UCSF

Serotonin 4 (5-HT4) Receptor, Human (258 Compounds)

Swissprot:
5HT4R_HUMAN
Stitch:
5HT4R_HUMAN
UniProt:
Q13639
ChEMBL:
CHEMBL1875
Reactome:
REACT_19327
REACT_17064
PDB:
HTR4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 258 31 13 12
Binding ≤ 1μM 232 28 12 12
Functional ≤ 10μM 71 15 5 6

Reactome Network (2)

Reactome ID Description Species
REACT_19327 G alpha (s) signalling events Homo sapiens
REACT_17064 Serotonin receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 14
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 15
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 4
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 6
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 7
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 3
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 4
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2

Serotonin receptors

Uniprot Swissprot Chembl Description Number Shared
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 18
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 18
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 19
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 13
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 11
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 23
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 21
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 24
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 10
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 14
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 15
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 59 7 3 3
5HT4R_MOUSE P97288 CHEMBL2183 Serotonin 4 (5-HT4) Receptor, Mouse 3 0 0 0
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 144 26 16 16

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 35
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 23
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 23
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 22
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 22
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 20
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 18
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 17
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 17
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 14
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 14
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 12
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 12
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 12
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 11
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 10
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) Receptor, Human 10
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 10
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 10
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 10
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 9
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) Receptor, Human 9
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) Receptor, Human 9
5HT3E_HUMAN A5X5Y0 CHEMBL3812 Serotonin 3e (5-HT3e) Receptor, Human 9
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 9
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 8
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 8
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 8
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 7
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 7
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 7
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 7
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 7
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 6
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 6
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 6
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 6
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 6
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 6
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 6
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 6
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 5
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 5
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 5
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 5
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 5
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 5
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 5
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 5
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 5
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 5
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 4
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 4
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 4
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 4
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 4
Z50512 Z50512 CHEMBL369 Cavia Porcellus 4
5HT3A_MOUSE P23979 CHEMBL4972 Serotonin 3a (5-HT3a) Receptor, Mouse 3
5HT3B_MOUSE Q9JHJ5 CHEMBL3781 Serotonin 3b (5-HT3b) Receptor, Mouse 3
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 3
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 3
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 3
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 3
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 3
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 3
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 3
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 3
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 3
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 3
5HT1A_MOUSE Q64264 CHEMBL3737 Serotonin 1a (5-HT1a) Receptor, Mouse 2
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 2
5HT3A_CAVPO O70212 CHEMBL3666 Serotonin 3a (5-HT3a) Receptor, Guinea Pig 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 2
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH3_CAVPO Q9JI35 CHEMBL5076 Histamine H3 Receptor, Guinea Pig 2
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 2
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 1
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 1
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 1
5HT4R_MOUSE P97288 CHEMBL2183 Serotonin 4 (5-HT4) Receptor, Mouse 1
5HT5A_MOUSE P30966 CHEMBL3597 Serotonin 5a (5-HT5a) Receptor, Mouse 1
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 1
ACES_TORCA P04058 CHEMBL4780 Acetylcholinesterase, Torca 1
ACHA7_RAT Q05941 CHEMBL4980 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat 1
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1I_HUMAN Q9P0X4 CHEMBL5558 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human 1
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 1
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 1
GALR3_HUMAN O60755 CHEMBL2731 Galanin Receptor 3, Human 1
HRH1_CAVPO P31389 CHEMBL3943 Histamine H1 Receptor, Guinea Pig 1
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 1
V1BR_RAT P48974 CHEMBL2659 Vasopressin V1b Receptor, Rat 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50588 Z50588 CHEMBL373 Canis Familiaris 1
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1
Z80334 Z80334 CHEMBL613828 NG108-15 (Neuroblastoma-glioma Hybrid Cells) 1