UCSF

Leukotriene A4 Hydrolase, Human (423 Compounds)

Swissprot:
LKHA4_HUMAN
Stitch:
LKHA4_HUMAN
UniProt:
P09960
ChEMBL:
CHEMBL4618
Reactome:
REACT_150420
PDB:
1GW6 (DOCK)
1H19 (DOCK)
1HS6 (DOCK)
1SQM (DOCK)
2R59 (DOCK)
2VJ8 (DOCK)
3B7R (DOCK)
3B7S (DOCK)
3B7T (DOCK)
3B7U (DOCK)
3CHO (DOCK)
3CHP (DOCK)
3CHQ (DOCK)
3CHR (DOCK)
3CHS (DOCK)
3FH5 (DOCK)
3FH7 (DOCK)
3FH8 (DOCK)
3FHE (DOCK)
3FTS (DOCK)
3FTU (DOCK)
3FTV (DOCK)
3FTW (DOCK)
3FTX (DOCK)
3FTY (DOCK)
3FTZ (DOCK)
3FU0 (DOCK)
3FU3 (DOCK)
3FU5 (DOCK)
3FU6 (DOCK)
3FUD (DOCK)
3FUE (DOCK)
3FUF (DOCK)
3FUH (DOCK)
3FUI (DOCK)
3FUJ (DOCK)
3FUK (DOCK)
3FUL (DOCK)
3FUM (DOCK)
3FUN (DOCK)
LTA4H

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 423 29 4 10
Binding ≤ 1μM 352 24 4 10
Functional ≤ 10μM 97 12 3 3

Reactome Network (1)

Reactome ID Description Species
REACT_150420 Synthesis of Leukotrienes (LT) and Eoxins (EX) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
LKHA4_CAVPO P19602 CHEMBL5786 Leukotriene A-4 Hydrolase, Guinea Pig 56 0 0 0
LKHA4_MOUSE P24527 CHEMBL3738 Leukotriene A4 Hydrolase, Mouse 28 0 0 0
LKHA4_RAT P30349 CHEMBL2400 Leukotriene A4 Hydrolase, Rat 18 0 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
LKHA4-1-E Leukotriene A4 Hydrolase (cluster #1 Of 2), Eukaryotic 87 2 2 3
LKHA4-2-E Leukotriene A4 Hydrolase (cluster #2 Of 2), Eukaryotic 397 28 2 7
Uniprot Swissprot Chembl Description Number Shared
LKHA4_MOUSE P24527 CHEMBL3738 Leukotriene A4 Hydrolase, Mouse 28
LKHA4_RAT P30349 CHEMBL2400 Leukotriene A4 Hydrolase, Rat 18
AMPN_HUMAN P15144 CHEMBL1907 Aminopeptidase N, Human 12
AMPB_HUMAN Q9H4A4 CHEMBL2432 Aminopeptidase B, Human 11
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 11
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 9
Z50587 Z50587 CHEMBL372 Homo Sapiens 5
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 3
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 3
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 2
AMPN_PIG P15145 CHEMBL2590 Aminopeptidase N, Pig 2
HYES_MOUSE P34914 CHEMBL4140 Epoxide Hydratase, Mouse 2
LCAP_RAT P97629 CHEMBL3712 Cystinyl Aminopeptidase, Rat 2
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 2
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 2
Z100741 Z100741 CHEMBL614867 MC9 (Mast Cells) 2
Z50594 Z50594 CHEMBL375 Mus Musculus 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
Z80419 Z80419 CHEMBL614772 RBL-1 (Basophilic Leukemia Cells) 2
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 1
ACE_RABIT P12822 CHEMBL4074 Angiotensin-converting Enzyme, Rabit 1
ACE_RAT P47820 CHEMBL2625 Angiotensin-converting Enzyme, Rat 1
AMP1_PLAFQ O96935 CHEMBL4117 Zinc Aminopeptidase, Plafq 1
AMPB_MOUSE Q8VCT3 CHEMBL2836 Aminopeptidase B, Mouse 1
AMPB_RAT O09175 CHEMBL2452 Aminopeptidase B, Rat 1
AMPE_PIG Q95334 CHEMBL4868 Aminopeptidase A, Pig 1
AMPL_BOVIN P00727 CHEMBL1671610 Cytosol Aminopeptidase, Bovin 1
AMPL_HUMAN P28838 CHEMBL3965 Leucine Aminopeptidase, Human 1
DAPE_HAEIN P44514 CHEMBL1075192 Succinyl-diaminopimelate Desuccinylase, Haein 1
DPP2_RAT Q9EPB1 CHEMBL4352 Dipeptidyl Peptidase II, Rat 1
DPP3_RAT O55096 CHEMBL2233 Dipeptidyl Peptidase III, Rat 1
DPP4_RAT P14740 CHEMBL4653 Dipeptidyl Peptidase IV, Rat 1
DPP6_RAT P46101 CHEMBL4353 Dipeptidyl Peptidase VI, Rat 1
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 1
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1
NEP_RAT P07861 CHEMBL3369 Neprilysin, Rat 1
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 1
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 1
RENI_HUMAN P00797 CHEMBL286 Renin, Human 1
THER_BACTH P00800 CHEMBL3392 Thermolysin, Bacth 1
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1