UCSF
Image of Cyclobutane

Identity 99% 90% 80% 70% Substructure

Cyclobutane

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Ring Information

Rings Ring Systems Atoms Carbons Nitrogens Oxygens Sulfurs
1 1 4 4 0 0 0

Subset Information

Substances Natural Purchasable Annotated BB In Man Last Updated
View 21 30,933 65 3,581 2 2012-03-06

Most Common Targets

Name (Uniprot) Swissprot ChEMBL Description Size Browse Download (Annotations)
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 7 Annotations Catalogs SMILES SDF Mol2 Flexibase
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 7 Annotations Catalogs SMILES SDF Mol2 Flexibase
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR1_RAT P20272 CHEMBL3571 Cannabinoid CB1 Receptor, Rat 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR1_RAT P20272 CHEMBL3571 Cannabinoid CB1 Receptor, Rat 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR2_MOUSE P47936 CHEMBL5373 Cannabinoid CB2 Receptor, Mouse 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR2_MOUSE P47936 CHEMBL5373 Cannabinoid CB2 Receptor, Mouse 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
HCAR2_HUMAN Q8TDS4 CHEMBL3785 Nicotinic Acid Receptor 1, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
BKRB1_HUMAN P46663 CHEMBL4308 Bradykinin B1 Receptor, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
BKRB1_HUMAN P46663 CHEMBL4308 Bradykinin B1 Receptor, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM5_HUMAN P41594 CHEMBL3227 Metabotropic Glutamate Receptor 5, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM5_HUMAN P41594 CHEMBL3227 Metabotropic Glutamate Receptor 5, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ENV_HV1Y2 P35961 CHEMBL6180 Envelope Glycoprotein Gp160, Hv1y2 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ENV_HV1Y2 P35961 CHEMBL6180 Envelope Glycoprotein Gp160, Hv1y2 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
NK3R_HUMAN P29371 CHEMBL4429 Neurokinin 3 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
TRPV1_HUMAN Q8NER1 CHEMBL4794 Vanilloid Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA3R_RAT P28647 CHEMBL3360 Adenosine A3 Receptor, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADK_HUMAN P55263 CHEMBL3589 Adenosine Kinase, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADK_HUMAN P55263 CHEMBL3589 Adenosine Kinase, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
DGAT1_HUMAN O75907 CHEMBL6009 Diacylglycerol O-acyltransferase 1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM1_HUMAN Q13255 CHEMBL3772 Metabotropic Glutamate Receptor 1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM1_RAT P23385 CHEMBL4477 Metabotropic Glutamate Receptor 1, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM1_RAT P23385 CHEMBL4477 Metabotropic Glutamate Receptor 1, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNA3_HUMAN P22001 CHEMBL4633 Voltage-gated Potassium Channel Subunit Kv1.3, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNA3_HUMAN P22001 CHEMBL4633 Voltage-gated Potassium Channel Subunit Kv1.3, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNA5_HUMAN P22460 CHEMBL4306 Voltage-gated Potassium Channel Subunit Kv1.5, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNA5_HUMAN P22460 CHEMBL4306 Voltage-gated Potassium Channel Subunit Kv1.5, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
NPY5R_HUMAN Q15761 CHEMBL4561 Neuropeptide Y Receptor Type 5, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OXGR1_RAT Q6Y1R5 CHEMBL2325 G Protein-coupled Receptor 80, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OXGR1_RAT Q6Y1R5 CHEMBL2325 G Protein-coupled Receptor 80, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Q8JXU8_9HEPC Q8JXU8 CHEMBL5375 Hepatitis C Virus NS5B RNA-dependent RNA Polymerase, 9hepc 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Q8JXU8_9HEPC Q8JXU8 CHEMBL5375 Hepatitis C Virus NS5B RNA-dependent RNA Polymerase, 9hepc 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Q8JXU8_9HEPC Q8JXU8 CHEMBL5375 Hepatitis C Virus NS5B RNA-dependent RNA Polymerase, 9hepc 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
QPCT_HUMAN Q16769 CHEMBL4508 Glutaminyl-peptide Cyclotransferase, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A9_HUMAN P48067 CHEMBL2337 Glycine Transporter 1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A9_HUMAN P48067 CHEMBL2337 Glycine Transporter 1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50652 Z50652 CHEMBL613740 Influenza A Virus 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80169 Z80169 CHEMBL614039 Huh-7 (Hepatocellular Carcinoma) 1 Annotations Catalogs SMILES SDF Mol2 Flexibase