UCSF

Heat Shock Protein HSP 90-beta, Human (144 Compounds)

Swissprot:
HS90B_HUMAN
Stitch:
HS90B_HUMAN
UniProt:
P08238
ChEMBL:
CHEMBL4303
Reactome:
REACT_200624
REACT_200744
REACT_200775
REACT_160086
REACT_19236
REACT_75808
PDB:
1QZ2 (DOCK)
1UYM (DOCK)
3NMQ (DOCK)
3PRY (DOCK)
HSP90AB1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 144 24 7 20
Binding ≤ 1μM 102 17 7 16
Functional ≤ 10μM 76 15 4 8

Reactome Network (6)

Reactome ID Description Species
REACT_200624 Attenuation phase Homo sapiens
REACT_200744 HSF1 activation Homo sapiens
REACT_200775 HSF1-dependent transactivation Homo sapiens
REACT_160086 Regulation of actin dynamics for phagocytic cup formation Homo sapiens
REACT_19236 Sema3A PAK dependent Axon repulsion Homo sapiens
REACT_75808 The NLRP3 inflammasome Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 124

HSF1 activation

Uniprot Swissprot Chembl Description Number Shared
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 124

HSF1-dependent transactivation

Uniprot Swissprot Chembl Description Number Shared
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 124

Regulation of actin dynamics for phagocytic cup formation

Uniprot Swissprot Chembl Description Number Shared
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 124

Sema3A PAK dependent Axon repulsion

Uniprot Swissprot Chembl Description Number Shared
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 124

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
HS90B-1-E Heat Shock Protein HSP 90-beta (cluster #1 Of 2), Eukaryotic 75 8 7 5
HS90B-2-E Heat Shock Protein HSP 90-beta (cluster #2 Of 2), Eukaryotic 69 16 0 15
Uniprot Swissprot Chembl Description Number Shared
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 124
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 35
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 27
Z80244 Z80244 CHEMBL614335 MDA-MB-468 (Breast Adenocarcinoma) 10
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 10
ENPL_CANFA P41148 CHEMBL4748 Heat Shock Protein 90 Beta, Canine 7
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 7
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 5
Z80434 Z80434 CHEMBL614883 RPTEC (Renal Proximal Tubule Epithelial Cells) 3
HS90A_MOUSE P07901 CHEMBL4197 Heat Shock Protein HSP 90-alpha, Mouse 2
HSC82_YEAST P15108 CHEMBL4199 Heat Shock Protein HSP 90 (HSC82), Yeast 2
HSP82_YEAST P02829 CHEMBL3536 Heat Shock Protein HSP 90 (HSP82), Yeast 2
Z103205 Z103205 CHEMBL1075390 A431 2
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 2
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 2
Z80895 Z80895 CHEMBL612256 NCI-H596 2
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 2
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
ENPL_HUMAN P14625 CHEMBL1075323 Endoplasmin, Human 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
HSP90_RABIT P11500 CHEMBL1667702 Heat Shock Protein HSP 90, Rabit 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
SRC_RAT Q9WUD9 CHEMBL3014 Tyrosine-protein Kinase SRC, Rat 1
TRAP1_HUMAN Q12931 CHEMBL1075132 Heat Shock Protein 75 KDa, Mitochondrial, Human 1
Z103203 Z103203 CHEMBL1075388 A375 1
Z50347 Z50347 CHEMBL361 Saccharomyces Cerevisiae 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80262 Z80262 CHEMBL614348 NCI-H1975 (Bronchoalveolar Carcinoma Cells) 1
Z80291 Z80291 CHEMBL614181 MRC5 (Embryonic Lung Fibroblast Cells) 1
Z80359 Z80359 CHEMBL614064 P19 1
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 1
Z80488 Z80488 CHEMBL614922 SK-MEL-5 (Melanoma Cells) 1
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 1
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 1
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 1
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 1
Z81186 Z81186 CHEMBL614097 LS174T (Colon Adencocarcinoma Cells) 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 1
Z81335 Z81335 CHEMBL612263 HCT-15 (Colon Adenocarcinoma Cells) 1

Most Common Rings