ZINC 12

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Names
Compounds (2,605)
Reactome (3)
Related By:
Pathway (23)
Organism (3)
Gene (0)
Org. Clust. (3)
ChEMBL (128)
Rings (50)

Adenosine A2a Receptor, Human (2,605 Compounds)

Swissprot:: AA2AR_HUMAN
Stitch:: AA2AR_HUMAN
UniProt:: P29274
ChEMBL:: CHEMBL251
Reactome:: REACT_18288; REACT_19327; REACT_11046
PDB:: 1MMH (DOCK); 1UPE (DOCK); 2YDO (DOCK); 2YDV (DOCK); 3EML (DOCK); 3PWH (DOCK); 3QAK (DOCK); 3REY (DOCK); 3RFM (DOCK); 3VG9 (DOCK); 3VGA (DOCK); ADORA2A

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	2,605	153	29	23
Binding ≤ 1μM	1,973	99	12	13
Functional ≤ 10μM	392	21	5	3

Reactome ID	Description	Species
REACT_18288	Adenosine P1 receptors	Homo sapiens
REACT_19327	G alpha (s) signalling events	Homo sapiens
REACT_11046	NGF-independant TRKA activation	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	1777
AA2BR_HUMAN	P29275	CHEMBL255	Adenosine A2b Receptor, Human	975
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	1085

G alpha (s) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
AA2BR_HUMAN	P29275	CHEMBL255	Adenosine A2b Receptor, Human	975
ADCY1_HUMAN	Q08828	CHEMBL2899	Brain Adenylate Cyclase 1, Human	1
ADCY2_HUMAN	Q08462	CHEMBL3760	Adenylate Cyclase Type II, Human	1
ADCY3_HUMAN	O60266	CHEMBL3164	Adenylate Cyclase Type III, Human	1
ADCY5_HUMAN	O95622	CHEMBL3189	Adenylate Cyclase Type V, Human	1
ADCY6_HUMAN	O43306	CHEMBL3221	Adenylate Cyclase Type VI, Human	1
ADCY7_HUMAN	P51828	CHEMBL4922	Adenylate Cyclase Type VII, Human	1
ADCY8_HUMAN	P40145	CHEMBL2960	Adenylate Cyclase Type VIII, Human	1
ADCY9_HUMAN	O60503	CHEMBL2655	Adenylate Cyclase Type IX, Human	1
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	3
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
PDE3A_HUMAN	Q14432	CHEMBL241	Phosphodiesterase 3A, Human	1
PDE3B_HUMAN	Q13370	CHEMBL290	Phosphodiesterase 3B, Human	1
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	1
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	1
PDE4D_HUMAN	Q08499	CHEMBL288	Phosphodiesterase 4D, Human	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
AA2AR_CAVPO	P46616	CHEMBL2605	Adenosine A2a Receptor, Guinea Pig	18	9	3	3
AA2AR_MOUSE	Q60613	CHEMBL2115	Adenosine A2a Receptor, Mouse	5	2	0	1
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	2,846	130	40	27

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
AA2AR-1-E	Adenosine A2a Receptor (cluster #1 Of 4), Eukaryotic	4,969	188	36	30
AA2AR-2-E	Adenosine A2a Receptor (cluster #2 Of 4), Eukaryotic	59	29	5	4
AA2AR-3-E	Adenosine A2a Receptor (cluster #3 Of 4), Eukaryotic	121	25	12	4
AA2AR-4-E	Adenosine A2a Receptor (cluster #4 Of 4), Eukaryotic	33	7	3	3

Uniprot	Swissprot	Chembl	Description	Number Shared
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	1766
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	1069
AA2BR_HUMAN	P29275	CHEMBL255	Adenosine A2b Receptor, Human	856
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	372
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	326
AA1R_BOVIN	P28190	CHEMBL4975	Adenosine A1 Receptor, Bovin	209
AA2BR_RAT	P29276	CHEMBL2592	Adenosine A2b Receptor, Rat	140
AA3R_RAT	P28647	CHEMBL3360	Adenosine A3 Receptor, Rat	81
AA2AR_CAVPO	P46616	CHEMBL2605	Adenosine A2a Receptor, Guinea Pig	18
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	17
AA1R_RABIT	P34970	CHEMBL3947	Adenosine A1 Receptor, Rabit	15
AA3R_RABIT	O02667	CHEMBL2603	Adenosine A3 Receptor, Rabit	15
Z50587	Z50587	CHEMBL372	Homo Sapiens	15
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	14
AA1R_MOUSE	Q60612	CHEMBL3688	Adenosine A1 Receptor, Mouse	12
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	12
ADCY2_RAT	P26769	CHEMBL2958	Adenylate Cyclase Type II, Rat	11
AA3R_MOUSE	Q61618	CHEMBL1075269	Adenosine Receptor A3, Mouse	10
GBRA1_BOVIN	P08219	CHEMBL3627	GABA Receptor Alpha-1 Subunit, Bovin	9
GBRA2_BOVIN	P10063	CHEMBL2321	GABA Receptor Alpha-2 Subunit, Bovin	9
GBRA3_BOVIN	P10064	CHEMBL3628	GABA Receptor Alpha-3 Subunit, Bovin	9
GBRA4_BOVIN	P20237	CHEMBL3140	GABA Receptor Alpha-4 Subunit, Bovin	9
GBRB1_BOVIN	P08220	CHEMBL2848	GABA Receptor Beta-1 Subunit, Bovin	9
GBRG2_BOVIN	P22300	CHEMBL5138	GABA Receptor Gamma-2 Subunit, Bovin	9
OXGR1_RAT	Q6Y1R5	CHEMBL2325	G Protein-coupled Receptor 80, Rat	8
Q4VQ11_PIG	Q4VQ11	CHEMBL1075029	A1 Adenosine Receptor, Pig	7
Z50512	Z50512	CHEMBL369	Cavia Porcellus	7
ADCY3_RAT	P21932	CHEMBL4864	Adenylate Cyclase Type III, Rat	6
ADCY4_RAT	P26770	CHEMBL2879	Adenylate Cyclase Type IV, Rat	6
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate Cyclase Type V, Rat	6
ADCY6_RAT	Q03343	CHEMBL2975	Adenylate Cyclase Type VI, Rat	6
ADCY8_RAT	P40146	CHEMBL3082	Adenylate Cyclase Type VIII, Rat	6
Z100081	Z100081	CHEMBL613107	PBMC (Peripheral Blood Mononuclear Cells)	6
AA2AR_MOUSE	Q60613	CHEMBL2115	Adenosine A2a Receptor, Mouse	5
SAHH_HUMAN	P23526	CHEMBL2664	Adenosylhomocysteinase, Human	5
Z100273	Z100273	CHEMBL612413	P3 Purinoceptor	5
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	3
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	3
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	3
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	3
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	3
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	3
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	2
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
AA1R_CHICK	P49892	CHEMBL2114	Adenosine A1 Receptor, Chick	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	2
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	2
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	2
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	2
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	2
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	2
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
Q72874_9HIV1	Q72874	CHEMBL243	Human Immunodeficiency Virus Type 1 Protease, 9hiv1	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	2
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	2
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
Z50588	Z50588	CHEMBL373	Canis Familiaris	2
AA2BR_MOUSE	Q60614	CHEMBL2237	Adenosine A2b Receptor, Mouse	1
AA3R_BOVIN	Q0VC81	CHEMBL1287626	Adenosine Receptor A3, Bovin	1
ACCN3_HUMAN	Q9UHC3	CHEMBL5368	Amiloride-sensitive Cation Channel 3, Human	1
ADCY1_HUMAN	Q08828	CHEMBL2899	Brain Adenylate Cyclase 1, Human	1
ADCY2_HUMAN	Q08462	CHEMBL3760	Adenylate Cyclase Type II, Human	1
ADCY3_HUMAN	O60266	CHEMBL3164	Adenylate Cyclase Type III, Human	1
ADCY5_HUMAN	O95622	CHEMBL3189	Adenylate Cyclase Type V, Human	1
ADCY6_HUMAN	O43306	CHEMBL3221	Adenylate Cyclase Type VI, Human	1
ADCY7_HUMAN	P51828	CHEMBL4922	Adenylate Cyclase Type VII, Human	1
ADCY8_HUMAN	P40145	CHEMBL2960	Adenylate Cyclase Type VIII, Human	1
ADCY9_HUMAN	O60503	CHEMBL2655	Adenylate Cyclase Type IX, Human	1
ADK_HUMAN	P55263	CHEMBL3589	Adenosine Kinase, Human	1
ADK_RAT	Q64640	CHEMBL2384	Adenosine Kinase, Rat	1
AOC3_RAT	O08590	CHEMBL4592	Amine Oxidase, Copper Containing, Rat	1
AOFB_HUMAN	P27338	CHEMBL2039	Monoamine Oxidase B, Human	1
AOFB_MOUSE	Q8BW75	CHEMBL3050	Monoamine Oxidase B, Mouse	1
DYR1A_HUMAN	Q13627	CHEMBL2292	Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human	1
HIPK2_HUMAN	Q9H2X6	CHEMBL4576	Homeodomain-interacting Protein Kinase 2, Human	1
KC1A_HUMAN	P48729	CHEMBL2793	Casein Kinase I Alpha, Human	1
KC1D_HUMAN	P48730	CHEMBL2828	Casein Kinase I Delta, Human	1
P4K2A_HUMAN	Q9BTU6	CHEMBL2251	PI4-kinase Type II, Human	1
P4K2B_HUMAN	Q8TCG2	CHEMBL3220	PI4-kinase Type II Beta, Human	1
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	1
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	1
PDE4D_HUMAN	Q08499	CHEMBL288	Phosphodiesterase 4D, Human	1
PI4KA_HUMAN	P42356	CHEMBL3667	PI4-kinase Alpha Subunit, Human	1
PI4KB_HUMAN	Q9UBF8	CHEMBL3268	PI4-kinase Beta Subunit, Human	1
S29A1_HUMAN	Q99808	CHEMBL1997	Equilibrative Nucleoside Transporter 1, Human	1
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	1
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	1
SCN5A_HUMAN	Q14524	CHEMBL1980	Sodium Channel Protein Type V Alpha Subunit, Human	1
SCN9A_HUMAN	Q15858	CHEMBL4296	Sodium Channel Protein Type IX Alpha Subunit, Human	1
SCNAA_HUMAN	Q9Y5Y9	CHEMBL5451	Sodium Channel Protein Type X Alpha Subunit, Human	1
SCNAA_MOUSE	Q6QIY3	CHEMBL5158	Sodium Channel Protein Type 10 Subunit Alpha, Mouse	1
SCNAA_RAT	Q62968	CHEMBL4017	Sodium Channel Protein Type X Alpha Subunit, Rat	1
SCNNA_HUMAN	P37088	CHEMBL1791	Amiloride-sensitive Sodium Channel Alpha-subunit, Human	1
UROK_HUMAN	P00749	CHEMBL3286	Urokinase-type Plasminogen Activator, Human	1
Z102306	Z102306	CHEMBL613606	Aorta	1
Z80945	Z80945	CHEMBL614735	HEp-2 (Laryngeal Carcinoma Cells)	1