UCSF

Matrix Metalloproteinase 7, Human (467 Compounds)

Swissprot:
MMP7_HUMAN
Stitch:
MMP7_HUMAN
UniProt:
P09237
ChEMBL:
CHEMBL4073
Reactome:
REACT_118682
REACT_150180
REACT_150401
REACT_118572
PDB:
1MMP (DOCK)
1MMQ (DOCK)
1MMR (DOCK)
2DDY (DOCK)
2Y6C (DOCK)
2Y6D (DOCK)
MMP7

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 467 10 4 22
Binding ≤ 1μM 229 6 4 16
Functional ≤ 10μM 1 0 0 0

Reactome Network (4)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150180 Assembly of collagen fibrils and other multimeric structures Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 16
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 291
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 53
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 11
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 12
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 373
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 1
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 275
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 386
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 119
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 194

Assembly of collagen fibrils and other multimeric structures

Uniprot Swissprot Chembl Description Number Shared
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 291
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 386
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 194

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 4
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 24
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 16
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 45
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 291
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 53
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 11
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 373
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 275
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 386
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 119
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 194

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 4
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 2
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 6
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 3
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 16
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 45
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 291
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 53
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 11
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 373
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 275
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 386
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 119
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 194
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 289 8 4 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 507 9 8 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 30 1 1 3
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2,665 22 9 44
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2,765 37 17 44
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2,212 22 9 40
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 980 16 6 25
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2,243 31 11 34

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 386
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 373
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 291
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 275
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 194
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 119
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 53
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 45
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 25
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 19
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 16
MMP11_MOUSE Q02853 CHEMBL3412 Matrix Metalloproteinase 11, Mouse 14
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 12
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 11
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 9
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 7
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 6
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 6
NEP_RAT P07861 CHEMBL3369 Neprilysin, Rat 5
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 4
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 3
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 3
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 2
FCER2_HUMAN P06734 CHEMBL2940 Immunoglobulin Epsilon Fc Receptor, Human 2
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 2
Z50264 Z50264 CHEMBL356 Streptococcus Pyogenes 2
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 1
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 1
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 1
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 1
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 1

Most Common Rings