ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (2,756)
Reactome (2)
Related By:
Pathway (27)
Organism (3)
Gene (0)
Org. Clust. (2)
ChEMBL (152)
Rings (50)

Delta Opioid Receptor, Human (2,756 Compounds)

Swissprot:: OPRD_HUMAN
Stitch:: OPRD_HUMAN
UniProt:: P41143
ChEMBL:: CHEMBL236
Reactome:: REACT_19231; REACT_14819
PDB:: 1OZC (DOCK); 2IQM (DOCK); OPRD1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	2,756	80	45	46
Binding ≤ 1μM	2,115	60	34	40
Functional ≤ 10μM	222	7	8	5

Reactome ID	Description	Species
REACT_19231	G alpha (i) signalling events	Homo sapiens
REACT_14819	Peptide ligand-binding receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	5
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	4
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	2
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	2
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	3
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	1
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	5
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	5
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	3
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	4
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	3
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	1
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	11
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	15
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	10
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	1
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2005
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2244
OPRX_HUMAN	P41146	CHEMBL2014	Nociceptin Receptor, Human	385
PDYN_HUMAN	P01213	CHEMBL2227	Proenkephalin B, Human	1
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	1

Peptide ligand-binding receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	1
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2005
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2244
OPRX_HUMAN	P41146	CHEMBL2014	Nociceptin Receptor, Human	385
PDYN_HUMAN	P01213	CHEMBL2227	Proenkephalin B, Human	1
UR2R_HUMAN	Q9UKP6	CHEMBL3764	Urotensin II Receptor, Human	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
OPRD_MOUSE	P32300	CHEMBL3222	Delta Opioid Receptor, Mouse	359	21	12	16
OPRD_PIG	P79291	CHEMBL4103	Delta Opioid Receptor, Pig	187	4	4	1
OPRD_RAT	P33533	CHEMBL269	Delta Opioid Receptor, Rat	1,915	66	39	51

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	4,915	142	74	93
OPRD-2-E	Delta Opioid Receptor (cluster #2 Of 3), Eukaryotic	1	0	1	1
OPRD-3-E	Delta Opioid Receptor (cluster #3 Of 3), Eukaryotic	4	2	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2239
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2005
OPRX_HUMAN	P41146	CHEMBL2014	Nociceptin Receptor, Human	385
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	276
OPRK_CAVPO	P41144	CHEMBL3952	Kappa Opioid Receptor, Guinea Pig	182
OPRD_RAT	P33533	CHEMBL269	Delta Opioid Receptor, Rat	134
OPRM_CAVPO	P97266	CHEMBL4354	Mu Opioid Receptor, Guinea Pig	112
OPRM_MOUSE	P42866	CHEMBL2858	Mu Opioid Receptor, Mouse	83
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	67
OPRD_MOUSE	P32300	CHEMBL3222	Delta Opioid Receptor, Mouse	56
OPRD_PIG	P79291	CHEMBL4103	Delta Opioid Receptor, Pig	55
OPRM_BOVIN	P79350	CHEMBL3041	Mu Opioid Receptor, Bovin	43
OPRK_RAT	P34975	CHEMBL3614	Kappa Opioid Receptor, Rat	41
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	40
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	28
OPRK_MOUSE	P33534	CHEMBL4329	Kappa Opioid Receptor, Mouse	23
Z104302	Z104302	CHEMBL1907608	Glutamate NMDA Receptor	23
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	15
Z50512	Z50512	CHEMBL369	Cavia Porcellus	14
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	13
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	13
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	13
SGMR1_MOUSE	O55242	CHEMBL3465	Sigma Opioid Receptor, Mouse	13
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	11
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	10
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	10
Z50594	Z50594	CHEMBL375	Mus Musculus	10
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	9
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	9
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	9
CAC1C_HUMAN	Q13936	CHEMBL1940	Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human	8
CAC1D_HUMAN	Q01668	CHEMBL4138	Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human	8
CAC1F_HUMAN	O60840	CHEMBL5593	Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human	8
CAC1S_HUMAN	Q13698	CHEMBL3805	Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human	8
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	8
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	8
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	7
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	7
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	6
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	6
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	6
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	5
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	5
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	5
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	5
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	5
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	4
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	4
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	4
NMD3B_RAT	Q8VHN2	CHEMBL282	Glutamate [NMDA] Receptor Subunit 3B, Rat	4
NMDE2_RAT	Q00960	CHEMBL311	Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat	4
NMDE3_RAT	Q00961	CHEMBL401	Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat	4
NMDE4_RAT	Q62645	CHEMBL303	Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat	4
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	3
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	3
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	3
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	3
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	3
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	3
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	3
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	3
SGMR1_CAVPO	Q60492	CHEMBL4153	Sigma-1 Receptor, Guinea Pig	3
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	2
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	2
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
CAC1G_HUMAN	O43497	CHEMBL4641	Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human	2
CAC1S_RAT	Q02485	CHEMBL4108	Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Rat	2
CCKAR_RAT	P30551	CHEMBL2871	Cholecystokinin A Receptor, Rat	2
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	2
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	2
OPRX_RAT	P35370	CHEMBL4503	Nociceptin Receptor, Rat	2
Q8CGM4_CAVPO	Q8CGM4	CHEMBL5430	Mu-opioid Receptor, Guinea Pig	2
SCN2A_RAT	P04775	CHEMBL3399	Sodium Channel Protein Type II Alpha Subunit, Rat	2
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	2
Z100254	Z100254	CHEMBL613295	Monoclonal Antibody (mAb) 3E7	2
5HT1D_PIG	P79400	CHEMBL4105	Serotonin 1d (5-HT1d) Receptor, Pig	1
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	1
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	1
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	1
AOFB_HUMAN	P27338	CHEMBL2039	Monoamine Oxidase B, Human	1
BACE1_HUMAN	P56817	CHEMBL4822	Beta-secretase 1, Human	1
CA2D1_RAT	P54290	CHEMBL3420	Voltage-gated Calcium Channel Alpha2/delta Subunit 1, Rat	1
CAC1B_HUMAN	Q00975	CHEMBL4478	Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human	1
CAC1B_RAT	Q02294	CHEMBL5107	Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Rat	1
CAC1H_HUMAN	O95180	CHEMBL1859	Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human	1
CAC1I_HUMAN	Q9P0X4	CHEMBL5558	Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human	1
CACB1_RAT	P54283	CHEMBL1075136	Voltage-dependent L-type Calcium Channel Subunit Beta-1, Rat	1
CCR5_MOUSE	P51682	CHEMBL3676	C-C Chemokine Receptor Type 5, Mouse	1
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	1
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	1
DRD2_BOVIN	P20288	CHEMBL3998	Dopamine D2 Receptor, Bovin	1
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	1
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	1
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	1
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	1
GBRA1_HUMAN	P14867	CHEMBL1962	GABA Receptor Alpha-1 Subunit, Human	1
GBRA2_HUMAN	P47869	CHEMBL4956	GABA Receptor Alpha-2 Subunit, Human	1
GBRA3_HUMAN	P34903	CHEMBL3026	GABA Receptor Alpha-3 Subunit, Human	1
GBRA4_HUMAN	P48169	CHEMBL2472	GABA Receptor Alpha-4 Subunit, Human	1
GBRA5_HUMAN	P31644	CHEMBL5112	GABA Receptor Alpha-5 Subunit, Human	1
GBRA6_HUMAN	Q16445	CHEMBL2579	GABA Receptor Alpha-6 Subunit, Human	1
GBRB1_HUMAN	P18505	CHEMBL4558	GABA Receptor Beta-1 Subunit, Human	1
GBRB2_HUMAN	P47870	CHEMBL1920	GABA Receptor Beta-2 Subunit, Human	1
GBRB3_HUMAN	P28472	CHEMBL1847	GABA Receptor Beta-3 Subunit, Human	1
GBRD_HUMAN	O14764	CHEMBL3591	GABA Receptor Delta Subunit, Human	1
GBRE_HUMAN	P78334	CHEMBL4635	GABA Receptor Epsilon Subunit, Human	1
GBRG1_HUMAN	Q8N1C3	CHEMBL4044	GABA Receptor Gamma-1 Subunit, Human	1
GBRG2_HUMAN	P18507	CHEMBL1788	GABA Receptor Gamma-2 Subunit, Human	1
GBRG3_HUMAN	Q99928	CHEMBL2739	GABA Receptor Gamma-3 Subunit, Human	1
GBRP_HUMAN	O00591	CHEMBL3506	GABA Receptor Pi Subunit, Human	1
GBRT_HUMAN	Q9UN88	CHEMBL2843	GABA Receptor Theta Subunit, Human	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	1
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	1
NK1R_RAT	P14600	CHEMBL4027	Neurokinin 1 Receptor, Rat	1
NMD3A_HUMAN	Q8TCU5	CHEMBL4787	Glutamate [NMDA] Receptor Subunit 3A, Human	1
NMD3B_HUMAN	O60391	CHEMBL2913	Glutamate [NMDA] Receptor Subunit 3B, Human	1
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	1
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	1
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	1
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	1
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	1
P97706_RAT	P97706	CHEMBL4957	Sodium Channel Protein Type VI Alpha Subunit, Rat	1
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	1
PDYN_HUMAN	P01213	CHEMBL2227	Proenkephalin B, Human	1
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	1
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	1
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	1
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	1
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1
SC6A4_RAT	P31652	CHEMBL313	Serotonin Transporter, Rat	1
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	1
SCN1A_RAT	P04774	CHEMBL4906	Sodium Channel Protein Type I Alpha Subunit, Rat	1
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	1
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	1
SCN3A_RAT	P08104	CHEMBL4966	Sodium Channel Protein Type III Alpha Subunit, Rat	1
SCN5A_RAT	P15389	CHEMBL3866	Sodium Channel Protein Type V Alpha Subunit, Rat	1
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	1
SCN8A_RAT	O88420	CHEMBL2752	Sodium Channel Protein Type VIII Alpha Subunit, Rat	1
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	1
TSPOB_HUMAN	B1AH88	CHEMBL5139	Peripheral-type Benzodiazepine Receptor, Human	1
UR2R_HUMAN	Q9UKP6	CHEMBL3764	Urotensin II Receptor, Human	1
Z100491	Z100491	CHEMBL613288	Sigma 2 Receptor	1
Z104288	Z104288	CHEMBL1907594	Neuronal Acetylcholine Receptor; Alpha3/beta4	1
Z104301	Z104301	CHEMBL1907607	GABA-A Receptor; Anion Channel	1
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	1
Z50466	Z50466	CHEMBL368	Trypanosoma Cruzi	1