UCSF

Glucocorticoid Receptor, Human (1,714 Compounds)

Swissprot:
GCR_HUMAN
Stitch:
GCR_HUMAN
UniProt:
P04150
ChEMBL:
CHEMBL2034
Reactome:
REACT_111118
PDB:
1M2Z (DOCK)
1NHZ (DOCK)
1P93 (DOCK)
3BQD (DOCK)
3CLD (DOCK)
3E7C (DOCK)
3H52 (DOCK)
3K22 (DOCK)
3K23 (DOCK)
NR3C1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,714 39 22 10
Binding ≤ 1μM 1,536 36 16 10
Functional ≤ 10μM 950 16 9 10

Reactome Network (1)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GCR_MOUSE P06537 CHEMBL3144 Glucocorticoid Receptor, Mouse 15 1 1 1
GCR_RAT P06536 CHEMBL3368 Glucocorticoid Receptor, Rat 136 8 7 6

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
GCR-1-E Glucocorticoid Receptor (cluster #1 Of 2), Eukaryotic 1,603 10 7 1
GCR-2-E Glucocorticoid Receptor (cluster #2 Of 2), Eukaryotic 266 38 25 15
Uniprot Swissprot Chembl Description Number Shared
PRGR_HUMAN P06401 CHEMBL208 Progesterone Receptor, Human 722
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 404
MCR_HUMAN P08235 CHEMBL1994 Mineralocorticoid Receptor, Human 404
Z80110 Z80110 CHEMBL613507 CV-1 (Kidney Cells) 76
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 51
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 44
GCR_RAT P06536 CHEMBL3368 Glucocorticoid Receptor, Rat 37
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 29
Z50594 Z50594 CHEMBL375 Mus Musculus 22
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 22
MCR_RAT P22199 CHEMBL3507 Mineralocorticoid Receptor, Rat 19
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 19
GCR_MOUSE P06537 CHEMBL3144 Glucocorticoid Receptor, Mouse 16
ATTY_RAT P04694 CHEMBL5947 Tyrosine Aminotransferase, Rat 10
GLNA_HUMAN P15104 CHEMBL4612 Glutamine Synthetase, Human 8
NR1I2_HUMAN O75469 CHEMBL3401 Pregnane X Receptor, Human 7
Z81011 Z81011 CHEMBL614840 Human Cell Lines 5
ANDR_MOUSE P19091 CHEMBL3056 Androgen Receptor, Mouse 4
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 4
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 4
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 4
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 2
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 2
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
FABPL_RAT P02692 CHEMBL5738 Fatty Acid-binding Protein, Liver, Rat 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NR1H2_HUMAN P55055 CHEMBL4093 LXR-beta, Human 2
NR1H3_HUMAN Q13133 CHEMBL2808 LXR-alpha, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 2
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2
PRGR_CHICK P07812 CHEMBL3304 Progesterone Receptor, Chick 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 2
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 2
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2
VP16_HHV11 P06492 CHEMBL4218 Alpha Trans-inducing Protein (VP16), Hhv11 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z80712 Z80712 CHEMBL614361 T47D (Breast Carcinoma Cells) 2
Z80954 Z80954 CHEMBL614071 HFF (Foreskin Fibroblasts) 2
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
ESR1_RAT P06211 CHEMBL2724 Estrogen Receptor Alpha, Rat 1
ESR2_RAT Q62986 CHEMBL3021 Estrogen Receptor Beta, Rat 1
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1
NR1H4_MOUSE Q60641 CHEMBL5343 Bile Acid Receptor, Mouse 1
NTCP_RAT P26435 CHEMBL4847 Bile Acid Transporter, Rat 1
O46399_SHEEP O46399 CHEMBL3462 Beta Tubulin, Sheep 1
P96878_MYCTU P96878 CHEMBL5767 PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE), Myctu 1
PRGR_RABIT P06186 CHEMBL3456 Progesterone Receptor, Rabit 1
PRGR_RAT Q63449 CHEMBL2596 Progesterone Receptor, Rat 1
Q3I4V7_CRYNV Q3I4V7 CHEMBL1697676 Carbonic Anhydrase 2, Crynv 1
Q5AJ71_CANAL Q5AJ71 CHEMBL5337 Carbonic Anhydrase, Canal 1
Q862F3_BOVIN Q862F3 CHEMBL4262 Tubulin Alpha Chain, Bovin 1
Q862L2_BOVIN Q862L2 CHEMBL3752 Tubulin Alpha-1 Chain, Bovin 1
Q9MZB0_SHEEP Q9MZB0 CHEMBL4099 Tubulin Alpha-1 Chain, Sheep 1
S5A1_RAT P24008 CHEMBL3422 Steroid 5-alpha-reductase 1, Rat 1
S5A2_RAT P31214 CHEMBL5099 Steroid 5-alpha-reductase 2, Rat 1
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 1
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 1
TBA1A_PIG P02550 CHEMBL3658 Tubulin Alpha Chain, Pig 1
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 1
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 1
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 1
TBB2B_BOVIN Q6B856 CHEMBL3394 Tubulin Beta Chain, Bovin 1
TBB2B_RAT Q3KRE8 CHEMBL2984 Tubulin Beta Chain, Rat 1
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 1
TBB3_RAT Q4QRB4 CHEMBL4569 Tubulin Beta-3 Chain, Rat 1
TBB4A_HUMAN P04350 CHEMBL3838 Tubulin Beta-4 Chain, Human 1
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 1
TBB5_HUMAN P07437 CHEMBL5444 Tubulin Beta-5 Chain, Human 1
TBB8_HUMAN Q3ZCM7 CHEMBL4024 Tubulin Beta-8 Chain, Human 1
TBB_PIG P02554 CHEMBL2788 Tubulin Beta Chain, Pig 1
TBG1_RAT P83888 CHEMBL2881 Tubulin Gamma-1 Chain, Rat 1
THA_HUMAN P10827 CHEMBL1860 Thyroid Hormone Receptor Alpha, Human 1
VE2_HPV1A P03118 CHEMBL5822 Regulatory Protein E2, Hpv1a 1
Y1284_MYCTU P64797 CHEMBL5631 Uncharacterized Protein Rv1284/MT1322, Myctu 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 1
Z80178 Z80178 CHEMBL614040 J774.A1 (Macrophage Cells) 1
Z80301 Z80301 CHEMBL613516 N9 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80491 Z80491 CHEMBL614163 SK-N-MC (Neuroepithelioma Cells) 1
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 1
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 1
Z81338 Z81338 CHEMBL614309 T-cells 1