UCSF

Cyclooxygenase-2, Human (2,153 Compounds)

Swissprot:
PGH2_HUMAN
Stitch:
PGH2_HUMAN
UniProt:
P35354
ChEMBL:
CHEMBL230
Reactome:
REACT_11213
REACT_150422
REACT_150149
PDB:
1V0X (DOCK)
PTGS2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,153 141 77 52
Binding ≤ 1μM 1,551 79 45 39
Functional ≤ 10μM 49 9 6 6

Reactome Network (3)

Reactome ID Description Species
REACT_11213 Nicotinamide salvaging Homo sapiens
REACT_150422 Synthesis of 15-eicosatetraenoic acid derivatives Homo sapiens
REACT_150149 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 2
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 771
PTGES_HUMAN O14684 CHEMBL5658 Prostaglandin E Synthase, Human 1
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 90 15 11 11
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 250 33 15 9
PGH2_RABIT O02768 CHEMBL1293198 Prostaglandin G/H Synthase 2, Rabit 10 2 2 1
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 279 32 18 16
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 284 34 17 15
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 969 95 65 44

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
PGH2-1-E Cyclooxygenase-2 (cluster #1 Of 8), Eukaryotic 896 75 38 27
PGH2-2-E Cyclooxygenase-2 (cluster #2 Of 8), Eukaryotic 35 6 4 1
PGH2-3-E Cyclooxygenase-2 (cluster #3 Of 8), Eukaryotic 106 28 14 10
PGH2-4-E Cyclooxygenase-2 (cluster #4 Of 8), Eukaryotic 1,428 55 26 20
PGH2-5-E Cyclooxygenase-2 (cluster #5 Of 8), Eukaryotic 2 2 2 0
PGH2-6-E Cyclooxygenase-2 (cluster #6 Of 8), Eukaryotic 11 8 7 7
PGH2-7-E Cyclooxygenase-2 (cluster #7 Of 8), Eukaryotic 178 7 10 3
PGH2-8-E Cyclooxygenase-2 (cluster #8 Of 8), Eukaryotic 290 27 8 8
Uniprot Swissprot Chembl Description Number Shared
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 769
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 97
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 87
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 83
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 74
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 23
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 21
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 20
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 20
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 16
HYES_HUMAN P34913 CHEMBL2409 Epoxide Hydratase, Human 13
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 12
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 8
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 8
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 5
FABPL_RAT P02692 CHEMBL5738 Fatty Acid-binding Protein, Liver, Rat 4
IL8_HUMAN P10145 CHEMBL2157 Interleukin-8, Human 4
THAS_RAT P49430 CHEMBL4028 Thromboxane-A Synthase, Rat 4
Z50587 Z50587 CHEMBL372 Homo Sapiens 4
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 3
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 3
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 3
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 3
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 3
CLTR2_HUMAN Q9NS75 CHEMBL4330 Cysteinyl Leukotriene Receptor 2, Human 3
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 3
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 3
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 3
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 3
O49150_SOLTU O49150 CHEMBL3317 5-lipoxygenase, Soltu 3
Q8SPQ9_CANFA Q8SPQ9 CHEMBL4033 Cyclooxygenase-2, Canine 3
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 3
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 2
ALBU_BOVIN P02769 CHEMBL3728 Serum Albumin, Bovin 2
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 2
B5SU02_9CNID B5SU02 CHEMBL1075028 Alpha Carbonic Anhydrase, 9cnid 2
C0IX24_9CNID C0IX24 CHEMBL1649055 Carbonic Anhydrase, 9cnid 2
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 2
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 2
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 2
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 2
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 2
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 2
CAH_METTE P40881 CHEMBL3932 Carbonic Anhydrase, Mette 2
CAN_YEAST P53615 CHEMBL5931 Carbonic Anhydrase, Yeast 2
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 2
COX2_HUMAN P00403 CHEMBL6174 Cytochrome C Oxidase Subunit 2, Human 2
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 2
CYNT_MYCTU O53573 CHEMBL6068 Carbonic Anhydrase, Myctu 2
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
Q5AJ71_CANAL Q5AJ71 CHEMBL5337 Carbonic Anhydrase, Canal 2
S22A6_MOUSE Q8VC69 CHEMBL5653 Solute Carrier Family 22 Member 6, Mouse 2
S22AK_MOUSE Q80UJ1 CHEMBL5269 Solute Carrier Family 22 Member 20, Mouse 2
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 2
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 2
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 1
AHR_RABIT O02747 CHEMBL4725 Aryl Hydrocarbon Receptor, Rabit 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CETP_HUMAN P11597 CHEMBL3572 Cholesteryl Ester Transfer Protein, Human 1
CISD1_HUMAN Q9NZ45 CHEMBL1795168 CDGSH Iron-sulfur Domain-containing Protein 1, Human 1
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 1
COX2_SHEEP O78750 CHEMBL1250404 Cytochrome C Oxidase Subunit 2, Sheep 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 1
DHRS9_RAT Q8VD48 CHEMBL1075220 Dehydrogenase/reductase SDR Family Member 9, Rat 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
FABPI_HUMAN P12104 CHEMBL4879 Fatty Acid Binding Protein Intestinal, Human 1
FAS_HUMAN P49327 CHEMBL4158 Fatty Acid Synthase, Human 1
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 1
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 1
HSC82_YEAST P15108 CHEMBL4199 Heat Shock Protein HSP 90 (HSC82), Yeast 1
HSP82_YEAST P02829 CHEMBL3536 Heat Shock Protein HSP 90 (HSP82), Yeast 1
LIPS_RAT P15304 CHEMBL5582 Hormone-sensitive Lipase, Rat 1
LT4R1_HUMAN Q15722 CHEMBL3911 Leukotriene B4 Receptor 1, Human 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
NQO2_HUMAN P16083 CHEMBL3959 Quinone Reductase 2, Human 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
PTGES_HUMAN O14684 CHEMBL5658 Prostaglandin E Synthase, Human 1
Q8HZR1_CANFA Q8HZR1 CHEMBL4133 Cyclooxygenase-1, Canine 1
Q9BEG3_BOVIN Q9BEG3 CHEMBL2980 Arachidonate 5-lipoxygenase, Bovin 1
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 1
SRC_RAT Q9WUD9 CHEMBL3014 Tyrosine-protein Kinase SRC, Rat 1
TTHY_HUMAN P02766 CHEMBL3194 Transthyretin, Human 1
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 1
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 1
Z100741 Z100741 CHEMBL614867 MC9 (Mast Cells) 1
Z102213 Z102213 CHEMBL613416 Blood 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 1
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 1
Z81267 Z81267 CHEMBL614723 Mononuclear Cell Line 1

Most Common Rings