UCSF

Multidrug Resistance-associated Protein 1, Human (127 Compounds)

Swissprot:
MRP1_HUMAN
Stitch:
MRP1_HUMAN
UniProt:
P33527
ChEMBL:
CHEMBL3004
Reactome:
REACT_15480
REACT_163862
REACT_150420
PDB:
2CBZ (DOCK)
ABCC1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 127 20 18 10
Binding ≤ 1μM 80 5 5 4
Functional ≤ 10μM 25 0 1 1

Reactome Network (3)

Reactome ID Description Species
REACT_15480 ABC-family proteins mediated transport Homo sapiens
REACT_163862 Cobalamin (Cbl, vitamin B12) transport and metabolism Homo sapiens
REACT_150420 Synthesis of Leukotrienes (LT) and Eoxins (EX) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 8
MRP2_HUMAN Q92887 CHEMBL5748 Canalicular Multispecific Organic Anion Transporter 1, Human 3
MRP3_HUMAN O15438 CHEMBL5918 Canalicular Multispecific Organic Anion Transporter 2, Human 1

Cobalamin (Cbl, vitamin B12) transport and metabolism

Uniprot Swissprot Chembl Description Number Shared
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1

Synthesis of Leukotrienes (LT) and Eoxins (EX)

Uniprot Swissprot Chembl Description Number Shared
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MRP1_MOUSE O35379 CHEMBL2532 Multidrug Resistance-associated Protein 1, Mouse 5 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MRP2_HUMAN Q92887 CHEMBL5748 Canalicular Multispecific Organic Anion Transporter 1, Human 4 4 4 2
MRP3_HUMAN O15438 CHEMBL5918 Canalicular Multispecific Organic Anion Transporter 2, Human 1 1 1 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 37
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 32
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 7
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 7
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 6
MRP1_MOUSE O35379 CHEMBL2532 Multidrug Resistance-associated Protein 1, Mouse 5
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 4
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 4
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 3
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 3
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 3
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 3
MRP2_HUMAN Q92887 CHEMBL5748 Canalicular Multispecific Organic Anion Transporter 1, Human 3
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 3
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 2
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 2
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 2
CLTR2_HUMAN Q9NS75 CHEMBL4330 Cysteinyl Leukotriene Receptor 2, Human 2
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 2
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 2
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 2
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 2
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 2
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 2
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 2
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 2
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 2
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AHR_HUMAN P35869 CHEMBL3201 Aryl Hydrocarbon Receptor, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1C1_HUMAN Q04828 CHEMBL5905 Aldo-keto Reductase Family 1 Member C1, Human 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1C_RABIT P15381 CHEMBL2830 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rabit 1
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1D_RAT P27732 CHEMBL4132 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat 1
CAC1S_RAT Q02485 CHEMBL4108 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Rat 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
FPS_FUJSV P00530 CHEMBL5708 Tyrosine-protein Kinase Transforming Protein FPS, Fujsv 1
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
KD4DL_HUMAN B2RXH2 CHEMBL1293226 Lysine-specific Demethylase 4D-like, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MRP3_HUMAN O15438 CHEMBL5918 Canalicular Multispecific Organic Anion Transporter 2, Human 1
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
P97706_RAT P97706 CHEMBL4957 Sodium Channel Protein Type VI Alpha Subunit, Rat 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
S22A1_HUMAN O15245 CHEMBL5685 Solute Carrier Family 22 Member 1, Human 1
S22AC_HUMAN Q96S37 CHEMBL6120 Solute Carrier Family 22 Member 12, Human 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN5A_RAT P15389 CHEMBL3866 Sodium Channel Protein Type V Alpha Subunit, Rat 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
TSPO_RAT P16257 CHEMBL4552 Peripheral-type Benzodiazepine Receptor, Rat 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 1
Z80133 Z80133 CHEMBL614294 EMT6 (Mammary Carcinoma Cells) 1

Most Common Rings