UCSF

Heat Shock Protein HSP 90-alpha, Human (236 Compounds)

Swissprot:
HS90A_HUMAN
Stitch:
HS90A_HUMAN
UniProt:
P07900
ChEMBL:
CHEMBL3880
Reactome:
REACT_200624
REACT_12477
REACT_228063
REACT_200744
REACT_200775
REACT_15364
REACT_15451
REACT_15296
REACT_160086
REACT_160315
REACT_163813
REACT_19236
REACT_115852
REACT_115755
REACT_111176
REACT_228166
REACT_228016
REACT_9434
PDB:
1BYQ (DOCK)
1OSF (DOCK)
1UY6 (DOCK)
1UY7 (DOCK)
1UY8 (DOCK)
1UY9 (DOCK)
1UYC (DOCK)
1UYD (DOCK)
1UYE (DOCK)
1UYF (DOCK)
1UYG (DOCK)
1UYH (DOCK)
1UYI (DOCK)
1UYK (DOCK)
1UYL (DOCK)
1YC1 (DOCK)
1YC3 (DOCK)
1YC4 (DOCK)
1YER (DOCK)
1YES (DOCK)
1YET (DOCK)
2BSM (DOCK)
2BT0 (DOCK)
2BUG (DOCK)
2BYH (DOCK)
2BYI (DOCK)
2BZ5 (DOCK)
2C2L (DOCK)
2CCS (DOCK)
2CCT (DOCK)
2CCU (DOCK)
2CDD (DOCK)
2FWY (DOCK)
2FWZ (DOCK)
2H55 (DOCK)
2JJC (DOCK)
2K5B (DOCK)
2QF6 (DOCK)
2QFO (DOCK)
2QG0 (DOCK)
2QG2 (DOCK)
2UWD (DOCK)
2VCI (DOCK)
2VCJ (DOCK)
2WI1 (DOCK)
2WI2 (DOCK)
2WI3 (DOCK)
2WI4 (DOCK)
2WI5 (DOCK)
2WI6 (DOCK)
2WI7 (DOCK)
2XAB (DOCK)
2XDK (DOCK)
2XDL (DOCK)
2XDS (DOCK)
2XDU (DOCK)
2XDX (DOCK)
2XHR (DOCK)
2XHT (DOCK)
2XHX (DOCK)
2XJG (DOCK)
2XJJ (DOCK)
2XJX (DOCK)
2XK2 (DOCK)
2YE2 (DOCK)
2YE3 (DOCK)
2YE4 (DOCK)
2YE5 (DOCK)
2YE6 (DOCK)
2YE7 (DOCK)
2YE8 (DOCK)
2YE9 (DOCK)
2YEA (DOCK)
2YEB (DOCK)
2YEC (DOCK)
2YED (DOCK)
2YEE (DOCK)
2YEF (DOCK)
2YEG (DOCK)
2YEH (DOCK)
2YEI (DOCK)
2YEJ (DOCK)
2YJW (DOCK)
2YJX (DOCK)
2YK2 (DOCK)
2YK9 (DOCK)
2YKB (DOCK)
2YKC (DOCK)
2YKE (DOCK)
2YKI (DOCK)
2YKJ (DOCK)
3B24 (DOCK)
3B25 (DOCK)
3B26 (DOCK)
3B27 (DOCK)
3B28 (DOCK)
3BM9 (DOCK)
3BMY (DOCK)
3D0B (DOCK)
3EKO (DOCK)
3EKR (DOCK)
3FT5 (DOCK)
3FT8 (DOCK)
3HEK (DOCK)
3HHU (DOCK)
3HYY (DOCK)
3HYZ (DOCK)
3HZ1 (DOCK)
3HZ5 (DOCK)
3INW (DOCK)
3INX (DOCK)
3K97 (DOCK)
3K98 (DOCK)
3K99 (DOCK)
3MNR (DOCK)
3O0I (DOCK)
3OW6 (DOCK)
3OWB (DOCK)
3OWD (DOCK)
3Q6M (DOCK)
3Q6N (DOCK)
3QTF (DOCK)
3R4M (DOCK)
3R4N (DOCK)
3R4O (DOCK)
3R4P (DOCK)
3R91 (DOCK)
3R92 (DOCK)
3RKZ (DOCK)
3RLP (DOCK)
3RLQ (DOCK)
3RLR (DOCK)
3T0H (DOCK)
3T0Z (DOCK)
3T10 (DOCK)
3T1K (DOCK)
3T2S (DOCK)
HSP90AA1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 236 34 8 18
Binding ≤ 1μM 186 22 5 12
Functional ≤ 10μM 75 14 4 7

Reactome Network (18)

Reactome ID Description Species
REACT_200624 Attenuation phase Homo sapiens
REACT_12477 eNOS activation Homo sapiens
REACT_228063 EPHA-mediated growth cone collapse Homo sapiens
REACT_200744 HSF1 activation Homo sapiens
REACT_200775 HSF1-dependent transactivation Homo sapiens
REACT_15364 Loss of Nlp from mitotic centrosomes Homo sapiens
REACT_15451 Loss of proteins required for interphase microtubule organization from the ce Homo sapiens
REACT_15296 Recruitment of mitotic centrosome proteins and complexes Homo sapiens
REACT_160086 Regulation of actin dynamics for phagocytic cup formation Homo sapiens
REACT_160315 Regulation of PLK1 Activity at G2/M Transition Homo sapiens
REACT_163813 Scavenging by Class F Receptors Homo sapiens
REACT_19236 Sema3A PAK dependent Axon repulsion Homo sapiens
REACT_115852 Signaling by constitutively active EGFR Homo sapiens
REACT_115755 Signaling by ERBB2 Homo sapiens
REACT_111176 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Homo sapiens
REACT_228166 VEGFA-VEGFR2 Pathway Homo sapiens
REACT_228016 VEGFR2 mediated vascular permeability Homo sapiens
REACT_9434 vRNP Assembly Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 124

HSF1 activation

Uniprot Swissprot Chembl Description Number Shared
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 124

HSF1-dependent transactivation

Uniprot Swissprot Chembl Description Number Shared
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 124

Regulation of actin dynamics for phagocytic cup formation

Uniprot Swissprot Chembl Description Number Shared
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 124

Sema3A PAK dependent Axon repulsion

Uniprot Swissprot Chembl Description Number Shared
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 124

Signaling by ERBB2

Uniprot Swissprot Chembl Description Number Shared
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HS90A_MOUSE P07901 CHEMBL4197 Heat Shock Protein HSP 90-alpha, Mouse 38 0 0 0

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
HS90A-1-E Heat Shock Protein HSP 90-alpha (cluster #1 Of 4), Eukaryotic 107 6 5 3
HS90A-2-E Heat Shock Protein HSP 90-alpha (cluster #2 Of 4), Eukaryotic 157 24 3 15
HS90A-3-E Heat Shock Protein HSP 90-alpha (cluster #3 Of 4), Eukaryotic 7 3 0 0
HS90A-4-E Heat Shock Protein HSP 90-alpha (cluster #4 Of 4), Eukaryotic 1 1 0 0
Uniprot Swissprot Chembl Description Number Shared
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 124
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 35
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 26
HSC82_YEAST P15108 CHEMBL4199 Heat Shock Protein HSP 90 (HSC82), Yeast 11
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 10
Z80244 Z80244 CHEMBL614335 MDA-MB-468 (Breast Adenocarcinoma) 9
ENPL_CANFA P41148 CHEMBL4748 Heat Shock Protein 90 Beta, Canine 7
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 7
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 5
HSP82_YEAST P02829 CHEMBL3536 Heat Shock Protein HSP 90 (HSP82), Yeast 4
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 3
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 3
Z50347 Z50347 CHEMBL361 Saccharomyces Cerevisiae 3
Z80434 Z80434 CHEMBL614883 RPTEC (Renal Proximal Tubule Epithelial Cells) 3
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 2
HS90A_MOUSE P07901 CHEMBL4197 Heat Shock Protein HSP 90-alpha, Mouse 2
Z103205 Z103205 CHEMBL1075390 A431 2
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 2
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 2
Z80895 Z80895 CHEMBL612256 NCI-H596 2
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 2
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
ENPL_HUMAN P14625 CHEMBL1075323 Endoplasmin, Human 1
HSP90_RABIT P11500 CHEMBL1667702 Heat Shock Protein HSP 90, Rabit 1
KCMA1_HUMAN Q12791 CHEMBL4304 Large Conductance Calcium-activated Potassium Channel Subfamily M Alpha Member 1 Isoform B, Human 1
KCMA1_RAT Q62976 CHEMBL5505 Calcium-activated Potassium Channel Subunit Alpha-1, Rat 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
SRC_RAT Q9WUD9 CHEMBL3014 Tyrosine-protein Kinase SRC, Rat 1
TRAP1_HUMAN Q12931 CHEMBL1075132 Heat Shock Protein 75 KDa, Mitochondrial, Human 1
Z103203 Z103203 CHEMBL1075388 A375 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80262 Z80262 CHEMBL614348 NCI-H1975 (Bronchoalveolar Carcinoma Cells) 1
Z80359 Z80359 CHEMBL614064 P19 1
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 1
Z80488 Z80488 CHEMBL614922 SK-MEL-5 (Melanoma Cells) 1
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 1
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 1
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 1
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 1
Z81186 Z81186 CHEMBL614097 LS174T (Colon Adencocarcinoma Cells) 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 1
Z81335 Z81335 CHEMBL612263 HCT-15 (Colon Adenocarcinoma Cells) 1

Most Common Rings