UCSF

Cannabinoid CB1 Receptor, Human (2,791 Compounds)

Swissprot:
CNR1_HUMAN
Stitch:
CNR1_HUMAN
UniProt:
P21554
ChEMBL:
CHEMBL218
Reactome:
REACT_14828
REACT_19231
PDB:
1LVQ (DOCK)
1LVR (DOCK)
2B0Y (DOCK)
2KOE (DOCK)
CNR1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,791 161 19 12
Binding ≤ 1μM 2,282 123 16 11
Functional ≤ 10μM 409 38 5 4

Reactome Network (2)

Reactome ID Description Species
REACT_14828 Class A/1 (Rhodopsin-like receptors) Homo sapiens
REACT_19231 G alpha (i) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 1694
GPR55_HUMAN Q9Y2T6 CHEMBL1075322 G-protein Coupled Receptor 55, Human 1
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 5
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 3
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 3
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
BKRB1_HUMAN P46663 CHEMBL4308 Bradykinin B1 Receptor, Human 1
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 1694
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 3
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 3
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
GPR55_HUMAN Q9Y2T6 CHEMBL1075322 G-protein Coupled Receptor 55, Human 1
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 6
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 6
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CNR1_MOUSE P47746 CHEMBL3037 Cannabinoid CB1 Receptor, Mouse 103 19 5 3
CNR1_RAT P20272 CHEMBL3571 Cannabinoid CB1 Receptor, Rat 1,424 89 26 10
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 2,540 143 15 10
CNRG_HUMAN P18545 CHEMBL2415 Phosphodiesterase 6G, Human 33 5 5 5

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
CNR1-1-E Cannabinoid CB1 Receptor (cluster #1 Of 5), Eukaryotic 3,810 186 15 14
CNR1-2-E Cannabinoid CB1 Receptor (cluster #2 Of 5), Eukaryotic 68 14 9 3
CNR1-3-E Cannabinoid CB1 Receptor (cluster #3 Of 5), Eukaryotic 290 38 12 1
CNR1-4-E Cannabinoid CB1 Receptor (cluster #4 Of 5), Eukaryotic 3 0 0 0
CNR1-5-E Cannabinoid CB1 Receptor (cluster #5 Of 5), Eukaryotic 18 3 1 1
Uniprot Swissprot Chembl Description Number Shared
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 1669
CNR1_RAT P20272 CHEMBL3571 Cannabinoid CB1 Receptor, Rat 176
CNR2_MOUSE P47936 CHEMBL5373 Cannabinoid CB2 Receptor, Mouse 86
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 55
CNR2_RAT Q9QZN9 CHEMBL2470 Cannabinoid CB2 Receptor, Rat 52
CNR1_MOUSE P47746 CHEMBL3037 Cannabinoid CB1 Receptor, Mouse 22
DGLA_HUMAN Q9Y4D2 CHEMBL5545 Sn1-specific Diacylglycerol Lipase Alpha, Human 12
TSPO_RAT P16257 CHEMBL4552 Peripheral-type Benzodiazepine Receptor, Rat 10
FAAH1_RAT P97612 CHEMBL3229 Anandamide Amidohydrolase, Rat 8
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 6
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 6
FAAH1_HUMAN O00519 CHEMBL2243 Anandamide Amidohydrolase, Human 6
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 6
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 6
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 5
Z50594 Z50594 CHEMBL375 Mus Musculus 5
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 4
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 4
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 3
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 3
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 3
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 3
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 3
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 3
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 3
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 3
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 3
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 3
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 3
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 3
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 3
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 3
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 2
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z50512 Z50512 CHEMBL369 Cavia Porcellus 2
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
ABD12_HUMAN Q8N2K0 CHEMBL5516 Monoacylglycerol Lipase ABHD12, Human 1
ABHGA_HUMAN O95870 CHEMBL6168 Protein BAT5, Human 1
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 1
BKRB1_HUMAN P46663 CHEMBL4308 Bradykinin B1 Receptor, Human 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 1
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 1
DGLB_HUMAN Q8NCG7 CHEMBL5521 Sn1-specific Diacylglycerol Lipase Beta, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 1
GPR55_HUMAN Q9Y2T6 CHEMBL1075322 G-protein Coupled Receptor 55, Human 1
LIPP_PIG P00591 CHEMBL1687677 Pancreatic Triacylglycerol Lipase, Pig 1
NR1I2_HUMAN O75469 CHEMBL3401 Pregnane X Receptor, Human 1
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
PAFA_HUMAN Q13093 CHEMBL3514 LDL-associated Phospholipase A2, Human 1
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 1
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN5A_HUMAN Q14524 CHEMBL1980 Sodium Channel Protein Type V Alpha Subunit, Human 1
SCN9A_HUMAN Q15858 CHEMBL4296 Sodium Channel Protein Type IX Alpha Subunit, Human 1
SCNAA_HUMAN Q9Y5Y9 CHEMBL5451 Sodium Channel Protein Type X Alpha Subunit, Human 1
SCNAA_MOUSE Q6QIY3 CHEMBL5158 Sodium Channel Protein Type 10 Subunit Alpha, Mouse 1
SCNAA_RAT Q62968 CHEMBL4017 Sodium Channel Protein Type X Alpha Subunit, Rat 1
TRPV1_HUMAN Q8NER1 CHEMBL4794 Vanilloid Receptor, Human 1
TRPV1_RAT O35433 CHEMBL5102 Vanilloid Receptor, Rat 1
TSPOA_HUMAN P30536 CHEMBL5742 Translocator Protein, Human 1
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 1

Most Common Rings