ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (2,709)
Reactome (2)
Related By:
Pathway (24)
Organism (3)
Gene (0)
Org. Clust. (1)
ChEMBL (113)
Rings (49)

Neurokinin 1 Receptor, Human (2,709 Compounds)

Swissprot:: NK1R_HUMAN
Stitch:: NK1R_HUMAN
UniProt:: P25103
ChEMBL:: CHEMBL249
Reactome:: REACT_18283; REACT_16963
PDB:: 2KS9 (DOCK); 2KSA (DOCK); 2KSB (DOCK); TACR1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	2,709	27	6	9
Binding ≤ 1μM	2,563	19	6	9
Functional ≤ 10μM	128	5	2	1

Reactome ID	Description	Species
REACT_18283	G alpha (q) signalling events	Homo sapiens
REACT_16963	Tachykinin receptors bind tachykinins	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	4
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	4
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	3
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	4
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	3
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	3
AGTR1_HUMAN	P30556	CHEMBL227	Angiotensin II Type 1 Receptor, Human	1
BKRB1_HUMAN	P46663	CHEMBL4308	Bradykinin B1 Receptor, Human	11
BKRB2_HUMAN	P30411	CHEMBL3157	Bradykinin B2 Receptor, Human	11
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GHSR_HUMAN	Q92847	CHEMBL4616	Ghrelin Receptor, Human	1
GNRHR_HUMAN	P30968	CHEMBL1855	Gonadotropin-releasing Hormone Receptor, Human	1
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	52
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	517
NK3R_HUMAN	P29371	CHEMBL4429	Neurokinin 3 Receptor, Human	119
NMBR_HUMAN	P28336	CHEMBL3636	Neuromedin B Receptor, Human	1
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OXYR_HUMAN	P30559	CHEMBL2049	Oxytocin Receptor, Human	1
PTAFR_HUMAN	P25105	CHEMBL250	Platelet Activating Factor Receptor, Human	1
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	1

Tachykinin receptors bind tachykinins

Uniprot	Swissprot	Chembl	Description	Number Shared
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	517
NK3R_HUMAN	P29371	CHEMBL4429	Neurokinin 3 Receptor, Human	119

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
NK1R_CAVPO	P30547	CHEMBL3942	Neurokinin 1 Receptor, Guinea Pig	14	0	0	0
NK1R_MOUSE	P30548	CHEMBL2668	Neurokinin 1 Receptor, Mouse	5	2	0	0
NK1R_RAT	P14600	CHEMBL4027	Neurokinin 1 Receptor, Rat	143	7	2	2

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
NK1R-1-E	Neurokinin 1 Receptor (cluster #1 Of 2), Eukaryotic	2,607	35	10	12
NK1R-2-E	Neurokinin 1 Receptor (cluster #2 Of 2), Eukaryotic	292	3	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	517
NK3R_HUMAN	P29371	CHEMBL4429	Neurokinin 3 Receptor, Human	119
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	95
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	52
NK1R_RAT	P14600	CHEMBL4027	Neurokinin 1 Receptor, Rat	47
NK2R_MOUSE	P30549	CHEMBL2813	Neurokinin 2 Receptor, Mouse	27
NK2R_RAT	P16610	CHEMBL4554	Neurokinin 2 Receptor, Rat	22
CAC1F_HUMAN	O60840	CHEMBL5593	Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human	17
CAC1S_HUMAN	Q13698	CHEMBL3805	Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human	17
BKRB1_HUMAN	P46663	CHEMBL4308	Bradykinin B1 Receptor, Human	11
BKRB2_HUMAN	P30411	CHEMBL3157	Bradykinin B2 Receptor, Human	11
CAC1C_HUMAN	Q13936	CHEMBL1940	Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human	9
CAC1D_HUMAN	Q01668	CHEMBL4138	Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human	9
NK3R_RAT	P16177	CHEMBL3154	Neurokinin 3 Receptor, Rat	8
CAC1S_RAT	Q02485	CHEMBL4108	Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Rat	7
NK3R_CAVPO	P30098	CHEMBL3799	Neurokinin 3 Receptor, Guinea Pig	7
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	5
NK1R_MOUSE	P30548	CHEMBL2668	Neurokinin 1 Receptor, Mouse	5
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	5
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	4
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	4
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	4
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	4
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	4
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	4
AGTR2_RAT	P35351	CHEMBL257	Angiotensin II Type 2 (AT-2) Receptor, Rat	4
CCR2_HUMAN	P41597	CHEMBL4015	C-C Chemokine Receptor Type 2, Human	4
CCR5_HUMAN	P51681	CHEMBL274	C-C Chemokine Receptor Type 5, Human	4
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	4
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	4
NR1I2_HUMAN	O75469	CHEMBL3401	Pregnane X Receptor, Human	4
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	4
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	4
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	4
Z50512	Z50512	CHEMBL369	Cavia Porcellus	4
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	3
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	3
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	3
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	3
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	3
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	3
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	3
NK2R_BOVIN	P05363	CHEMBL4815	Neurokinin 2 Receptor, Bovin	3
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	3
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	3
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	2
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	2
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_CAVPO	P30547	CHEMBL3942	Neurokinin 1 Receptor, Guinea Pig	2
NK2R_CAVPO	Q64077	CHEMBL2647	Neurokinin 2 Receptor, Guinea Pig	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	2
SSR1_HUMAN	P30872	CHEMBL1917	Somatostatin Receptor 1, Human	2
SSR1_MOUSE	P30873	CHEMBL4242	Somatostatin Receptor 1, Mouse	2
SSR2_HUMAN	P30874	CHEMBL1804	Somatostatin Receptor 2, Human	2
SSR2_MOUSE	P30875	CHEMBL3207	Somatostatin Receptor 2, Mouse	2
SSR3_HUMAN	P32745	CHEMBL2028	Somatostatin Receptor 3, Human	2
SSR3_MOUSE	P30935	CHEMBL2238	Somatostatin Receptor 3, Mouse	2
SSR4_HUMAN	P31391	CHEMBL1853	Somatostatin Receptor 4, Human	2
SSR4_MOUSE	P49660	CHEMBL4397	Somatostatin Receptor 4, Mouse	2
SSR5_HUMAN	P35346	CHEMBL1792	Somatostatin Receptor 5, Human	2
SSR5_MOUSE	O08858	CHEMBL2733	Somatostatin Receptor 5, Mouse	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
Z50594	Z50594	CHEMBL375	Mus Musculus	2
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	1
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	1
AGTR1_HUMAN	P30556	CHEMBL227	Angiotensin II Type 1 Receptor, Human	1
CAC1B_HUMAN	Q00975	CHEMBL4478	Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human	1
CAC1G_HUMAN	O43497	CHEMBL4641	Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human	1
CAC1H_HUMAN	O95180	CHEMBL1859	Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human	1
CAC1I_HUMAN	Q9P0X4	CHEMBL5558	Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human	1
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	1
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	1
GHSR_HUMAN	Q92847	CHEMBL4616	Ghrelin Receptor, Human	1
GNRHR_HUMAN	P30968	CHEMBL1855	Gonadotropin-releasing Hormone Receptor, Human	1
GNRHR_RAT	P30969	CHEMBL3066	Gonadotropin-releasing Hormone Receptor, Rat	1
NMBR_HUMAN	P28336	CHEMBL3636	Neuromedin B Receptor, Human	1
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	1
OXYR_HUMAN	P30559	CHEMBL2049	Oxytocin Receptor, Human	1
PTAFR_HUMAN	P25105	CHEMBL250	Platelet Activating Factor Receptor, Human	1
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	1
SC6A3_RAT	P23977	CHEMBL338	Dopamine Transporter, Rat	1
SCN2A_RAT	P04775	CHEMBL3399	Sodium Channel Protein Type II Alpha Subunit, Rat	1
SSR1_RAT	P28646	CHEMBL4652	Somatostatin Receptor 1, Rat	1
SSR2_RAT	P30680	CHEMBL2978	Somatostatin Receptor 2, Rat	1
SSR4_RAT	P30937	CHEMBL4560	Somatostatin Receptor 4, Rat	1
SSR5_RAT	P30938	CHEMBL4318	Somatostatin Receptor 5, Rat	1
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	1
Z80558	Z80558	CHEMBL615020	U11 MG	1
Z80563	Z80563	CHEMBL615025	U-373 MG ( Glioblastoma Cells)	1