UCSF

MAP Kinase P38 Alpha, Mouse (220 Compounds)

Swissprot:
MK14_MOUSE
Stitch:
MK14_MOUSE
UniProt:
P47811
ChEMBL:
CHEMBL2336
Reactome:
REACT_237946
REACT_205688
REACT_204811
REACT_259068
REACT_258600
REACT_243212
REACT_215063
REACT_198696
REACT_211125
REACT_188970
REACT_207601
REACT_250548
REACT_257088
PDB:
1LEW (DOCK)
1LEZ (DOCK)
1P38 (DOCK)
1YW2 (DOCK)
1YWR (DOCK)
2EWA (DOCK)
2GHL (DOCK)
2GHM (DOCK)
2GTM (DOCK)
2GTN (DOCK)
2OZA (DOCK)
2PUU (DOCK)
3P4K (DOCK)
3P5K (DOCK)
3P78 (DOCK)
3P79 (DOCK)
3P7A (DOCK)
3P7B (DOCK)
3P7C (DOCK)
3PY3 (DOCK)
Mapk14

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 220 5 1 7
Binding ≤ 1μM 204 5 1 7

Reactome Network (13)

Reactome ID Description Species
REACT_237946 activated TAK1 mediates p38 MAPK activation Mus musculus
REACT_205688 Activation of PPARGC1A (PGC-1alpha) by phosphorylation Mus musculus
REACT_204811 Activation of the AP-1 family of transcription factors Mus musculus
REACT_259068 ADP signalling through P2Y purinoceptor 1 Mus musculus
REACT_258600 CDO in myogenesis Mus musculus
REACT_243212 DSCAM interactions Mus musculus
REACT_215063 ERK/MAPK targets Mus musculus
REACT_198696 KSRP destabilizes mRNA Mus musculus
REACT_211125 NOD1/2 Signaling Pathway Mus musculus
REACT_188970 Oxidative Stress Induced Senescence Mus musculus
REACT_207601 p38MAPK events Mus musculus
REACT_250548 Platelet sensitization by LDL Mus musculus
REACT_257088 VEGFA-VEGFR2 Pathway Mus musculus
Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38

Activation of the AP-1 family of transcription factors

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52

CDO in myogenesis

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38

DSCAM interactions

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38

ERK/MAPK targets

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52

KSRP destabilizes mRNA

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52

NOD1/2 Signaling Pathway

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38

Oxidative Stress Induced Senescence

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52

p38MAPK events

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38

VEGFA-VEGFR2 Pathway

Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2,843 68 14 56
MK14_RAT P70618 CHEMBL4825 MAP Kinase P38 Alpha, Rat 55 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52 0 0 0
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38 0 0 0
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38 0 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
MK14-1-E MAP Kinase P38 Alpha (cluster #1 Of 3), Eukaryotic 2,843 52 12 51
MK14-2-E MAP Kinase P38 Alpha (cluster #2 Of 3), Eukaryotic 244 14 2 4
MK14-3-E MAP Kinase P38 Alpha (cluster #3 Of 3), Eukaryotic 19 2 0 1
Uniprot Swissprot Chembl Description Number Shared
MK11_MOUSE Q9WUI1 CHEMBL4335 MAP Kinase P38 Beta, Mouse 52
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 50
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 10
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 10
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 8
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 8
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 8
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 7
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 7
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 6
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 5
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 4
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 4
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 4
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 4
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 3
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 3
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 3
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 3
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 3
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 3
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 3
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 3
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 3
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 3
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 3
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 3
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 3
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 3
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 3
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 3
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 3
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 2
ACV1B_HUMAN P36896 CHEMBL5310 Activin Receptor Type-1B, Human 2
ADCK4_HUMAN Q96D53 CHEMBL5753 Uncharacterized AarF Domain-containing Protein Kinase 4, Human 2
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 2
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 2
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 2
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 2
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 2
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 2
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 2
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 2
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
KC1AL_HUMAN Q8N752 CHEMBL5520 Casein Kinase I Isoform Alpha-like, Human 2
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 2
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
KS6A1_HUMAN Q15418 CHEMBL2553 Ribosomal Protein S6 Kinase Alpha 1, Human 2
KS6A6_HUMAN Q9UK32 CHEMBL4924 Ribosomal Protein S6 Kinase Alpha 6, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 2
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 2
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 2
Q5SC61_TOXGO Q5SC61 CHEMBL6051 Mitogen-activated Protein Kinase 1, Toxgo 2
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 2
ST32B_HUMAN Q9NY57 CHEMBL5912 Serine/threonine-protein Kinase 32B, Human 2
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 2
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 2
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 2
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 2
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 2
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 1
ANKK1_HUMAN Q8NFD2 CHEMBL5547 Ankyrin Repeat And Protein Kinase Domain-containing Protein 1, Human 1
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 1
CDK8_HUMAN P49336 CHEMBL5719 Cell Division Protein Kinase 8, Human 1
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 1
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 1
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 1
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 1
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 1
FAK2_HUMAN Q14289 CHEMBL5469 Protein Tyrosine Kinase 2 Beta, Human 1
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 1
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 1
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 1
HSPB1_HUMAN P04792 CHEMBL5976 Heat Shock Protein Beta-1, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
LTK_HUMAN P29376 CHEMBL5627 Leukocyte Tyrosine Kinase Receptor, Human 1
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 1
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 1
MK14_RAT P70618 CHEMBL4825 MAP Kinase P38 Alpha, Rat 1
MK15_HUMAN Q8TD08 CHEMBL5198 Mitogen-activated Protein Kinase 15, Human 1
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 1
MUSK_HUMAN O15146 CHEMBL5684 Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human 1
NR1I2_HUMAN O75469 CHEMBL3401 Pregnane X Receptor, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 1
NTRK3_HUMAN Q16288 CHEMBL5608 NT-3 Growth Factor Receptor, Human 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 1
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein Kinase Receptor Tie-1, Human 1
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1

Most Common Rings