UCSF

Anthrax Lethal Factor, Bacan (193 Compounds)

Swissprot:
LEF_BACAN
Stitch:
LEF_BACAN
UniProt:
P15917
ChEMBL:
CHEMBL4372
Reactome:
REACT_228255
PDB:
1J7N (DOCK)
1JKY (DOCK)
1PWP (DOCK)
1PWQ (DOCK)
1PWU (DOCK)
1PWV (DOCK)
1PWW (DOCK)
1YQY (DOCK)
1ZXV (DOCK)
2L0R (DOCK)
3KWV (DOCK)

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 193 34 7 7
Binding ≤ 1μM 108 8 0 1

Reactome Network (1)

Reactome ID Description Species
REACT_228255 Uptake and function of anthrax toxins Homo sapiens

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
LEF-1-B Anthrax Lethal Factor (cluster #1 Of 2), Bacterial 174 25 4 6
LEF-2-B Anthrax Lethal Factor (cluster #2 Of 2), Bacterial 19 9 3 1
Uniprot Swissprot Chembl Description Number Shared
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 3
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 3
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 3
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 3
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 3
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 2
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 2
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 2
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 2
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 2
Q9AQH7_STAAU Q9AQH7 CHEMBL5643 DnaC Helicase, Staau 2
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 2
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 2
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 2
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 2
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 1
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CETP_HUMAN P11597 CHEMBL3572 Cholesteryl Ester Transfer Protein, Human 1
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 1
DUS3_HUMAN P51452 CHEMBL2635 Dual Specificity Protein Phosphatase 3, Human 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
FDFT_HUMAN P37268 CHEMBL3338 Squalene Synthetase, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 1
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 1
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1
KPCG_HUMAN P05129 CHEMBL2938 Protein Kinase C Gamma, Human 1
KPCI_HUMAN P41743 CHEMBL2598 Protein Kinase C Iota, Human 1
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 1
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 1
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 1
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 1
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 1
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 1
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 1
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 1
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 1
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1
SIRT2_HUMAN Q8IXJ6 CHEMBL4462 NAD-dependent Deacetylase Sirtuin 2, Human 1
THA_HUMAN P10827 CHEMBL1860 Thyroid Hormone Receptor Alpha, Human 1
THB_HUMAN P10828 CHEMBL1947 Thyroid Hormone Receptor Beta-1, Human 1
Z104295 Z104295 CHEMBL1907601 Cyclin-dependent Kinase 4/cyclin D1 1

Most Common Rings