UCSF

Cyclooxygenase-1, Human (969 Compounds)

Swissprot:
PGH1_HUMAN
Stitch:
PGH1_HUMAN
UniProt:
P23219
ChEMBL:
CHEMBL221
Reactome:
REACT_1396
REACT_150149
PDB:
PTGS1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 969 95 65 44
Binding ≤ 1μM 436 53 31 22
Functional ≤ 10μM 48 10 10 11

Reactome Network (2)

Reactome ID Description Species
REACT_1396 COX reactions Homo sapiens
REACT_150149 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 2
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 771
PTGES_HUMAN O14684 CHEMBL5658 Prostaglandin E Synthase, Human 1
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 100 16 12 12
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 37 7 3 3
PGH1_RABIT O97554 CHEMBL3334 Cyclooxygenase-1, Rabit 9 1 1 1
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 252 34 20 18
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 198 36 21 23
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 2,153 141 77 52

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
PGH1-1-E Cyclooxygenase-1 (cluster #1 Of 6), Eukaryotic 834 44 17 19
PGH1-2-E Cyclooxygenase-1 (cluster #2 Of 6), Eukaryotic 351 70 53 38
PGH1-3-E Cyclooxygenase-1 (cluster #3 Of 6), Eukaryotic 70 17 5 3
PGH1-4-E Cyclooxygenase-1 (cluster #4 Of 6), Eukaryotic 47 7 6 3
PGH1-5-E Cyclooxygenase-1 (cluster #5 Of 6), Eukaryotic 108 5 6 0
PGH1-6-E Cyclooxygenase-1 (cluster #6 Of 6), Eukaryotic 61 7 6 7
Uniprot Swissprot Chembl Description Number Shared
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 769
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 94
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 85
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 59
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 51
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 44
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 39
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 30
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 11
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 8
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 8
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 8
Z50587 Z50587 CHEMBL372 Homo Sapiens 5
FABPL_RAT P02692 CHEMBL5738 Fatty Acid-binding Protein, Liver, Rat 4
IL8_HUMAN P10145 CHEMBL2157 Interleukin-8, Human 4
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 4
Z102213 Z102213 CHEMBL613416 Blood 4
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 3
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 3
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 3
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 3
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 3
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 3
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 3
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 3
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 3
CLTR2_HUMAN Q9NS75 CHEMBL4330 Cysteinyl Leukotriene Receptor 2, Human 3
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 3
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 3
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 3
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 3
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 3
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 3
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 3
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 3
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 3
ACV1B_HUMAN P36896 CHEMBL5310 Activin Receptor Type-1B, Human 2
ADCK4_HUMAN Q96D53 CHEMBL5753 Uncharacterized AarF Domain-containing Protein Kinase 4, Human 2
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 2
ALBU_BOVIN P02769 CHEMBL3728 Serum Albumin, Bovin 2
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 2
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 2
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 2
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 2
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 2
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 2
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 2
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 2
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 2
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 2
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 2
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 2
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
KC1AL_HUMAN Q8N752 CHEMBL5520 Casein Kinase I Isoform Alpha-like, Human 2
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 2
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 2
KS6A1_HUMAN Q15418 CHEMBL2553 Ribosomal Protein S6 Kinase Alpha 1, Human 2
KS6A6_HUMAN Q9UK32 CHEMBL4924 Ribosomal Protein S6 Kinase Alpha 6, Human 2
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 2
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 2
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 2
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 2
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 2
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 2
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 2
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 2
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 2
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 2
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 2
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 2
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 2
Q5SC61_TOXGO Q5SC61 CHEMBL6051 Mitogen-activated Protein Kinase 1, Toxgo 2
Q8SPQ9_CANFA Q8SPQ9 CHEMBL4033 Cyclooxygenase-2, Canine 2
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 2
S22A6_MOUSE Q8VC69 CHEMBL5653 Solute Carrier Family 22 Member 6, Mouse 2
S22AK_MOUSE Q80UJ1 CHEMBL5269 Solute Carrier Family 22 Member 20, Mouse 2
SC5A2_HUMAN P31639 CHEMBL3884 Sodium/glucose Cotransporter 2, Human 2
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 2
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 2
ST32B_HUMAN Q9NY57 CHEMBL5912 Serine/threonine-protein Kinase 32B, Human 2
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 2
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 2
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 2
THAS_RAT P49430 CHEMBL4028 Thromboxane-A Synthase, Rat 2
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 2
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 2
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 2
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 2
Z102306 Z102306 CHEMBL613606 Aorta 2
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 2
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 2
A4_HUMAN P05067 CHEMBL2487 Beta Amyloid A4 Protein, Human 1
AHR_RABIT O02747 CHEMBL4725 Aryl Hydrocarbon Receptor, Rabit 1
AL5AP_HUMAN P20292 CHEMBL4550 5-lipoxygenase Activating Protein, Human 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
B5SU02_9CNID B5SU02 CHEMBL1075028 Alpha Carbonic Anhydrase, 9cnid 1
C0IX24_9CNID C0IX24 CHEMBL1649055 Carbonic Anhydrase, 9cnid 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 1
CAH_METTE P40881 CHEMBL3932 Carbonic Anhydrase, Mette 1
CAN_YEAST P53615 CHEMBL5931 Carbonic Anhydrase, Yeast 1
COX2_SHEEP O78750 CHEMBL1250404 Cytochrome C Oxidase Subunit 2, Sheep 1
CYNT_MYCTU O53573 CHEMBL6068 Carbonic Anhydrase, Myctu 1
DHB3_RAT O54939 CHEMBL1075158 Testosterone 17-beta-dehydrogenase 3, Rat 1
DHRS9_RAT Q8VD48 CHEMBL1075220 Dehydrogenase/reductase SDR Family Member 9, Rat 1
FABPI_HUMAN P12104 CHEMBL4879 Fatty Acid Binding Protein Intestinal, Human 1
FAS_HUMAN P49327 CHEMBL4158 Fatty Acid Synthase, Human 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LIPS_RAT P15304 CHEMBL5582 Hormone-sensitive Lipase, Rat 1
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 1
LT4R1_HUMAN Q15722 CHEMBL3911 Leukotriene B4 Receptor 1, Human 1
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 1
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
MTSI_SPISQ P15840 CHEMBL4373 CpG DNA Methylase, Spisq 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOS2_HUMAN P35228 CHEMBL4481 Nitric Oxide Synthase, Inducible, Human 1
NQO2_HUMAN P16083 CHEMBL3959 Quinone Reductase 2, Human 1
PDE3A_RAT Q62865 CHEMBL2711 Phosphodiesterase 3A, Rat 1
PDE3B_RAT Q63085 CHEMBL3580 Phosphodiesterase 3B, Rat 1
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 1
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 1
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 1
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 1
PDE5A_RAT O54735 CHEMBL4567 Phosphodiesterase 5A, Rat 1
PE2R1_HUMAN P34995 CHEMBL1811 Prostanoid EP1 Receptor, Human 1
PE2R2_HUMAN P43116 CHEMBL1881 Prostanoid EP2 Receptor, Human 1
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 1
PGH2_RABIT O02768 CHEMBL1293198 Prostaglandin G/H Synthase 2, Rabit 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
PTGES_HUMAN O14684 CHEMBL5658 Prostaglandin E Synthase, Human 1
Q5AJ71_CANAL Q5AJ71 CHEMBL5337 Carbonic Anhydrase, Canal 1
Q8HY88_BOVIN Q8HY88 CHEMBL1075183 Potassium Channel Subfamily K Member 2, Bovin 1
Q8HZR1_CANFA Q8HZR1 CHEMBL4133 Cyclooxygenase-1, Canine 1
Q9BEG3_BOVIN Q9BEG3 CHEMBL2980 Arachidonate 5-lipoxygenase, Bovin 1
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 1
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 1
TRPV1_HUMAN Q8NER1 CHEMBL4794 Vanilloid Receptor, Human 1
TRPV1_RAT O35433 CHEMBL5102 Vanilloid Receptor, Rat 1
TTHY_HUMAN P02766 CHEMBL3194 Transthyretin, Human 1
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 1
Z100741 Z100741 CHEMBL614867 MC9 (Mast Cells) 1
Z50512 Z50512 CHEMBL369 Cavia Porcellus 1
Z50588 Z50588 CHEMBL373 Canis Familiaris 1
Z50589 Z50589 CHEMBL612670 Felis Catus 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80492 Z80492 CHEMBL614924 SK-N-SH (Neuroblastoma Cells) 1
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1
Z81267 Z81267 CHEMBL614723 Mononuclear Cell Line 1

Most Common Rings