UCSF

TNF-alpha, Human (93 Compounds)

Swissprot:
TNFA_HUMAN
Stitch:
TNFA_HUMAN
UniProt:
P01375
ChEMBL:
CHEMBL1825
Reactome:
REACT_1432
REACT_27161
PDB:
1A8M (DOCK)
1TNF (DOCK)
2AZ5 (DOCK)
2E7A (DOCK)
2TUN (DOCK)
2ZJC (DOCK)
2ZPX (DOCK)
3ALQ (DOCK)
3IT8 (DOCK)
3L9J (DOCK)
4TSV (DOCK)
5TSW (DOCK)
TNF

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 93 4 1 4
Binding ≤ 1μM 62 1 1 4
Functional ≤ 10μM 8 3 1 2

Reactome Network (2)

Reactome ID Description Species
REACT_1432 TNF signaling Homo sapiens
REACT_27161 Transcriptional regulation of white adipocyte differentiation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 31

Transcriptional regulation of white adipocyte differentiation

Uniprot Swissprot Chembl Description Number Shared
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CDK8_HUMAN P49336 CHEMBL5719 Cell Division Protein Kinase 8, Human 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 28
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 19
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 18
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 18
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 14
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 14
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 10
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 6
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 5
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 4
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 4
ADA17_RAT Q9Z1K9 CHEMBL2523 ADAM17, Rat 3
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 3
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 3
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 3
Z50587 Z50587 CHEMBL372 Homo Sapiens 3
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 3
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 2
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 2
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 2
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 2
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 2
Z102116 Z102116 CHEMBL613159 Toxoplasma Gondii RH 2
Z50472 Z50472 CHEMBL612888 Toxoplasma Gondii 2
Z80523 Z80523 CHEMBL614944 SW1353 2
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 1
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 1
ANKK1_HUMAN Q8NFD2 CHEMBL5547 Ankyrin Repeat And Protein Kinase Domain-containing Protein 1, Human 1
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 1
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 1
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 1
CDK8_HUMAN P49336 CHEMBL5719 Cell Division Protein Kinase 8, Human 1
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 1
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 1
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 1
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 1
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 1
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 1
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 1
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 1
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 1
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 1
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 1
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 1
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 1
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 1
FAK2_HUMAN Q14289 CHEMBL5469 Protein Tyrosine Kinase 2 Beta, Human 1
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 1
HSPB1_HUMAN P04792 CHEMBL5976 Heat Shock Protein Beta-1, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
LTK_HUMAN P29376 CHEMBL5627 Leukocyte Tyrosine Kinase Receptor, Human 1
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 1
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 1
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 1
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 1
MK15_HUMAN Q8TD08 CHEMBL5198 Mitogen-activated Protein Kinase 15, Human 1
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 1
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 1
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 1
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 1
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 1
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 1
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 1
MUSK_HUMAN O15146 CHEMBL5684 Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human 1
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 1
NTRK3_HUMAN Q16288 CHEMBL5608 NT-3 Growth Factor Receptor, Human 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 1
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 1
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein Kinase Receptor Tie-1, Human 1
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 1
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 1
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 1
Z50591 Z50591 CHEMBL613489 Bos Taurus 1
Z81011 Z81011 CHEMBL614840 Human Cell Lines 1

Most Common Rings