ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (834)
Reactome (2)
Related By:
Pathway (21)
Organism (4)
Gene (0)
Org. Clust. (0)
ChEMBL (94)
Rings (9)

Neurokinin 2 Receptor, Human (834 Compounds)

Swissprot:: NK2R_HUMAN
Stitch:: NK2R_HUMAN
UniProt:: P21452
ChEMBL:: CHEMBL2327
Reactome:: REACT_18283; REACT_16963
PDB:: TACR2

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	834	11	2	6
Binding ≤ 1μM	763	6	2	5
Functional ≤ 10μM	2	0	0	0

Reactome ID	Description	Species
REACT_18283	G alpha (q) signalling events	Homo sapiens
REACT_16963	Tachykinin receptors bind tachykinins	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	3
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	3
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	3
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	3
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	4
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	4
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	4
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GNRHR_HUMAN	P30968	CHEMBL1855	Gonadotropin-releasing Hormone Receptor, Human	1
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	6
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	517
NK3R_HUMAN	P29371	CHEMBL4429	Neurokinin 3 Receptor, Human	110
NMBR_HUMAN	P28336	CHEMBL3636	Neuromedin B Receptor, Human	1
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	1
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	1
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	2

Tachykinin receptors bind tachykinins

Uniprot	Swissprot	Chembl	Description	Number Shared
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	517
NK3R_HUMAN	P29371	CHEMBL4429	Neurokinin 3 Receptor, Human	110

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	In Man
NK2R_BOVIN	P05363	CHEMBL4815	Neurokinin 2 Receptor, Bovin	5	0	1
NK2R_CAVPO	Q64077	CHEMBL2647	Neurokinin 2 Receptor, Guinea Pig	14	0	0
NK2R_MOUSE	P30549	CHEMBL2813	Neurokinin 2 Receptor, Mouse	27	0	0
NK2R_RAT	P16610	CHEMBL4554	Neurokinin 2 Receptor, Rat	36	1	2

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	517
NK3R_HUMAN	P29371	CHEMBL4429	Neurokinin 3 Receptor, Human	110
NK2R_RAT	P16610	CHEMBL4554	Neurokinin 2 Receptor, Rat	18
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	17
NK3R_RAT	P16177	CHEMBL3154	Neurokinin 3 Receptor, Rat	9
NK3R_CAVPO	P30098	CHEMBL3799	Neurokinin 3 Receptor, Guinea Pig	8
NK1R_RAT	P14600	CHEMBL4027	Neurokinin 1 Receptor, Rat	7
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	6
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	5
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	5
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	5
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	4
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	4
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	4
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	4
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	4
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	4
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	4
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	4
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	3
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	3
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	3
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	3
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	3
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	3
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	3
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	3
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	3
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	3
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	3
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	3
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	3
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	3
NK2R_BOVIN	P05363	CHEMBL4815	Neurokinin 2 Receptor, Bovin	3
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	3
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	3
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CCR5_HUMAN	P51681	CHEMBL274	C-C Chemokine Receptor Type 5, Human	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_CAVPO	P30547	CHEMBL3942	Neurokinin 1 Receptor, Guinea Pig	2
NK2R_CAVPO	Q64077	CHEMBL2647	Neurokinin 2 Receptor, Guinea Pig	2
NK2R_MOUSE	P30549	CHEMBL2813	Neurokinin 2 Receptor, Mouse	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
Z50594	Z50594	CHEMBL375	Mus Musculus	2
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	2
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	1
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	1
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	1
CAC1C_HUMAN	Q13936	CHEMBL1940	Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human	1
CAC1D_HUMAN	Q01668	CHEMBL4138	Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human	1
CAC1F_HUMAN	O60840	CHEMBL5593	Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human	1
CAC1S_HUMAN	Q13698	CHEMBL3805	Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human	1
CCR1_HUMAN	P32246	CHEMBL2413	C-C Chemokine Receptor Type 1, Human	1
CRFR1_HUMAN	P34998	CHEMBL1800	Corticotropin Releasing Factor Receptor 1, Human	1
CRFR1_RAT	P35353	CHEMBL4649	Corticotropin Releasing Factor Receptor 1, Rat	1
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1
GNRHR_HUMAN	P30968	CHEMBL1855	Gonadotropin-releasing Hormone Receptor, Human	1
GNRHR_RAT	P30969	CHEMBL3066	Gonadotropin-releasing Hormone Receptor, Rat	1
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	1
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	1
HRH4_RAT	Q91ZY1	CHEMBL4468	Histamine H4 Receptor, Rat	1
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
NMBR_HUMAN	P28336	CHEMBL3636	Neuromedin B Receptor, Human	1
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	1
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	1
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	1
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	1
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	1
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	1
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	1
TSPOB_HUMAN	B1AH88	CHEMBL5139	Peripheral-type Benzodiazepine Receptor, Human	1