ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (365)
Reactome (1)
Related By:
Pathway (4)
Organism (3)
Gene (0)
Org. Clust. (4)
ChEMBL (138)
Rings (19)

Serotonin 3a (5-HT3a) Receptor, Human (365 Compounds)

Swissprot:: 5HT3A_HUMAN
Stitch:: 5HT3A_HUMAN
UniProt:: P46098
ChEMBL:: CHEMBL1899
Reactome:: REACT_25387
PDB:: HTR3A

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	365	101	25	23
Binding ≤ 1μM	303	72	21	20
Functional ≤ 10μM	100	22	3	6

Reactome ID	Description	Species
REACT_25387	Ligand-gated ion channel transport	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT3B_HUMAN	O95264	CHEMBL3895	Serotonin 3b (5-HT3b) Receptor, Human	255
5HT3C_HUMAN	Q8WXA8	CHEMBL4795	Serotonin 3c (5-HT3c) Receptor, Human	234
5HT3D_HUMAN	Q70Z44	CHEMBL4673	Serotonin 3d (5-HT3d) Receptor, Human	234
5HT3E_HUMAN	A5X5Y0	CHEMBL3812	Serotonin 3e (5-HT3e) Receptor, Human	211

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
5HT3A_CAVPO	O70212	CHEMBL3666	Serotonin 3a (5-HT3a) Receptor, Guinea Pig	12	2	2	2
5HT3A_MOUSE	P23979	CHEMBL4972	Serotonin 3a (5-HT3a) Receptor, Mouse	43	10	10	9
5HT3A_RAT	P35563	CHEMBL2411	Serotonin 3a (5-HT3a) Receptor, Rat	699	63	22	22

Clustered By Gene (0)

Clustered By Organism (4)

Code	Description	Substances	Purchasable	Natural	In Man
5HT3A-1-E	Serotonin 3a (5-HT3a) Receptor (cluster #1 Of 5), Eukaryotic	651	75	31	32
5HT3A-2-E	Serotonin 3a (5-HT3a) Receptor (cluster #2 Of 5), Eukaryotic	340	32	3	1
5HT3A-3-E	Serotonin 3a (5-HT3a) Receptor (cluster #3 Of 5), Eukaryotic	1	0	0	0
5HT3A-4-E	Serotonin 3a (5-HT3a) Receptor (cluster #4 Of 5), Eukaryotic	17	7	1	2
5HT3A-5-E	Serotonin 3a (5-HT3a) Receptor (cluster #5 Of 5), Eukaryotic	40	34	4	2

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT3B_HUMAN	O95264	CHEMBL3895	Serotonin 3b (5-HT3b) Receptor, Human	255
5HT3C_HUMAN	Q8WXA8	CHEMBL4795	Serotonin 3c (5-HT3c) Receptor, Human	234
5HT3D_HUMAN	Q70Z44	CHEMBL4673	Serotonin 3d (5-HT3d) Receptor, Human	234
5HT3E_HUMAN	A5X5Y0	CHEMBL3812	Serotonin 3e (5-HT3e) Receptor, Human	211
5HT3A_RAT	P35563	CHEMBL2411	Serotonin 3a (5-HT3a) Receptor, Rat	72
5HT3B_RAT	Q9JJ16	CHEMBL3458	Serotonin 3b (5-HT3b) Receptor, Rat	71
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	68
ACHA7_HUMAN	P36544	CHEMBL2492	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human	51
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	36
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	35
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	27
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	25
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	23
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	21
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	20
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	20
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	20
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	20
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	18
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	17
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	16
5HT4R_CAVPO	O70528	CHEMBL5017	Serotonin 4 (5-HT4) Receptor, Guinea Pig	15
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	15
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	14
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	12
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	12
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	10
5HT4R_RAT	Q62758	CHEMBL4317	Serotonin 4 (5-HT4) Receptor, Rat	10
ACHA7_RAT	Q05941	CHEMBL4980	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat	10
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	10
5HT1D_PIG	P79400	CHEMBL4105	Serotonin 1d (5-HT1d) Receptor, Pig	9
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	9
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	9
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	9
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	9
5HT1F_HUMAN	P30939	CHEMBL1805	Serotonin 1f (5-HT1f) Receptor, Human	8
5HT2A_BOVIN	Q75Z89	CHEMBL3446	Serotonin 2a (5-HT2a) Receptor, Bovin	8
5HT3A_CAVPO	O70212	CHEMBL3666	Serotonin 3a (5-HT3a) Receptor, Guinea Pig	8
5HT3B_MOUSE	Q9JHJ5	CHEMBL3781	Serotonin 3b (5-HT3b) Receptor, Mouse	8
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	8
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	8
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	8
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	8
5HT3A_MOUSE	P23979	CHEMBL4972	Serotonin 3a (5-HT3a) Receptor, Mouse	7
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	7
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	7
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	7
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	7
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	7
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	7
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	6
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	6
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	6
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	6
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	6
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	6
ACHA7_MOUSE	P49582	CHEMBL3365	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Mouse	5
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	5
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	5
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	5
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	5
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	5
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	4
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	4
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	4
CAC1G_HUMAN	O43497	CHEMBL4641	Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human	4
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	4
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	4
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	4
Z80334	Z80334	CHEMBL613828	NG108-15 (Neuroblastoma-glioma Hybrid Cells)	4
5HT5A_MOUSE	P30966	CHEMBL3597	Serotonin 5a (5-HT5a) Receptor, Mouse	3
ACHA3_HUMAN	P32297	CHEMBL3068	Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human	3
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	3
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	3
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	3
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	3
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	3
SC6A4_RAT	P31652	CHEMBL313	Serotonin Transporter, Rat	3
5HT1A_MOUSE	Q64264	CHEMBL3737	Serotonin 1a (5-HT1a) Receptor, Mouse	2
5HT2A_MOUSE	P35363	CHEMBL5377	Serotonin 2a (5-HT2a) Receptor, Mouse	2
5HT2B_MOUSE	Q02152	CHEMBL2583	Serotonin 2b (5-HT2b) Receptor, Mouse	2
5HT2C_MOUSE	P34968	CHEMBL3006	Serotonin 2c (5-HT2c) Receptor, Mouse	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
ACHA_HUMAN	P02708	CHEMBL4808	Acetylcholine Receptor Protein Alpha Chain, Human	2
ACM1_RAT	P08482	CHEMBL276	Muscarinic Acetylcholine Receptor M1, Rat	2
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	2
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	2
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	2
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CAC1C_RAT	P22002	CHEMBL3762	Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat	2
CAC1D_RAT	P27732	CHEMBL4132	Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
DRD1_PIG	P50130	CHEMBL5067	Dopamine D1 Receptor, Pig	2
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GASR_RAT	P30553	CHEMBL3508	Cholecystokinin B Receptor, Rat	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
HRH1_RAT	P31390	CHEMBL4701	Histamine H1 Receptor, Rat	2
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	2
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
UROK_HUMAN	P00749	CHEMBL3286	Urokinase-type Plasminogen Activator, Human	2
5HT5A_RAT	P35364	CHEMBL4655	Serotonin 5a (5-HT5a) Receptor, Rat	1
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	1
ACHA4_HUMAN	P43681	CHEMBL1882	Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Human	1
ACHP_LYMST	P58154	CHEMBL6084	Acetylcholine-binding Protein, Lymst	1
ADA1A_BOVIN	P18130	CHEMBL4892	Alpha-1a Adrenergic Receptor, Bovin	1
ADA2A_BOVIN	Q28838	CHEMBL4744	Alpha-2a Adrenergic Receptor, Bovin	1
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	1
CHLE_HUMAN	P06276	CHEMBL1914	Butyrylcholinesterase, Human	1
DRD2_MOUSE	P61168	CHEMBL3427	Dopamine D2 Receptor, Mouse	1
HNMT_RAT	Q01984	CHEMBL3241	Histamine N-methyltransferase, Rat	1
HRH1_CAVPO	P31389	CHEMBL3943	Histamine H1 Receptor, Guinea Pig	1
HRH3_CAVPO	Q9JI35	CHEMBL5076	Histamine H3 Receptor, Guinea Pig	1
SC6A3_RAT	P23977	CHEMBL338	Dopamine Transporter, Rat	1
SGMR1_CAVPO	Q60492	CHEMBL4153	Sigma-1 Receptor, Guinea Pig	1
SGMR1_MOUSE	O55242	CHEMBL3465	Sigma Opioid Receptor, Mouse	1
Z100491	Z100491	CHEMBL613288	Sigma 2 Receptor	1
Z104282	Z104282	CHEMBL1907588	Acetylcholine Receptor; Alpha1/beta1/delta/gamma	1
Z104290	Z104290	CHEMBL1907596	Neuronal Acetylcholine Receptor; Alpha4/beta2	1
Z104292	Z104292	CHEMBL1907598	Integrin Alpha-V/beta-3	1
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	1
Z50588	Z50588	CHEMBL373	Canis Familiaris	1
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	1