| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 140 | 21 | 4 | 4 |
| Binding ≤ 1μM | 99 | 21 | 4 | 4 |
| Functional ≤ 10μM | 17 | 4 | 3 | 1 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_22352 | Highly calcium permeable nicotinic acetylcholine receptors | Homo sapiens |
| REACT_22303 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | Homo sapiens |
| REACT_22223 | Highly sodium permeable acetylcholine nicotinic receptors | Homo sapiens |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ACHA2_HUMAN | Q15822 | CHEMBL1794 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human | 17 |
| ACHA3_HUMAN | P32297 | CHEMBL3068 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human | 59 |
| ACHA5_HUMAN | P30532 | CHEMBL2454 | Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Human | 5 |
| ACHA6_HUMAN | Q15825 | CHEMBL2356 | Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Human | 5 |
| ACHA_HUMAN | P02708 | CHEMBL4808 | Acetylcholine Receptor Protein Alpha Chain, Human | 8 |
| ACHB2_HUMAN | P17787 | CHEMBL1883 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human | 36 |
| ACHB3_HUMAN | Q05901 | CHEMBL2586 | Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Human | 25 |
| ACHB4_HUMAN | P30926 | CHEMBL3002 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human | 36 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ACHA2_HUMAN | Q15822 | CHEMBL1794 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human | 17 |
| ACHA3_HUMAN | P32297 | CHEMBL3068 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human | 59 |
| ACHA5_HUMAN | P30532 | CHEMBL2454 | Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Human | 5 |
| ACHA6_HUMAN | Q15825 | CHEMBL2356 | Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Human | 5 |
| ACHA7_HUMAN | P36544 | CHEMBL2492 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human | 32 |
| ACHA9_HUMAN | Q9UGM1 | CHEMBL2184 | Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Human | 1 |
| ACHA_HUMAN | P02708 | CHEMBL4808 | Acetylcholine Receptor Protein Alpha Chain, Human | 8 |
| ACHB2_HUMAN | P17787 | CHEMBL1883 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human | 36 |
| ACHB3_HUMAN | Q05901 | CHEMBL2586 | Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Human | 25 |
| ACHB4_HUMAN | P30926 | CHEMBL3002 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human | 36 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ACHA3_HUMAN | P32297 | CHEMBL3068 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human | 59 |
| ACHB2_HUMAN | P17787 | CHEMBL1883 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human | 36 |
| ACHB4_HUMAN | P30926 | CHEMBL3002 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human | 36 |
| ACHD_HUMAN | Q07001 | CHEMBL3011 | Acetylcholine Receptor Protein Delta Chain, Human | 6 |
| ACHE_HUMAN | Q04844 | CHEMBL2484 | Acetylcholine Receptor Protein Epsilon Chain, Human | 4 |
| ACHG_HUMAN | P07510 | CHEMBL2613 | Acetylcholine Receptor Protein Gamma Chain, Human | 4 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| ACHA4_CHICK | P09482 | CHEMBL5569 | Neuronal Acetylcholine Receptor Subunit Alpha-4, Chick | 4 | 2 | 2 | 2 |
| ACHA4_MOUSE | O70174 | CHEMBL4457 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Mouse | 17 | 8 | 5 | 1 |
| ACHA4_RAT | P09483 | CHEMBL307 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat | 472 | 78 | 25 | 10 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| ACHA2_HUMAN | Q15822 | CHEMBL1794 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human | 24 | 6 | 4 | 4 |
| ACHA3_HUMAN | P32297 | CHEMBL3068 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human | 84 | 15 | 7 | 7 |
| ACHA5_HUMAN | P30532 | CHEMBL2454 | Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Human | 5 | 3 | 1 | 0 |
| ACHA6_HUMAN | Q15825 | CHEMBL2356 | Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Human | 5 | 3 | 1 | 0 |
| ACHA7_HUMAN | P36544 | CHEMBL2492 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human | 142 | 31 | 15 | 10 |
| ACHA9_HUMAN | Q9UGM1 | CHEMBL2184 | Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Human | 1 | 1 | 0 | 0 |
| ACHA_HUMAN | P02708 | CHEMBL4808 | Acetylcholine Receptor Protein Alpha Chain, Human | 8 | 3 | 1 | 0 |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| ACHA4-1-E | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #1 Of 5), Eukaryotic | 338 | 72 | 22 | 10 |
| ACHA4-2-E | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #2 Of 5), Eukaryotic | 1 | 1 | 1 | 0 |
| ACHA4-3-E | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #3 Of 5), Eukaryotic | 117 | 17 | 1 | 1 |
| ACHA4-4-E | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #4 Of 5), Eukaryotic | 85 | 0 | 0 | 0 |
| ACHA4-5-E | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #5 Of 5), Eukaryotic | 80 | 9 | 5 | 2 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ACHA3_HUMAN | P32297 | CHEMBL3068 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human | 58 |
| Z104290 | Z104290 | CHEMBL1907596 | Neuronal Acetylcholine Receptor; Alpha4/beta2 | 55 |
| ACHB2_HUMAN | P17787 | CHEMBL1883 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human | 36 |
| ACHB4_HUMAN | P30926 | CHEMBL3002 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human | 36 |
| Z104283 | Z104283 | CHEMBL1907589 | Neuronal Acetylcholine Receptor; Alpha4/beta2 | 34 |
| ACHA7_HUMAN | P36544 | CHEMBL2492 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human | 31 |
| ACHB3_HUMAN | Q05901 | CHEMBL2586 | Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Human | 24 |
| ACHB2_RAT | P12390 | CHEMBL3001 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Rat | 18 |
| ACHA2_HUMAN | Q15822 | CHEMBL1794 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human | 17 |
| ACHB4_RAT | P12392 | CHEMBL2658 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Rat | 16 |
| ACHA4_RAT | P09483 | CHEMBL307 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat | 11 |
| ACHA3_RAT | P04757 | CHEMBL3818 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Rat | 10 |
| Z104287 | Z104287 | CHEMBL1907593 | Neuronal Acetylcholine Receptor; Alpha3/beta4 | 10 |
| ACHA7_RAT | Q05941 | CHEMBL4980 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat | 9 |
| ACHD_TORCA | P02718 | CHEMBL3916 | Acetylcholine Receptor Protein Delta Chain, Torca | 9 |
| ACHA_HUMAN | P02708 | CHEMBL4808 | Acetylcholine Receptor Protein Alpha Chain, Human | 8 |
| ACHA2_RAT | P12389 | CHEMBL2584 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Rat | 6 |
| ACHA9_RAT | P43144 | CHEMBL2585 | Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Rat | 6 |
| ACHD_HUMAN | Q07001 | CHEMBL3011 | Acetylcholine Receptor Protein Delta Chain, Human | 6 |
| ACH10_HUMAN | Q9GZZ6 | CHEMBL2551 | Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Human | 5 |
| ACHA5_HUMAN | P30532 | CHEMBL2454 | Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Human | 5 |
| ACHA6_HUMAN | Q15825 | CHEMBL2356 | Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Human | 5 |
| ACHA_TORCA | P02710 | CHEMBL3097 | Acetylcholine Receptor Protein Alpha Chain, Torca | 5 |
| Z104281 | Z104281 | CHEMBL1907587 | Neuronal Acetylcholine Receptor; Alpha3/beta2 | 5 |
| Z104286 | Z104286 | CHEMBL1907592 | Neuronal Acetylcholine Receptor; Alpha2/beta2 | 5 |
| Z104288 | Z104288 | CHEMBL1907594 | Neuronal Acetylcholine Receptor; Alpha3/beta4 | 5 |
| Z104289 | Z104289 | CHEMBL1907595 | Neuronal Acetylcholine Receptor; Alpha4/beta4 | 5 |
| ACH10_RAT | Q9JLB5 | CHEMBL3461 | Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Rat | 4 |
| ACHA5_RAT | P20420 | CHEMBL4960 | Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Rat | 4 |
| ACHA6_RAT | P43143 | CHEMBL4747 | Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Rat | 4 |
| ACHA_RAT | P25108 | CHEMBL3599 | Acetylcholine Receptor Protein Alpha Chain, Rat | 4 |
| ACHB3_RAT | P12391 | CHEMBL4568 | Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Rat | 4 |
| ACHB_HUMAN | P11230 | CHEMBL3355 | Acetylcholine Receptor Protein Beta Chain, Human | 4 |
| ACHB_RAT | P25109 | CHEMBL2666 | Acetylcholine Receptor Protein Beta Chain, Rat | 4 |
| ACHB_TORCA | P02712 | CHEMBL3803 | Acetylcholine Receptor Protein Beta Chain, Torca | 4 |
| ACHE_HUMAN | Q04844 | CHEMBL2484 | Acetylcholine Receptor Protein Epsilon Chain, Human | 4 |
| ACHG_HUMAN | P07510 | CHEMBL2613 | Acetylcholine Receptor Protein Gamma Chain, Human | 4 |
| ACHG_TORCA | P02714 | CHEMBL4019 | Acetylcholine Receptor Protein Gamma Chain, Torca | 4 |
| Z104282 | Z104282 | CHEMBL1907588 | Acetylcholine Receptor; Alpha1/beta1/delta/gamma | 4 |
| Z104284 | Z104284 | CHEMBL1907590 | Neuronal Acetylcholine Receptor; Alpha2/beta4 | 4 |
| Z81074 | Z81074 | CHEMBL614687 | K177cell Line | 4 |
| ACHA4_MOUSE | O70174 | CHEMBL4457 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Mouse | 3 |
| ACHP_LYMST | P58154 | CHEMBL6084 | Acetylcholine-binding Protein, Lymst | 3 |
| Q8BGP7_MOUSE | Q8BGP7 | CHEMBL2235 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Mouse | 3 |
| Z104285 | Z104285 | CHEMBL1907591 | Neuronal Acetylcholine Receptor; Alpha4/beta4 | 3 |
| Z50597 | Z50597 | CHEMBL376 | Rattus Norvegicus | 3 |
| Z80175 | Z80175 | CHEMBL614585 | IMR-32 (Neuroblastoma Cells) | 2 |
| Z80545 | Z80545 | CHEMBL615012 | TE-671 | 2 |
| 5HT3A_HUMAN | P46098 | CHEMBL1899 | Serotonin 3a (5-HT3a) Receptor, Human | 1 |
| ACHA4_CHICK | P09482 | CHEMBL5569 | Neuronal Acetylcholine Receptor Subunit Alpha-4, Chick | 1 |
| ACHA7_MOUSE | P49582 | CHEMBL3365 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Mouse | 1 |
| ACHA9_HUMAN | Q9UGM1 | CHEMBL2184 | Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Human | 1 |
| KCNH2_HUMAN | Q12809 | CHEMBL240 | HERG, Human | 1 |
| Z50594 | Z50594 | CHEMBL375 | Mus Musculus | 1 |