ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (2,395)
Reactome (2)
Related By:
Pathway (27)
Organism (3)
Gene (3)
Org. Clust. (2)
ChEMBL (112)
Rings (50)

Histamine H3 Receptor, Human (2,395 Compounds)

Swissprot:: HRH3_HUMAN
Stitch:: HRH3_HUMAN
UniProt:: Q9Y5N1
ChEMBL:: CHEMBL264
Reactome:: REACT_19231; REACT_16903
PDB:: HRH3

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	2,395	54	18	9
Binding ≤ 1μM	2,264	45	14	7
Functional ≤ 10μM	305	21	5	2

Reactome ID	Description	Species
REACT_19231	G alpha (i) signalling events	Homo sapiens
REACT_16903	Histamine receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	7
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	5
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	3
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	2
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	4
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	3
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	6
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	5
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	11
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	6
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	10
CCR1_HUMAN	P32246	CHEMBL2413	C-C Chemokine Receptor Type 1, Human	1
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	12
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	13
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	5
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	150
MCHR1_HUMAN	Q99705	CHEMBL344	Melanin-concentrating Hormone Receptor 1, Human	22
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	5
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	6

Histamine receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	45
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	36
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	150

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
HRH3_CAVPO	Q9JI35	CHEMBL5076	Histamine H3 Receptor, Guinea Pig	125	5	8	0
HRH3_MOUSE	P58406	CHEMBL3263	Histamine H3 Receptor, Mouse	23	5	5	1
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	1,023	26	14	8

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	529	66	50	47
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	144	13	10	5
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	470	55	13	4

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
HRH3-1-E	Histamine H3 Receptor (cluster #1 Of 3), Eukaryotic	920	32	16	7
HRH3-2-E	Histamine H3 Receptor (cluster #2 Of 3), Eukaryotic	1,837	24	11	6
HRH3-3-E	Histamine H3 Receptor (cluster #3 Of 3), Eukaryotic	142	9	2	2

Uniprot	Swissprot	Chembl	Description	Number Shared
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	693
SC6A4_RAT	P31652	CHEMBL313	Serotonin Transporter, Rat	323
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	298
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	291
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	149
HRH3_MOUSE	P58406	CHEMBL3263	Histamine H3 Receptor, Mouse	57
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	44
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	36
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	33
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	33
HNMT_RAT	Q01984	CHEMBL3241	Histamine N-methyltransferase, Rat	32
MCHR1_HUMAN	Q99705	CHEMBL344	Melanin-concentrating Hormone Receptor 1, Human	22
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	21
ACES_RAT	P37136	CHEMBL3199	Acetylcholinesterase, Rat	16
HRH1_RAT	P31390	CHEMBL4701	Histamine H1 Receptor, Rat	16
HRH4_RAT	Q91ZY1	CHEMBL4468	Histamine H4 Receptor, Rat	15
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	12
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	12
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	12
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	11
HRH3_CAVPO	Q9JI35	CHEMBL5076	Histamine H3 Receptor, Guinea Pig	11
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	10
Q63380_RAT	Q63380	CHEMBL6184	Transporter, Rat	10
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	9
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	8
HRH4_MOUSE	Q91ZY2	CHEMBL5657	Histamine H4 Receptor, Mouse	8
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	6
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	6
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	6
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	6
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	6
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	5
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	5
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	5
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	5
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	5
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	5
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	5
HRH2_CAVPO	P47747	CHEMBL2882	Histamine H2 Receptor, Guinea Pig	5
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	5
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	4
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	4
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	4
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	4
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	4
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	4
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	4
CAC1C_RABIT	P15381	CHEMBL2830	Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rabit	4
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	4
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	3
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	3
ACES_MOUSE	P21836	CHEMBL3198	Acetylcholinesterase, Mouse	3
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	3
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	3
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	2
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	2
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	2
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	2
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	2
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	2
ACES_BOVIN	P23795	CHEMBL4768	Acetylcholinesterase, Bovin	2
ACES_ELEEL	O42275	CHEMBL4078	Acetylcholinesterase, Eleel	2
ACES_TORCA	P04058	CHEMBL4780	Acetylcholinesterase, Torca	2
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	2
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	2
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	2
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CHLE_HORSE	P81908	CHEMBL5763	Cholinesterase, Horse	2
CHLE_HUMAN	P06276	CHEMBL1914	Butyrylcholinesterase, Human	2
CLAT_RAT	P32738	CHEMBL3945	Choline Acetylase, Rat	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	2
Q9JKC1_RAT	Q9JKC1	CHEMBL3403	Butyrylcholinesterase, Rat	2
Q9N1N9_HORSE	Q9N1N9	CHEMBL5077	Butyrylcholinesterase, Horse	2
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
SC6A2_MOUSE	O55192	CHEMBL2370	Norepinephrine Transporter, Mouse	2
SC6A3_MOUSE	Q61327	CHEMBL2799	Dopamine Transporter, Mouse	2
SC6A3_RAT	P23977	CHEMBL338	Dopamine Transporter, Rat	2
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	2
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	2
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	2
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	1
5HT3B_HUMAN	O95264	CHEMBL3895	Serotonin 3b (5-HT3b) Receptor, Human	1
5HT3C_HUMAN	Q8WXA8	CHEMBL4795	Serotonin 3c (5-HT3c) Receptor, Human	1
5HT3D_HUMAN	Q70Z44	CHEMBL4673	Serotonin 3d (5-HT3d) Receptor, Human	1
5HT3E_HUMAN	A5X5Y0	CHEMBL3812	Serotonin 3e (5-HT3e) Receptor, Human	1
CCR1_HUMAN	P32246	CHEMBL2413	C-C Chemokine Receptor Type 1, Human	1
HRH1_CAVPO	P31389	CHEMBL3943	Histamine H1 Receptor, Guinea Pig	1
Q865E1_MACMU	Q865E1	CHEMBL5299	Histamine Receptor H3, Macmu	1
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	1
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	1
Z102275	Z102275	CHEMBL613575	Hypothalamus	1
Z104288	Z104288	CHEMBL1907594	Neuronal Acetylcholine Receptor; Alpha3/beta4	1
Z50512	Z50512	CHEMBL369	Cavia Porcellus	1
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	1