ZINC 12

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Names
Compounds (2,290)
Reactome (2)
Related By:
Pathway (20)
Organism (2)
Gene (0)
Org. Clust. (0)
ChEMBL (74)
Rings (18)

Melanocortin Receptor 4, Human (2,290 Compounds)

Swissprot:: MC4R_HUMAN
Stitch:: MC4R_HUMAN
UniProt:: P32245
ChEMBL:: CHEMBL259
Reactome:: REACT_19327; REACT_14819
PDB:: 2IQP (DOCK); 2IQR (DOCK); 2IQS (DOCK); 2IQU (DOCK); 2IQV (DOCK); 2IQW (DOCK); MC4R

Compound Summary

Annotation Type	Substances	Purchasable
Binding ≤ 10μM	2,290	5
Binding ≤ 1μM	1,923	3
Functional ≤ 10μM	756	0

Reactome ID	Description	Species
REACT_19327	G alpha (s) signalling events	Homo sapiens
REACT_14819	Peptide ligand-binding receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	2
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	2
MC3R_HUMAN	P41968	CHEMBL4644	Melanocortin Receptor 3, Human	408
MC5R_HUMAN	P33032	CHEMBL4608	Melanocortin Receptor 5, Human	345
MSHR_HUMAN	Q01726	CHEMBL3795	Melanocortin Receptor 1, Human	274

Peptide ligand-binding receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GHSR_HUMAN	Q92847	CHEMBL4616	Ghrelin Receptor, Human	7
MC3R_HUMAN	P41968	CHEMBL4644	Melanocortin Receptor 3, Human	408
MC5R_HUMAN	P33032	CHEMBL4608	Melanocortin Receptor 5, Human	345
MSHR_HUMAN	Q01726	CHEMBL3795	Melanocortin Receptor 1, Human	274
NMUR1_HUMAN	Q9HB89	CHEMBL1075178	Neuromedin-U Receptor 1, Human	4
NMUR2_HUMAN	Q9GZQ4	CHEMBL1075144	Neuromedin-U Receptor 2, Human	4
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
MC4R_MOUSE	P56450	CHEMBL3719	Melanocortin Receptor 4, Mouse	39	0	0	0
MC4R_RAT	P70596	CHEMBL2700	Melanocortin Receptor 4, Rat	9	0	0	0

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
MC3R_HUMAN	P41968	CHEMBL4644	Melanocortin Receptor 3, Human	407
MC5R_HUMAN	P33032	CHEMBL4608	Melanocortin Receptor 5, Human	345
MSHR_HUMAN	Q01726	CHEMBL3795	Melanocortin Receptor 1, Human	273
MSHR_MOUSE	Q01727	CHEMBL4077	Melanocortin Receptor 1, Mouse	127
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	30
SC6A4_RAT	P31652	CHEMBL313	Serotonin Transporter, Rat	30
MC4R_MOUSE	P56450	CHEMBL3719	Melanocortin Receptor 4, Mouse	15
Z81011	Z81011	CHEMBL614840	Human Cell Lines	15
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	14
MC4R_RAT	P70596	CHEMBL2700	Melanocortin Receptor 4, Rat	12
Z50594	Z50594	CHEMBL375	Mus Musculus	10
MTR1B_HUMAN	P49286	CHEMBL1946	Melatonin Receptor 1B, Human	9
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	8
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	8
Z80936	Z80936	CHEMBL614818	HEK293 (Embryonic Kidney Fibroblasts)	8
GHSR_HUMAN	Q92847	CHEMBL4616	Ghrelin Receptor, Human	7
MC3R_MOUSE	P33033	CHEMBL4774	Melanocortin Receptor 3, Mouse	6
MC3R_RAT	P32244	CHEMBL4023	Melanocortin Receptor 3, Rat	4
NMUR1_HUMAN	Q9HB89	CHEMBL1075178	Neuromedin-U Receptor 1, Human	4
NMUR2_HUMAN	Q9GZQ4	CHEMBL1075144	Neuromedin-U Receptor 2, Human	4
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	2
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	2
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	2
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	2
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	2
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	2
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	2
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	2
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	2
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC5R_MOUSE	P41149	CHEMBL4489	Melanocortin Receptor 5, Mouse	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	2
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	2
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
MC5R_RAT	P35345	CHEMBL2701	Melanocortin Receptor 5, Rat	1
Z80236	Z80236	CHEMBL614332	MCR (Frog Skin Melanocyte Cells)	1