ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (470)
Reactome (2)
Related By:
Pathway (21)
Organism (2)
Gene (3)
Org. Clust. (3)
ChEMBL (108)
Rings (30)

Histamine H4 Receptor, Human (470 Compounds)

Swissprot:: HRH4_HUMAN
Stitch:: HRH4_HUMAN
UniProt:: Q9H3N8
ChEMBL:: CHEMBL3759
Reactome:: REACT_19231; REACT_16903
PDB:: HRH4

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	470	55	13	4
Binding ≤ 1μM	407	38	12	3
Functional ≤ 10μM	34	4	2	1

Reactome ID	Description	Species
REACT_19231	G alpha (i) signalling events	Homo sapiens
REACT_16903	Histamine receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	4
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	3
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	2
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	3
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	1
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	3
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	3
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	7
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	3
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	7
CCR1_HUMAN	P32246	CHEMBL2413	C-C Chemokine Receptor Type 1, Human	1
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	3
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	3
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	3
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	150
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2

Histamine receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	27
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	31
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	150

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
HRH4_MOUSE	Q91ZY2	CHEMBL5657	Histamine H4 Receptor, Mouse	8	1	1	1
HRH4_RAT	Q91ZY1	CHEMBL4468	Histamine H4 Receptor, Rat	55	10	4	5

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	529	66	50	47
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	144	13	10	5
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2,395	54	18	9

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
HRH4-1-E	Histamine H4 Receptor (cluster #1 Of 4), Eukaryotic	379	32	4	5
HRH4-2-E	Histamine H4 Receptor (cluster #2 Of 4), Eukaryotic	112	23	10	2
HRH4-3-E	Histamine H4 Receptor (cluster #3 Of 4), Eukaryotic	2	1	0	0
HRH4-4-E	Histamine H4 Receptor (cluster #4 Of 4), Eukaryotic	2	2	1	0

Uniprot	Swissprot	Chembl	Description	Number Shared
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	149
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	33
HRH4_RAT	Q91ZY1	CHEMBL4468	Histamine H4 Receptor, Rat	33
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	31
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	27
HRH2_CAVPO	P47747	CHEMBL2882	Histamine H2 Receptor, Guinea Pig	8
HRH4_MOUSE	Q91ZY2	CHEMBL5657	Histamine H4 Receptor, Mouse	8
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	7
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	7
HRH3_MOUSE	P58406	CHEMBL3263	Histamine H3 Receptor, Mouse	5
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	4
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	4
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	4
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	4
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	3
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	3
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	3
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	3
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	3
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	3
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	3
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	3
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	3
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	3
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	3
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	3
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	3
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	3
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	3
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	3
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	3
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	3
HRH3_CAVPO	Q9JI35	CHEMBL5076	Histamine H3 Receptor, Guinea Pig	3
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	3
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	3
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	2
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	2
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	2
Z100488	Z100488	CHEMBL612574	Mast Cells (Bone-marrow Mast Cells)	2
Z100489	Z100489	CHEMBL614636	Eosinophils (Eosinophils)	2
5HT1A_MOUSE	Q64264	CHEMBL3737	Serotonin 1a (5-HT1a) Receptor, Mouse	1
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	1
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	1
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	1
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	1
5HT2A_BOVIN	Q75Z89	CHEMBL3446	Serotonin 2a (5-HT2a) Receptor, Bovin	1
5HT2A_MOUSE	P35363	CHEMBL5377	Serotonin 2a (5-HT2a) Receptor, Mouse	1
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	1
5HT2B_MOUSE	Q02152	CHEMBL2583	Serotonin 2b (5-HT2b) Receptor, Mouse	1
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	1
5HT2C_MOUSE	P34968	CHEMBL3006	Serotonin 2c (5-HT2c) Receptor, Mouse	1
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	1
5HT3A_MOUSE	P23979	CHEMBL4972	Serotonin 3a (5-HT3a) Receptor, Mouse	1
5HT3A_RAT	P35563	CHEMBL2411	Serotonin 3a (5-HT3a) Receptor, Rat	1
5HT3B_RAT	Q9JJ16	CHEMBL3458	Serotonin 3b (5-HT3b) Receptor, Rat	1
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	1
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	1
ACES_RAT	P37136	CHEMBL3199	Acetylcholinesterase, Rat	1
ACM1_RAT	P08482	CHEMBL276	Muscarinic Acetylcholine Receptor M1, Rat	1
ACM2_RAT	P10980	CHEMBL309	Muscarinic Acetylcholine Receptor M2, Rat	1
ACM3_RAT	P08483	CHEMBL320	Muscarinic Acetylcholine Receptor M3, Rat	1
ACM4_RAT	P08485	CHEMBL317	Muscarinic Acetylcholine Receptor M4, Rat	1
ADA1A_BOVIN	P18130	CHEMBL4892	Alpha-1a Adrenergic Receptor, Bovin	1
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	1
ADA1B_RAT	P15823	CHEMBL315	Alpha-1b Adrenergic Receptor, Rat	1
ADA1D_RAT	P23944	CHEMBL326	Alpha-1d Adrenergic Receptor, Rat	1
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	1
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	1
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	1
CCR1_HUMAN	P32246	CHEMBL2413	C-C Chemokine Receptor Type 1, Human	1
DRD1_BOVIN	Q95136	CHEMBL2967	Dopamine D1 Receptor, Bovin	1
DRD1_PIG	P50130	CHEMBL5067	Dopamine D1 Receptor, Pig	1
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	1
DRD2_BOVIN	P20288	CHEMBL3998	Dopamine D2 Receptor, Bovin	1
DRD2_CHLAE	P52702	CHEMBL5456	Dopamine D2 Receptor, Chlae	1
DRD2_MOUSE	P61168	CHEMBL3427	Dopamine D2 Receptor, Mouse	1
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	1
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	1
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	1
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	1
HNMT_RAT	Q01984	CHEMBL3241	Histamine N-methyltransferase, Rat	1
HRH1_RAT	P31390	CHEMBL4701	Histamine H1 Receptor, Rat	1
HRH2_RAT	P25102	CHEMBL4654	Histamine H2 Receptor, Rat	1
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	1
NMD3A_HUMAN	Q8TCU5	CHEMBL4787	Glutamate [NMDA] Receptor Subunit 3A, Human	1
NMD3B_HUMAN	O60391	CHEMBL2913	Glutamate [NMDA] Receptor Subunit 3B, Human	1
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	1
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	1
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	1
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	1
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	1
Q63380_RAT	Q63380	CHEMBL6184	Transporter, Rat	1
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	1
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	1
Z104303	Z104303	CHEMBL1907609	Muscarinic Acetylcholine Receptor	1
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	1
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	1
Z50512	Z50512	CHEMBL369	Cavia Porcellus	1
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	1