UCSF

Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human (149 Compounds)

Swissprot:
CAC1C_HUMAN
Stitch:
CAC1C_HUMAN
UniProt:
Q13936
ChEMBL:
CHEMBL1940
Reactome:
REACT_18339
REACT_18312
REACT_18325
PDB:
1T0J (DOCK)
2BE6 (DOCK)
2F3Y (DOCK)
2F3Z (DOCK)
3G43 (DOCK)
3OXQ (DOCK)
CACNA1C

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 149 14 7 6
Binding ≤ 1μM 105 13 7 6
Functional ≤ 10μM 209 6 5 6

Reactome Network (3)

Reactome ID Description Species
REACT_18339 Adrenaline,noradrenaline inhibits insulin secretion Homo sapiens
REACT_18312 NCAM1 interactions Homo sapiens
REACT_18325 Regulation of insulin secretion Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 267

NCAM1 interactions

Uniprot Swissprot Chembl Description Number Shared
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 267
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 3
CAC1I_HUMAN Q9P0X4 CHEMBL5558 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human 1
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 165

Regulation of insulin secretion

Uniprot Swissprot Chembl Description Number Shared
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 267
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CAC1C_MOUSE Q01815 CHEMBL2529 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Mouse 5 0 0 0
CAC1C_RABIT P15381 CHEMBL2830 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rabit 19 2 2 2
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 331 25 20 22

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 267
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 164
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 107
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 81
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 36
Z50512 Z50512 CHEMBL369 Cavia Porcellus 32
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 18
SCN5A_HUMAN Q14524 CHEMBL1980 Sodium Channel Protein Type V Alpha Subunit, Human 17
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 15
CA2D1_HUMAN P54289 CHEMBL1919 Voltage-gated Calcium Channel Alpha2/delta Subunit 1, Human 13
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 12
HYES_HUMAN P34913 CHEMBL2409 Epoxide Hydratase, Human 12
HYES_RAT P80299 CHEMBL5669 Epoxide Hydrolase 2, Rat 12
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 12
CAC1S_RAT Q02485 CHEMBL4108 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Rat 11
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 11
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 11
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 10
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 9
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 9
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 9
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 9
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 9
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 8
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 8
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 8
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 7
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 7
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 7
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 7
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 6
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 6
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 6
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 5
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 5
SCN7A_HUMAN Q01118 CHEMBL3585 Sodium Channel Protein Type VII Alpha Subunit, Human 5
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 5
HYEP_HUMAN P07099 CHEMBL1968 Epoxide Hydrolase 1, Human 4
OPRX_HUMAN P41146 CHEMBL2014 Nociceptin Receptor, Human 4
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 4
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 4
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 3
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 3
CAC1D_RAT P27732 CHEMBL4132 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat 3
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 3
SCN9A_HUMAN Q15858 CHEMBL4296 Sodium Channel Protein Type IX Alpha Subunit, Human 3
TRPA1_MOUSE Q8BLA8 CHEMBL1075310 Transient Receptor Potential Cation Channel Subfamily A Member 1, Mouse 3
Z102306 Z102306 CHEMBL613606 Aorta 3
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
CAC1C_RABIT P15381 CHEMBL2830 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rabit 2
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 2
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 2
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 2
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 2
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 2
Z80387 Z80387 CHEMBL612556 PC-12 (Adrenal Phaeochromacytoma Cells) 2
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 1
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA3R_RAT P28647 CHEMBL3360 Adenosine A3 Receptor, Rat 1
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 1
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 1
AGTR1_HUMAN P30556 CHEMBL227 Angiotensin II Type 1 Receptor, Human 1
CAC1A_RAT P54282 CHEMBL4417 Voltage-gated P/Q-type Calcium Channel Alpha-1A Subunit, Rat 1
CAC1B_RAT Q02294 CHEMBL5107 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Rat 1
CAC1E_RAT Q07652 CHEMBL4115 Voltage-gated R-type Calcium Channel Alpha-1E Subunit, Rat 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1G_RAT O54898 CHEMBL4257 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Rat 1
CAC1H_RAT Q9EQ60 CHEMBL5134 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Rat 1
CAC1I_HUMAN Q9P0X4 CHEMBL5558 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human 1
CAC1I_RAT Q9Z0Y8 CHEMBL5459 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Rat 1
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 1
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 1
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 1
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 1
FFAR1_HUMAN O14842 CHEMBL4422 Free Fatty Acid Receptor 1, Human 1
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
KCNA5_HUMAN P22460 CHEMBL4306 Voltage-gated Potassium Channel Subunit Kv1.5, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
NK1R_MOUSE P30548 CHEMBL2668 Neurokinin 1 Receptor, Mouse 1
NK1R_RAT P14600 CHEMBL4027 Neurokinin 1 Receptor, Rat 1
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 1
P97706_RAT P97706 CHEMBL4957 Sodium Channel Protein Type VI Alpha Subunit, Rat 1
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 1
S22A1_HUMAN O15245 CHEMBL5685 Solute Carrier Family 22 Member 1, Human 1
SCN4A_HUMAN P35499 CHEMBL2072 Sodium Channel Protein Type IV Alpha Subunit, Human 1
SCN5A_RAT P15389 CHEMBL3866 Sodium Channel Protein Type V Alpha Subunit, Rat 1
SCNAA_HUMAN Q9Y5Y9 CHEMBL5451 Sodium Channel Protein Type X Alpha Subunit, Human 1
SCNBA_HUMAN Q9UI33 CHEMBL5167 Sodium Channel Protein Type XI Alpha Subunit, Human 1
TSPO_RAT P16257 CHEMBL4552 Peripheral-type Benzodiazepine Receptor, Rat 1
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 1
Z102372 Z102372 CHEMBL613672 Aorta 1
Z102380 Z102380 CHEMBL613680 Ileum 1
Z50590 Z50590 CHEMBL613488 Sus Scrofa 1
Z50740 Z50740 CHEMBL612361 Cricetinae Gen. Sp. 1
Z80051 Z80051 CHEMBL614532 C6-BU-1 1
Z80133 Z80133 CHEMBL614294 EMT6 (Mammary Carcinoma Cells) 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80232 Z80232 CHEMBL614128 MCF7-VP 1
Z80362 Z80362 CHEMBL389 P388 (Lymphoma Cells) 1
Z80364 Z80364 CHEMBL614218 P388/ADR (Lymphoma Cells) 1
Z80532 Z80532 CHEMBL614774 T-24 (Bladder Carcinoma Cells) 1
Z80711 Z80711 CHEMBL613829 NCI/ADR-RES (Breast Carcinoma Cells) 1
Z80773 Z80773 CHEMBL614456 CHRC/5 Cell Line 1
Z80774 Z80774 CHEMBL614457 CHRC5 Cell Line 1
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 1
Z81008 Z81008 CHEMBL614788 Human Breast Cancer Cell Lines 1
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 1

Most Common Rings