UCSF

Cathepsin B, Human (884 Compounds)

Swissprot:
CATB_HUMAN
Stitch:
CATB_HUMAN
UniProt:
P07858
ChEMBL:
CHEMBL4072
Reactome:
REACT_150180
REACT_150401
REACT_121399
REACT_118632
PDB:
1CSB (DOCK)
1GMY (DOCK)
1HUC (DOCK)
1PBH (DOCK)
2IPP (DOCK)
2PBH (DOCK)
3AI8 (DOCK)
3CBJ (DOCK)
3CBK (DOCK)
3K9M (DOCK)
3PBH (DOCK)
CTSB

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 884 29 10 15
Binding ≤ 1μM 535 17 3 7

Reactome Network (4)

Reactome ID Description Species
REACT_150180 Assembly of collagen fibrils and other multimeric structures Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_121399 MHC class II antigen presentation Homo sapiens
REACT_118632 Trafficking and processing of endosomal TLR Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 423
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 76
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 267

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 1
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 326
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 423
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 3

MHC class II antigen presentation

Uniprot Swissprot Chembl Description Number Shared
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 20
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 1
CATE_HUMAN P14091 CHEMBL3092 Cathepsin E, Human 1
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 29
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 20
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 326
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 423
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 76
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 267

Trafficking and processing of endosomal TLR

Uniprot Swissprot Chembl Description Number Shared
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 326
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 423
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 76
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 267
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CATB_BOVIN P07688 CHEMBL2323 Cathepsin B, Bovin 313 1 0 0
CATB_MOUSE P10605 CHEMBL5187 Cathepsin B, Mouse 11 0 0 1
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 25 0 0 1

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
CATB-1-E Cathepsin B (cluster #1 Of 6), Eukaryotic 1,121 27 6 13
CATB-2-E Cathepsin B (cluster #2 Of 6), Eukaryotic 13 0 0 0
CATB-3-E Cathepsin B (cluster #3 Of 6), Eukaryotic 15 2 4 2
CATB-4-E Cathepsin B (cluster #4 Of 6), Eukaryotic 13 0 0 0
CATB-5-E Cathepsin B (cluster #5 Of 6), Eukaryotic 18 1 0 0
CATB-6-E Cathepsin B (cluster #6 Of 6), Eukaryotic 5 0 0 0
Uniprot Swissprot Chembl Description Number Shared
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 423
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 326
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 267
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 210
CAN2_HUMAN P17655 CHEMBL2382 Calpain 2, Human 182
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 76
CAN1_PIG P35750 CHEMBL4062 Calpain 1, Pig 75
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 44
CATB_BOVIN P07688 CHEMBL2323 Cathepsin B, Bovin 33
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 30
CPNS1_PIG P04574 CHEMBL2205 Calpain Small Subunit 1, Pig 30
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 29
CPNS1_HUMAN P04632 CHEMBL4962 Calpain Small Subunit 1, Human 27
A3EZI9_9HEPC A3EZI9 CHEMBL4893 Hepatitis C Virus NS3 Protease/helicase, 9hepc 24
PAPA1_CARPA P00784 CHEMBL4779 Papain, Carpa 24
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 20
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 20
CATL1_RAT P07154 CHEMBL2305 Cathepsin L, Rat 17
CATS_MOUSE O70370 CHEMBL4098 Cathepsin S, Mouse 17
CAN2_PIG P43367 CHEMBL4143 Calpain 2, Pig 16
Q95PM0_TRYBR Q95PM0 CHEMBL4188 Rhodesain, Trybr 16
CATK_RABIT P43236 CHEMBL3349 Cathepsin K, Rabit 13
CAN1_MOUSE O35350 CHEMBL4210 Calpain 1, Mouse 12
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 12
CPNS1_MOUSE O88456 CHEMBL4209 Calpain Small Subunit 1, Mouse 12
Z100494 Z100494 CHEMBL612655 C2C12 (Myoblast Cells) 12
CATB_MOUSE P10605 CHEMBL5187 Cathepsin B, Mouse 11
Z100256 Z100256 CHEMBL612443 Proteasome 11
Q9N6S8_PLAFA Q9N6S8 CHEMBL5800 Falcipain 2, Plafa 10
CATK_MOUSE P55097 CHEMBL1075277 Cathepsin K, Mouse 9
CATL1_MOUSE P06797 CHEMBL5291 Cathepsin L1, Mouse 9
CATS_RAT Q02765 CHEMBL1075217 Cathepsin S, Rat 9
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 7
Z50587 Z50587 CHEMBL372 Homo Sapiens 7
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 4
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 4
CATK_RAT O35186 CHEMBL3034 Cathepsin K, Rat 4
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 4
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 4
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 3
D2K2A8_9HEPC D2K2A8 CHEMBL2364 Hepatitis C Virus NS4A Protein, 9hepc 3
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 3
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 3
Q6R7Z5_9TRYP Q6R7Z5 CHEMBL5832 Cathepsin B-like Cysteine Protease, 9tryp 3
Q9NBA7_PLAFA Q9NBA7 CHEMBL4510 Cysteine Protease Falcipain-3, Plafa 3
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 3
CAN2_CHICK Q92178 CHEMBL5563 Calpain 2, Chick 2
CANX_CHICK P00789 CHEMBL3147 Calpain 1/2, Chick 2
CASP1_MOUSE P29452 CHEMBL4800 Caspase-1, Mouse 2
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 2
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 2
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 2
CEL2A_PIG P08419 CHEMBL2407 Elastase 2A, Pig 2
CELA1_PIG P00772 CHEMBL3517 Elastase 1, Pig 2
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 2
Q3HTL5_PLAFA Q3HTL5 CHEMBL3488 Falcipain 2B, Plafa 2
Q95WR6_LEIDO Q95WR6 CHEMBL4751 Cysteine Protease, Leido 2
TRPA1_HUMAN O75762 CHEMBL6007 Transient Receptor Potential Cation Channel Subfamily A Member 1, Human 2
TRPA1_MOUSE Q8BLA8 CHEMBL1075310 Transient Receptor Potential Cation Channel Subfamily A Member 1, Mouse 2
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 1
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 1
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1
CATD_BOVIN P80209 CHEMBL4106 Cathepsin D, Bovin 1
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 1
CATE_HUMAN P14091 CHEMBL3092 Cathepsin E, Human 1
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 1
CATL3_PARTE Q94715 CHEMBL4097 Cathepsin L2, Parte 1
CATZ_HUMAN Q9UBR2 CHEMBL4160 Cathepsin Z, Human 1
CELA1_HUMAN Q9UNI1 CHEMBL3000 Elastase 1, Human 1
LMCPB_LEIME P36400 CHEMBL3821 Cysteine Proteinase B, Leime 1
PEPA_HUMAN P00790 CHEMBL3295 Pepsin A, Human 1
PEPA_PIG P00791 CHEMBL2714 Pepsin A, Pig 1
PLM2_PLAFA P46925 CHEMBL4414 Plasmepsin 2, Plafa 1
PLMN_BOVIN P06868 CHEMBL2957 Plasminogen, Bovin 1
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
POLG_WNV P06935 CHEMBL5419 Genome Polyprotein, Wnv 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
Q9NAW4_PLAFA Q9NAW4 CHEMBL1697661 Cysteine Protease Falcipain-3, Plafa 1
Q9NBD4_PLAFA Q9NBD4 CHEMBL5801 Cysteine Protease Falcipain-2, Plafa 1
RENI_HUMAN P00797 CHEMBL286 Renin, Human 1
RENI_RAT P08424 CHEMBL2322 Renin, Rat 1
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 1
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 1
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 1

Most Common Rings