UCSF

Neurokinin 2 Receptor, Human (834 Compounds)

Swissprot:
NK2R_HUMAN
Stitch:
NK2R_HUMAN
UniProt:
P21452
ChEMBL:
CHEMBL2327
Reactome:
REACT_18283
REACT_16963
PDB:
TACR2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 834 11 2 6
Binding ≤ 1μM 763 6 2 5
Functional ≤ 10μM 2 0 0 0

Reactome Network (2)

Uniprot Swissprot Chembl Description Number Shared
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 3
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 3
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 3
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 3
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 4
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 4
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 4
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 6
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 517
NK3R_HUMAN P29371 CHEMBL4429 Neurokinin 3 Receptor, Human 110
NMBR_HUMAN P28336 CHEMBL3636 Neuromedin B Receptor, Human 1
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 1
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 1
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 2

Tachykinin receptors bind tachykinins

Uniprot Swissprot Chembl Description Number Shared
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 517
NK3R_HUMAN P29371 CHEMBL4429 Neurokinin 3 Receptor, Human 110
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NK2R_BOVIN P05363 CHEMBL4815 Neurokinin 2 Receptor, Bovin 5 0 0 1
NK2R_CAVPO Q64077 CHEMBL2647 Neurokinin 2 Receptor, Guinea Pig 14 0 0 0
NK2R_MOUSE P30549 CHEMBL2813 Neurokinin 2 Receptor, Mouse 27 0 0 0
NK2R_RAT P16610 CHEMBL4554 Neurokinin 2 Receptor, Rat 36 1 0 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 517
NK3R_HUMAN P29371 CHEMBL4429 Neurokinin 3 Receptor, Human 110
NK2R_RAT P16610 CHEMBL4554 Neurokinin 2 Receptor, Rat 18
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 17
NK3R_RAT P16177 CHEMBL3154 Neurokinin 3 Receptor, Rat 9
NK3R_CAVPO P30098 CHEMBL3799 Neurokinin 3 Receptor, Guinea Pig 8
NK1R_RAT P14600 CHEMBL4027 Neurokinin 1 Receptor, Rat 7
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 6
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 5
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 5
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 5
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 4
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 4
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 4
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 4
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 4
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 4
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 4
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 4
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 3
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 3
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 3
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 3
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 3
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 3
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 3
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 3
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 3
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 3
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 3
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 3
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 3
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 3
NK2R_BOVIN P05363 CHEMBL4815 Neurokinin 2 Receptor, Bovin 3
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 3
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 3
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 2
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_CAVPO P30547 CHEMBL3942 Neurokinin 1 Receptor, Guinea Pig 2
NK2R_CAVPO Q64077 CHEMBL2647 Neurokinin 2 Receptor, Guinea Pig 2
NK2R_MOUSE P30549 CHEMBL2813 Neurokinin 2 Receptor, Mouse 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z50594 Z50594 CHEMBL375 Mus Musculus 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 1
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 1
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 1
CRFR1_HUMAN P34998 CHEMBL1800 Corticotropin Releasing Factor Receptor 1, Human 1
CRFR1_RAT P35353 CHEMBL4649 Corticotropin Releasing Factor Receptor 1, Rat 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 1
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 1
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
NMBR_HUMAN P28336 CHEMBL3636 Neuromedin B Receptor, Human 1
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 1
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 1
TSPOB_HUMAN B1AH88 CHEMBL5139 Peripheral-type Benzodiazepine Receptor, Human 1