UCSF

Caspase-3, Human (987 Compounds)

Swissprot:
CASP3_HUMAN
Stitch:
CASP3_HUMAN
UniProt:
P42574
ChEMBL:
CHEMBL2334
Reactome:
REACT_607
REACT_13462
REACT_13579
REACT_107
REACT_13541
REACT_118572
REACT_13526
REACT_22128
REACT_118607
REACT_2190
REACT_1767
REACT_13532
PDB:
1CP3 (DOCK)
1GFW (DOCK)
1I3O (DOCK)
1NME (DOCK)
1NMQ (DOCK)
1NMS (DOCK)
1PAU (DOCK)
1QX3 (DOCK)
1RE1 (DOCK)
1RHJ (DOCK)
1RHK (DOCK)
1RHM (DOCK)
1RHQ (DOCK)
1RHR (DOCK)
1RHU (DOCK)
2C1E (DOCK)
2C2K (DOCK)
2C2M (DOCK)
2C2O (DOCK)
2CDR (DOCK)
2CJX (DOCK)
2CJY (DOCK)
2CNK (DOCK)
2CNL (DOCK)
2CNN (DOCK)
2CNO (DOCK)
2DKO (DOCK)
2H5I (DOCK)
2H5J (DOCK)
2H65 (DOCK)
2J30 (DOCK)
2J31 (DOCK)
2J32 (DOCK)
2J33 (DOCK)
2XYG (DOCK)
2XYH (DOCK)
2XYP (DOCK)
2XZD (DOCK)
2XZT (DOCK)
2Y0B (DOCK)
3DEH (DOCK)
3DEI (DOCK)
3DEJ (DOCK)
3DEK (DOCK)
3EDQ (DOCK)
3GJQ (DOCK)
3GJR (DOCK)
3GJS (DOCK)
3GJT (DOCK)
3H0E (DOCK)
3ITN (DOCK)
3KJF (DOCK)
3PCX (DOCK)
3PD0 (DOCK)
3PD1 (DOCK)
CASP3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 987 29 1 5
Binding ≤ 1μM 792 17 0 3
Functional ≤ 10μM 1 0 0 0

Reactome Network (12)

Reactome ID Description Species
REACT_607 Activation of caspases through apoptosome-mediated cleavage Homo sapiens
REACT_13462 Activation of DNA fragmentation factor Homo sapiens
REACT_13579 Apoptotic cleavage of cell adhesion proteins Homo sapiens
REACT_107 Apoptotic cleavage of cellular proteins Homo sapiens
REACT_13541 Caspase-mediated cleavage of cytoskeletal proteins Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_13526 NADE modulates death signalling Homo sapiens
REACT_22128 Role of DCC in regulating apoptosis Homo sapiens
REACT_118607 Signaling by Hippo Homo sapiens
REACT_2190 SMAC binds to IAPs Homo sapiens
REACT_1767 SMAC-mediated dissociation of IAP:caspase complexes Homo sapiens
REACT_13532 Stimulation of the cell death response by PAK-2p34 Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11

Apoptotic cleavage of cellular proteins

Uniprot Swissprot Chembl Description Number Shared
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 168
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 293

Caspase-mediated cleavage of cytoskeletal proteins

Uniprot Swissprot Chembl Description Number Shared
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 168
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 293

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 4

NADE modulates death signalling

Uniprot Swissprot Chembl Description Number Shared
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 62

Role of DCC in regulating apoptosis

Uniprot Swissprot Chembl Description Number Shared
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11

SMAC binds to IAPs

Uniprot Swissprot Chembl Description Number Shared
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11

SMAC-mediated dissociation of IAP:caspase complexes

Uniprot Swissprot Chembl Description Number Shared
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 975 16 2 1
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 75 2 1 2
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 5 0 0 0
CASP5_HUMAN P51878 CHEMBL3131 Caspase-5, Human 4 0 0 0
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 171 7 0 1
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433 10 0 2
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 444 4 1 2
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11 2 0 0
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4 0 0 0
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1 0 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
CASP3-1-E Caspase-3 (cluster #1 Of 2), Eukaryotic 926 22 1 5
CASP3-2-E Caspase-3 (cluster #2 Of 2), Eukaryotic 62 7 0 0
Uniprot Swissprot Chembl Description Number Shared
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 369
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 293
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 168
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 62
CASP1_MOUSE P29452 CHEMBL4800 Caspase-1, Mouse 20
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 4
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 4
CASP5_HUMAN P51878 CHEMBL3131 Caspase-5, Human 4
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 4
GRAB_HUMAN P10144 CHEMBL2316 Granzyme B, Human 4
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 2
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 1
TOP2A_HUMAN P11388 CHEMBL1806 DNA Topoisomerase II Alpha, Human 1
TOP2B_HUMAN Q02880 CHEMBL3396 DNA Topoisomerase II Beta, Human 1
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 1

Most Common Rings