UCSF

Adenosine A2a Receptor, Human (2,605 Compounds)

Swissprot:
AA2AR_HUMAN
Stitch:
AA2AR_HUMAN
UniProt:
P29274
ChEMBL:
CHEMBL251
Reactome:
REACT_18288
REACT_19327
REACT_11046
PDB:
1MMH (DOCK)
1UPE (DOCK)
2YDO (DOCK)
2YDV (DOCK)
3EML (DOCK)
3PWH (DOCK)
3QAK (DOCK)
3REY (DOCK)
3RFM (DOCK)
3VG9 (DOCK)
3VGA (DOCK)
ADORA2A

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,605 153 29 23
Binding ≤ 1μM 1,973 99 12 13
Functional ≤ 10μM 392 21 5 3

Reactome Network (3)

Uniprot Swissprot Chembl Description Number Shared
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 1777
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 975
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1085

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 975
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 1
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 1
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 3
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 1
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 1
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 1
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 18 9 3 3
AA2AR_MOUSE Q60613 CHEMBL2115 Adenosine A2a Receptor, Mouse 5 2 0 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 2,846 130 40 27

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
AA2AR-1-E Adenosine A2a Receptor (cluster #1 Of 4), Eukaryotic 4,969 188 36 30
AA2AR-2-E Adenosine A2a Receptor (cluster #2 Of 4), Eukaryotic 59 29 5 4
AA2AR-3-E Adenosine A2a Receptor (cluster #3 Of 4), Eukaryotic 121 25 12 4
AA2AR-4-E Adenosine A2a Receptor (cluster #4 Of 4), Eukaryotic 33 7 3 3
Uniprot Swissprot Chembl Description Number Shared
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 1766
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1069
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 856
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 372
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 326
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 209
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 140
AA3R_RAT P28647 CHEMBL3360 Adenosine A3 Receptor, Rat 81
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 18
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 17
AA1R_RABIT P34970 CHEMBL3947 Adenosine A1 Receptor, Rabit 15
AA3R_RABIT O02667 CHEMBL2603 Adenosine A3 Receptor, Rabit 15
Z50587 Z50587 CHEMBL372 Homo Sapiens 15
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 14
AA1R_MOUSE Q60612 CHEMBL3688 Adenosine A1 Receptor, Mouse 12
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 12
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 11
AA3R_MOUSE Q61618 CHEMBL1075269 Adenosine Receptor A3, Mouse 10
GBRA1_BOVIN P08219 CHEMBL3627 GABA Receptor Alpha-1 Subunit, Bovin 9
GBRA2_BOVIN P10063 CHEMBL2321 GABA Receptor Alpha-2 Subunit, Bovin 9
GBRA3_BOVIN P10064 CHEMBL3628 GABA Receptor Alpha-3 Subunit, Bovin 9
GBRA4_BOVIN P20237 CHEMBL3140 GABA Receptor Alpha-4 Subunit, Bovin 9
GBRB1_BOVIN P08220 CHEMBL2848 GABA Receptor Beta-1 Subunit, Bovin 9
GBRG2_BOVIN P22300 CHEMBL5138 GABA Receptor Gamma-2 Subunit, Bovin 9
OXGR1_RAT Q6Y1R5 CHEMBL2325 G Protein-coupled Receptor 80, Rat 8
Q4VQ11_PIG Q4VQ11 CHEMBL1075029 A1 Adenosine Receptor, Pig 7
Z50512 Z50512 CHEMBL369 Cavia Porcellus 7
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 6
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 6
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 6
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 6
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 6
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 6
AA2AR_MOUSE Q60613 CHEMBL2115 Adenosine A2a Receptor, Mouse 5
SAHH_HUMAN P23526 CHEMBL2664 Adenosylhomocysteinase, Human 5
Z100273 Z100273 CHEMBL612413 P3 Purinoceptor 5
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 3
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 3
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 3
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 3
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 3
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 3
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
AA1R_CHICK P49892 CHEMBL2114 Adenosine A1 Receptor, Chick 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 2
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 2
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 2
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 2
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 2
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z50588 Z50588 CHEMBL373 Canis Familiaris 2
AA2BR_MOUSE Q60614 CHEMBL2237 Adenosine A2b Receptor, Mouse 1
AA3R_BOVIN Q0VC81 CHEMBL1287626 Adenosine Receptor A3, Bovin 1
ACCN3_HUMAN Q9UHC3 CHEMBL5368 Amiloride-sensitive Cation Channel 3, Human 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 1
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 1
ADK_HUMAN P55263 CHEMBL3589 Adenosine Kinase, Human 1
ADK_RAT Q64640 CHEMBL2384 Adenosine Kinase, Rat 1
AOC3_RAT O08590 CHEMBL4592 Amine Oxidase, Copper Containing, Rat 1
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 1
AOFB_MOUSE Q8BW75 CHEMBL3050 Monoamine Oxidase B, Mouse 1
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 1
HIPK2_HUMAN Q9H2X6 CHEMBL4576 Homeodomain-interacting Protein Kinase 2, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
P4K2A_HUMAN Q9BTU6 CHEMBL2251 PI4-kinase Type II, Human 1
P4K2B_HUMAN Q8TCG2 CHEMBL3220 PI4-kinase Type II Beta, Human 1
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 1
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1
PI4KA_HUMAN P42356 CHEMBL3667 PI4-kinase Alpha Subunit, Human 1
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 1
S29A1_HUMAN Q99808 CHEMBL1997 Equilibrative Nucleoside Transporter 1, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN5A_HUMAN Q14524 CHEMBL1980 Sodium Channel Protein Type V Alpha Subunit, Human 1
SCN9A_HUMAN Q15858 CHEMBL4296 Sodium Channel Protein Type IX Alpha Subunit, Human 1
SCNAA_HUMAN Q9Y5Y9 CHEMBL5451 Sodium Channel Protein Type X Alpha Subunit, Human 1
SCNAA_MOUSE Q6QIY3 CHEMBL5158 Sodium Channel Protein Type 10 Subunit Alpha, Mouse 1
SCNAA_RAT Q62968 CHEMBL4017 Sodium Channel Protein Type X Alpha Subunit, Rat 1
SCNNA_HUMAN P37088 CHEMBL1791 Amiloride-sensitive Sodium Channel Alpha-subunit, Human 1
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 1
Z102306 Z102306 CHEMBL613606 Aorta 1
Z80945 Z80945 CHEMBL614735 HEp-2 (Laryngeal Carcinoma Cells) 1