UCSF
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Identity 99% 90% 80% 70% Substructure

Thiophene

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Ring Information

Rings Ring Systems Atoms Carbons Nitrogens Oxygens Sulfurs
1 1 5 4 0 0 1

Subset Information

Substances Natural Purchasable Annotated BB In Man Last Updated
View 182 315,528 963 22,103 25 2012-03-06

Most Common Targets

Name (Uniprot) Swissprot ChEMBL Description Size Browse Download (Annotations)
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 107 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 95 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 92 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 88 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 76 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 74 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 74 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 70 Annotations Catalogs SMILES SDF Mol2 Flexibase
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 68 Annotations Catalogs SMILES SDF Mol2 Flexibase
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 63 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM1_HUMAN Q13255 CHEMBL3772 Metabotropic Glutamate Receptor 1, Human 51 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM1_RAT P23385 CHEMBL4477 Metabotropic Glutamate Receptor 1, Rat 47 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM1_RAT P23385 CHEMBL4477 Metabotropic Glutamate Receptor 1, Rat 46 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 45 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 44 Annotations Catalogs SMILES SDF Mol2 Flexibase
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 39 Annotations Catalogs SMILES SDF Mol2 Flexibase
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 38 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 36 Annotations Catalogs SMILES SDF Mol2 Flexibase
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 34 Annotations Catalogs SMILES SDF Mol2 Flexibase
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 33 Annotations Catalogs SMILES SDF Mol2 Flexibase
C1S_HUMAN P09871 CHEMBL3913 Complement C1s, Human 32 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 32 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 28 Annotations Catalogs SMILES SDF Mol2 Flexibase
C1S_HUMAN P09871 CHEMBL3913 Complement C1s, Human 27 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM5_HUMAN P41594 CHEMBL3227 Metabotropic Glutamate Receptor 5, Human 27 Annotations Catalogs SMILES SDF Mol2 Flexibase
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 26 Annotations Catalogs SMILES SDF Mol2 Flexibase
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 25 Annotations Catalogs SMILES SDF Mol2 Flexibase
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 22 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACACA_HUMAN Q13085 CHEMBL3351 Acetyl-CoA Carboxylase 1, Human 20 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACACA_HUMAN Q13085 CHEMBL3351 Acetyl-CoA Carboxylase 1, Human 20 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 20 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 20 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 20 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 20 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 20 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACES_ELEEL O42275 CHEMBL4078 Acetylcholinesterase, Eleel 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 15 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 15 Annotations Catalogs SMILES SDF Mol2 Flexibase
PE2R4_RAT P43114 CHEMBL4086 Prostanoid EP4 Receptor, Rat 15 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 14 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
PE2R2_RAT Q62928 CHEMBL4909 Prostanoid EP2 Receptor, Rat 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
PE2R4_RAT P43114 CHEMBL4086 Prostanoid EP4 Receptor, Rat 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
PE2R4_RAT P43114 CHEMBL4086 Prostanoid EP4 Receptor, Rat 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
MCHR1_HUMAN Q99705 CHEMBL344 Melanin-concentrating Hormone Receptor 1, Human 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
MCHR1_HUMAN Q99705 CHEMBL344 Melanin-concentrating Hormone Receptor 1, Human 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80008 Z80008 CHEMBL612565 5637 (Epithelial Bladder Carcinoma Cells) 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80711 Z80711 CHEMBL613829 NCI/ADR-RES (Breast Carcinoma Cells) 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
DPOL_HCMVA P08546 CHEMBL3414 Human Herpesvirus 5 DNA Polymerase, Hcmva 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
PE2R2_RAT Q62928 CHEMBL4909 Prostanoid EP2 Receptor, Rat 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC5A2_HUMAN P31639 CHEMBL3884 Sodium/glucose Cotransporter 2, Human 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC5A2_HUMAN P31639 CHEMBL3884 Sodium/glucose Cotransporter 2, Human 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
CP2D6_HUMAN P10635 CHEMBL289 Cytochrome P450 2D6, Human 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
GPBAR_HUMAN Q8TDU6 CHEMBL5409 G-protein Coupled Bile Acid Receptor 1, Human 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
Q8JXU8_9HEPC Q8JXU8 CHEMBL5375 Hepatitis C Virus NS5B RNA-dependent RNA Polymerase, 9hepc 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80933 Z80933 CHEMBL613869 HEY (Ovarian Carcinoma Cells) 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
CEL_BOVIN P30122 CHEMBL2988 Cholesterol Esterase, Bovin 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACES_ELEEL O42275 CHEMBL4078 Acetylcholinesterase, Eleel 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 7 Annotations Catalogs SMILES SDF Mol2 Flexibase