UCSF

Monoamine Oxidase A, Human (437 Compounds)

Swissprot:
AOFA_HUMAN
Stitch:
AOFA_HUMAN
UniProt:
P21397
ChEMBL:
CHEMBL1951
Reactome:
REACT_15548
REACT_15511
REACT_15532
REACT_416
REACT_15418
PDB:
1H8Q (DOCK)
2BXR (DOCK)
2BXS (DOCK)
2Z5X (DOCK)
2Z5Y (DOCK)
MAOA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 437 102 46 17
Binding ≤ 1μM 249 45 22 9

Reactome Network (5)

Reactome ID Description Species
REACT_15548 Enzymatic degradation of dopamine by COMT Homo sapiens
REACT_15511 Enzymatic degradation of Dopamine by monoamine oxidase Homo sapiens
REACT_15532 Metabolism of serotonin Homo sapiens
REACT_416 Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 Homo sapiens
REACT_15418 Norepinephrine Neurotransmitter Release Cycle Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ALDH2_HUMAN P05091 CHEMBL1935 Aldehyde Dehydrogenase, Human 21

Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2

Uniprot Swissprot Chembl Description Number Shared
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 243
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 173 66 8 5
AOFA_RAT P21396 CHEMBL3358 Monoamine Oxidase A, Rat 619 148 24 19

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
AOFA-1-E Monoamine Oxidase A (cluster #1 Of 8), Eukaryotic 225 93 17 15
AOFA-2-E Monoamine Oxidase A (cluster #2 Of 8), Eukaryotic 578 109 8 2
AOFA-3-E Monoamine Oxidase A (cluster #3 Of 8), Eukaryotic 33 13 2 2
AOFA-4-E Monoamine Oxidase A (cluster #4 Of 8), Eukaryotic 202 58 35 7
AOFA-5-E Monoamine Oxidase A (cluster #5 Of 8), Eukaryotic 22 6 1 1
AOFA-6-E Monoamine Oxidase A (cluster #6 Of 8), Eukaryotic 123 15 1 0
AOFA-7-E Monoamine Oxidase A (cluster #7 Of 8), Eukaryotic 1 1 1 0
AOFA-8-E Monoamine Oxidase A (cluster #8 Of 8), Eukaryotic 21 4 2 2
Uniprot Swissprot Chembl Description Number Shared
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 243
AOFA_RAT P21396 CHEMBL3358 Monoamine Oxidase A, Rat 40
AOFB_RAT P19643 CHEMBL2993 Monoamine Oxidase B, Rat 39
ALDH2_HUMAN P05091 CHEMBL1935 Aldehyde Dehydrogenase, Human 19
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 11
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 8
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 6
O82865_MICLU O82865 CHEMBL4529 Tyramine Oxidase, Miclu 6
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 5
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 5
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 5
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 5
AOC3_RAT O08590 CHEMBL4592 Amine Oxidase, Copper Containing, Rat 5
AOFB_BOVIN P56560 CHEMBL2756 Monoamine Oxidase B, Bovin 5
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 5
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 4
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 4
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 4
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 4
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 4
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 4
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 4
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 4
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 3
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 3
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 3
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 3
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 3
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 3
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 3
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 3
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 3
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 3
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 3
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 3
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 3
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 3
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 3
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 3
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 3
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 3
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 3
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 3
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 2
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 2
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 2
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 2
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 2
ADA2A_BOVIN Q28838 CHEMBL4744 Alpha-2a Adrenergic Receptor, Bovin 2
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 2
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 2
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 2
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 2
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 2
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 2
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 2
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 2
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 2
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 2
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 2
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 2
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 2
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 1
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
A6BR99_YERPE A6BR99 CHEMBL1075036 Yersiniabactin Siderophore Biosynthetic Protein, Yerpe 1
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CD38_HUMAN P28907 CHEMBL4660 Lymphocyte Differentiation Antigen CD38, Human 1
DHB3_HUMAN P37058 CHEMBL4234 Estradiol 17-beta-dehydrogenase 3, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 1
DYRK2_HUMAN Q92630 CHEMBL4376 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 2, Human 1
DYRK3_HUMAN O43781 CHEMBL4575 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 3, Human 1
ERR1_HUMAN P11474 CHEMBL3429 Estrogen-related Receptor Alpha, Human 1
ERR2_HUMAN O95718 CHEMBL3751 Estrogen-related Receptor Beta, Human 1
FABI_ECOLI P0AEK4 CHEMBL1857 Enoyl-[acyl-carrier-protein] Reductase, Ecoli 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX1_SOYBN P08170 CHEMBL4586 Seed Lipoxygenase-1, Soybn 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MGA_HUMAN O43451 CHEMBL2074 Maltase-glucoamylase, Human 1
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 1
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 1
OPRK_CAVPO P41144 CHEMBL3952 Kappa Opioid Receptor, Guinea Pig 1
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 1
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 1
TOP1_RAT Q9WUL0 CHEMBL1075164 DNA Topoisomerase 1, Rat 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1

Most Common Rings