes Homo sapiens
REACT_953 RNA Polymerase I Transcription Initiation Homo sapiens
REACT_120734 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 473
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 419
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 629
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 560
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 461
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 758
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 451
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 605
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 456
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 473
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 419
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 629
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 560
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 461
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 758
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 451
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 605
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 456
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9

Downregulation of SMAD2/3:SMAD4 transcriptional activity

Uniprot Swissprot Chembl Description Number Shared
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9

Factors involved in megakaryocyte development and platelet production

Uniprot Swissprot Chembl Description Number Shared
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 14
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 4
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669

G0 and Early G1

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 4

HDACs deacetylate histones

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 473
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 629
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 605
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9

NoRC negatively regulates rRNA expression

Uniprot Swissprot Chembl Description Number Shared
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669

NOTCH1 Intracellular Domain Regulates Transcription

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 473
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 419
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 629
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 560
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 461
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 758
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 451
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 605
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 456
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9

p75NTR negatively regulates cell cycle via SC1

Uniprot Swissprot Chembl Description Number Shared
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 629

RNA Polymerase I Transcription Initiation

Uniprot Swissprot Chembl Description Number Shared
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDAC1_CHICK P56517 CHEMBL4582 Histone Deacetylase 1, Chick 21 1 1 0
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 26 3 1 2
HDAC1_RAT Q4QQW4 CHEMBL2915 Histone Deacetylase 1, Rat 76 8 1 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 708 36 14 13
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 619 33 15 14
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 585 27 12 11
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 475 26 10 11
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 845 33 9 12
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 465 25 10 11
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 715 26 10 11
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 462 24 9 11

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
HDAC1-1-E Histone Deacetylase 1 (cluster #1 Of 4), Eukaryotic 1,131 29 13 8
HDAC1-2-E Histone Deacetylase 1 (cluster #2 Of 4), Eukaryotic 667 10 2 5
HDAC1-3-E Histone Deacetylase 1 (cluster #3 Of 4), Eukaryotic 12 6 1 1
HDAC1-4-E Histone Deacetylase 1 (cluster #4 Of 4), Eukaryotic 98 3 0 0
Uniprot Swissprot Chembl Description Number Shared
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 758
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 669
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 629
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 605
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 556
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 473
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 461
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 456
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 451
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 419
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 60
Q94F81_MAIZE Q94F81 CHEMBL4919 Histone Deacetylase HD2, Maize 52
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 51
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 47
HDAC1_RAT Q4QQW4 CHEMBL2915 Histone Deacetylase 1, Rat 43
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 39
B1WBY8_RAT B1WBY8 CHEMBL4705 Histone Deacetylase 2, Rat 35
HDAC3_RAT Q6P6W3 CHEMBL2628 Histone Deacetylase 3, Rat 35
HDAC4_RAT Q99P99 CHEMBL2874 Histone Deacetylase 4, Rat 35
HDAC7_RAT Q99P96 CHEMBL2914 Histone Deacetylase 7, Rat 35
Q5RJZ2_RAT Q5RJZ2 CHEMBL4025 Histone Deacetylase 5, Rat 35
Q99P97_RAT Q99P97 CHEMBL3101 Histone Deacetylase 6, Rat 35
HDAC6_MOUSE Q9Z2V5 CHEMBL2878 Histone Deacetylase 6, Mouse 30
Q7YY76_CRYPV Q7YY76 CHEMBL3626 Histone Deacetylase, Crypv 27
Q7YY07_CRYPV Q7YY07 CHEMBL4740 Histone Deacetylase, Crypv 25
Q9ZTP8_MAIZE Q9ZTP8 CHEMBL3541 Histone Deacetylase HD1B, Maize 17
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 15
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 14
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 13
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9
HDAC1_CHICK P56517 CHEMBL4582 Histone Deacetylase 1, Chick 8
HDAC2_CHICK P56519 CHEMBL4583 Histone Deacetylase 2, Chick 8
HDAC3_CHICK P56520 CHEMBL4584 Histone Deacetylase 3, Chick 8
HDAC4_CHICK P83038 CHEMBL5599 Histone Deacetylase 4, Chick 8
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 7
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 6
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 5
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 5
Q9XYC7_PLAFA Q9XYC7 CHEMBL5541 Histone Deacetylase, Plafa 5
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 5
Z80532 Z80532 CHEMBL614774 T-24 (Bladder Carcinoma Cells) 5
Z80877 Z80877 CHEMBL612255 NCI-H1299 (Non-small Cell Lung Carcinoma) 5
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 4
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 4
Z80525 Z80525 CHEMBL614055 SW48 4
Z81199 Z81199 CHEMBL612440 NCI-H446 (Small Cell Lung Carcinoma Cells) 4
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 4
HDAH_ALCSD Q70I53 CHEMBL6017 Histone Deacetylase-like Amidohydrolase, Alcsd 3
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 3
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 3
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 3
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 3
HDA11_MOUSE Q91WA3 CHEMBL5143 Histone Deacetylase 11, Mouse 2
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 2
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2
HDAC5_MOUSE Q9Z2V6 CHEMBL2768 Histone Deacetylase 5, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 2
HDAC9_MOUSE Q99N13 CHEMBL5204 Histone Deacetylase 9, Mouse 2
Q7K6A1_PLAF7 Q7K6A1 CHEMBL1293190 Histone Deacetylase, Plaf7 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z80269 Z80269 CHEMBL614354 MKN-45 (Gastric Adenocarcinoma Cells) 2
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 2
Z80513 Z80513 CHEMBL614939 SQ20B 2
Z80857 Z80857 CHEMBL614499 Friend Leukemia Cell Line 2
Z80957 Z80957 CHEMBL614734 HMEC (Microvascular Endothelial Cells) 2
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 2
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 2
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 2
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
GALE_HUMAN Q14376 CHEMBL5843 UDP-glucose 4-epimerase, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
MAPK3_HUMAN Q16644 CHEMBL4670 MAP Kinase-activated Protein Kinase 3, Human 1
O53430_MYCTU O53430 CHEMBL3703 Mycothiol S-conjugate Amidase, Myctu 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1
SF3B3_HUMAN Q15393 CHEMBL1250378 Splicing Factor 3B Subunit 3, Human 1
Z102015 Z102015 CHEMBL613013 Plasmodium Vivax 1
Z103205 Z103205 CHEMBL1075390 A431 1
Z103348 Z103348 CHEMBL1075533 NCI-H2122 1
Z103359 Z103359 CHEMBL1075544 NCI-H661 1
Z50136 Z50136 CHEMBL612608 Plasmodium Falciparum (isolate FcB1 / Columbia) 1
Z80054 Z80054 CHEMBL614058 Caco-2 (Colon Adenocarcinoma Cells) 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80123 Z80123 CHEMBL614287 DO4 (Melanoma Cells) 1
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 1
Z80164 Z80164 CHEMBL614580 HT-1080 (Fibrosarcoma Cells) 1
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 1
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 1
Z80244 Z80244 CHEMBL614335 MDA-MB-468 (Breast Adenocarcinoma) 1
Z80277 Z80277 CHEMBL614170 MM96L (Melanoma Cells) 1
Z80322 Z80322 CHEMBL614135 NCI-H358 (Lung Carcinama Cells) 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80485 Z80485 CHEMBL614919 SK-MEL-28 (Melanoma Cells) 1
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 1
Z80514 Z80514 CHEMBL614166 St-4 (Stomach Carcinoma Cells) 1
Z80725 Z80725 CHEMBL613540 C180-13S (Ovarian Carcinoma Cells) 1
Z80838 Z80838 CHEMBL614489 EOL1 (Eosinophilic Cells) 1
Z80851 Z80851 CHEMBL614496 Fibroblast MRHFcell Line 1
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 1
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 1
Z80896 Z80896 CHEMBL614805 NCI-H69 (Small Cell Lung Carcinoma Cells) 1
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 1
Z81070 Z81070 CHEMBL613987 JAM Cell Line 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1
Z81184 Z81184 CHEMBL614096 LOX IMVI (Melanoma Cells) 1
Z81186 Z81186 CHEMBL614097 LS174T (Colon Adencocarcinoma Cells) 1
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 1
Z81280 Z81280 CHEMBL614740 NCI-H226 (Non-small Cell Lung Carcinoma Cells) 1
Z81281 Z81281 CHEMBL614997 NCI-H23 (Non-small Cell Lung Carcinoma Cells) 1
Z81283 Z81283 CHEMBL614387 NCI-H522 (Non-small Cell Lung Carcinoma Cells) 1
Z81335 Z81335 CHEMBL612263 HCT-15 (Colon Adenocarcinoma Cells) 1

Most Common Rings