UCSF

Estrogen Receptor Alpha, Human (1,669 Compounds)

Swissprot:
ESR1_HUMAN
Stitch:
ESR1_HUMAN
UniProt:
P03372
ChEMBL:
CHEMBL206
Reactome:
REACT_15525
REACT_116022
PDB:
1A52 (DOCK)
1AKF (DOCK)
1ERE (DOCK)
1ERR (DOCK)
1G50 (DOCK)
1GWQ (DOCK)
1GWR (DOCK)
1HCP (DOCK)
1HCQ (DOCK)
1L2I (DOCK)
1PCG (DOCK)
1QKT (DOCK)
1QKU (DOCK)
1R5K (DOCK)
1SJ0 (DOCK)
1UOM (DOCK)
1X7E (DOCK)
1X7R (DOCK)
1XP1 (DOCK)
1XP6 (DOCK)
1XP9 (DOCK)
1XPC (DOCK)
1XQC (DOCK)
1YIM (DOCK)
1YIN (DOCK)
1ZKY (DOCK)
2AYR (DOCK)
2B1V (DOCK)
2B1Z (DOCK)
2B23 (DOCK)
2BJ4 (DOCK)
2FAI (DOCK)
2G44 (DOCK)
2G5O (DOCK)
2I0J (DOCK)
2IOG (DOCK)
2IOK (DOCK)
2JF9 (DOCK)
2JFA (DOCK)
2LLO (DOCK)
2LLQ (DOCK)
2OCF (DOCK)
2OUZ (DOCK)
2P15 (DOCK)
2POG (DOCK)
2Q6J (DOCK)
2Q70 (DOCK)
2QA6 (DOCK)
2QA8 (DOCK)
2QAB (DOCK)
2QE4 (DOCK)
2QGT (DOCK)
2QGW (DOCK)
2QH6 (DOCK)
2QR9 (DOCK)
2QSE (DOCK)
2QXM (DOCK)
2QXS (DOCK)
2QZO (DOCK)
2R6W (DOCK)
2R6Y (DOCK)
2YAT (DOCK)
2YJA (DOCK)
3CBM (DOCK)
3CBO (DOCK)
3CBP (DOCK)
3DT3 (DOCK)
3ERD (DOCK)
3ERT (DOCK)
3HLV (DOCK)
3HM1 (DOCK)
3L03 (DOCK)
3OS8 (DOCK)
3OS9 (DOCK)
3OSA (DOCK)
3Q95 (DOCK)
3Q97 (DOCK)
4AA6 (DOCK)
ESR1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,669 74 54 67
Binding ≤ 1μM 1,296 54 42 61
Functional ≤ 10μM 781 60 28 34

Reactome Network (2)

Reactome ID Description Species
REACT_15525 Nuclear Receptor transcription pathway Homo sapiens
REACT_116022 Nuclear signaling by ERBB4 Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 144
ERR1_HUMAN P11474 CHEMBL3429 Estrogen-related Receptor Alpha, Human 9
ERR2_HUMAN O95718 CHEMBL3751 Estrogen-related Receptor Beta, Human 9
ERR3_HUMAN P62508 CHEMBL4245 Estrogen-related Receptor Gamma, Human 13
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1812
PRGR_HUMAN P06401 CHEMBL208 Progesterone Receptor, Human 52
THA_HUMAN P10827 CHEMBL1860 Thyroid Hormone Receptor Alpha, Human 1

Nuclear signaling by ERBB4

Uniprot Swissprot Chembl Description Number Shared
PRGR_HUMAN P06401 CHEMBL208 Progesterone Receptor, Human 52
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ESR1_BOVIN P49884 CHEMBL2930 Estrogen Receptor Alpha, Bovin 29 2 1 1
ESR1_MOUSE P19785 CHEMBL3065 Estrogen Receptor Alpha, Mouse 10 5 2 2
ESR1_RAT P06211 CHEMBL2724 Estrogen Receptor Alpha, Rat 84 14 11 11
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1,658 73 50 63

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
ESR1-1-E Estrogen Receptor Alpha (cluster #1 Of 5), Eukaryotic 1,489 63 46 66
ESR1-2-E Estrogen Receptor Alpha (cluster #2 Of 5), Eukaryotic 118 14 11 7
ESR1-3-E Estrogen Receptor Alpha (cluster #3 Of 5), Eukaryotic 39 3 1 1
ESR1-4-E Estrogen Receptor Alpha (cluster #4 Of 5), Eukaryotic 17 0 0 0
ESR1-5-E Estrogen Receptor Alpha (cluster #5 Of 5), Eukaryotic 84 5 5 5
Uniprot Swissprot Chembl Description Number Shared
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1811
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 142
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 134
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 51
PRGR_HUMAN P06401 CHEMBL208 Progesterone Receptor, Human 50
ESR2_MOUSE O08537 CHEMBL2995 Estrogen Receptor Beta, Mouse 37
MCR_HUMAN P08235 CHEMBL1994 Mineralocorticoid Receptor, Human 37
Z81068 Z81068 CHEMBL614649 Ishikawa (Uterine Carcinoma Cells) 34
Z80296 Z80296 CHEMBL614185 MVLN 32
ESR1_BOVIN P49884 CHEMBL2930 Estrogen Receptor Alpha, Bovin 29
ESR2_RAT Q62986 CHEMBL3021 Estrogen Receptor Beta, Rat 27
ESR1_RAT P06211 CHEMBL2724 Estrogen Receptor Alpha, Rat 24
ERR3_HUMAN P62508 CHEMBL4245 Estrogen-related Receptor Gamma, Human 12
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 12
Z80226 Z80226 CHEMBL614323 MCF7-2A 11
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 11
ESR1_MOUSE P19785 CHEMBL3065 Estrogen Receptor Alpha, Mouse 9
Z80712 Z80712 CHEMBL614361 T47D (Breast Carcinoma Cells) 9
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 9
ERR1_HUMAN P11474 CHEMBL3429 Estrogen-related Receptor Alpha, Human 8
ERR2_HUMAN O95718 CHEMBL3751 Estrogen-related Receptor Beta, Human 8
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 7
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 6
AHR_RABIT O02747 CHEMBL4725 Aryl Hydrocarbon Receptor, Rabit 5
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 5
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 3
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 3
HS90A_HUMAN P07900 CHEMBL3880 Heat Shock Protein HSP 90-alpha, Human 3
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 3
RASH_HUMAN P01112 CHEMBL2167 Transforming Protein P21/H-Ras-1, Human 3
Z100267 Z100267 CHEMBL612409 Anti-estrogen Binding Site (AEBS) 3
Z80110 Z80110 CHEMBL613507 CV-1 (Kidney Cells) 3
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 2
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 2
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 2
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 2
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 2
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 2
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 2
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 2
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 2
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 2
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 2
O77823_PIG O77823 CHEMBL3333 Phosphodiesterase 4A, Pig 2
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 2
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 2
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 2
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 2
PLD1_HUMAN Q13393 CHEMBL2536 Phospholipase D1, Human 2
PLD2_HUMAN O14939 CHEMBL2734 Phospholipase D2, Human 2
SC5A2_HUMAN P31639 CHEMBL3884 Sodium/glucose Cotransporter 2, Human 2
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 2
TYSY_HUMAN P04818 CHEMBL1952 Thymidylate Synthase, Human 2
Z80030 Z80030 CHEMBL614520 ANN-1 2
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 2
Z80561 Z80561 CHEMBL615023 U2OS (Osteosarcoma Cells) 2
Z80608 Z80608 CHEMBL614393 ZR-75-1 (Breast Carcinoma Cells) 2
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 1
ADCYA_HUMAN Q96PN6 CHEMBL5854 Adenylate Cyclase Type 10, Human 1
ALDH2_HUMAN P05091 CHEMBL1935 Aldehyde Dehydrogenase, Human 1
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
ANDR_MOUSE P19091 CHEMBL3056 Androgen Receptor, Mouse 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
ENV_MMTVG P03374 CHEMBL5825 Envelope Glycoprotein Gp70, Mmtvg 1
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 1
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
GCR_MOUSE P06537 CHEMBL3144 Glucocorticoid Receptor, Mouse 1
GCR_RAT P06536 CHEMBL3368 Glucocorticoid Receptor, Rat 1
GPBAR_HUMAN Q8TDU6 CHEMBL5409 G-protein Coupled Bile Acid Receptor 1, Human 1
GPER_HUMAN Q99527 CHEMBL5872 G-protein Coupled Estrogen Receptor 1, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
HS90B_HUMAN P08238 CHEMBL4303 Heat Shock Protein HSP 90-beta, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
MCR_RAT P22199 CHEMBL3507 Mineralocorticoid Receptor, Rat 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MGA_HUMAN O43451 CHEMBL2074 Maltase-glucoamylase, Human 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
NQO2_HUMAN P16083 CHEMBL3959 Quinone Reductase 2, Human 1
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1
NR1H4_MOUSE Q60641 CHEMBL5343 Bile Acid Receptor, Mouse 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 1
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 1
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 1
PRGR_CHICK P07812 CHEMBL3304 Progesterone Receptor, Chick 1
PRGR_RAT Q63449 CHEMBL2596 Progesterone Receptor, Rat 1
Q8AWE3_CHICK Q8AWE3 CHEMBL2669 Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
SHBG_HUMAN P04278 CHEMBL3305 Testis-specific Androgen-binding Protein, Human 1
STS_HUMAN P08842 CHEMBL3559 Steryl-sulfatase Precursor, Human 1
THA_HUMAN P10827 CHEMBL1860 Thyroid Hormone Receptor Alpha, Human 1
TOP1_HUMAN P11387 CHEMBL1781 DNA Topoisomerase I, Human 1
TYRO_AGABI O42713 CHEMBL3318 Tyrosinase, Agabi 1
VP16_HHV11 P06492 CHEMBL4218 Alpha Trans-inducing Protein (VP16), Hhv11 1
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 1
Z103205 Z103205 CHEMBL1075390 A431 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 1
Z50420 Z50420 CHEMBL612851 Trypanosoma Brucei Brucei 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z80005 Z80005 CHEMBL614077 3T3 (Fibroblast Cells) 1
Z80037 Z80037 CHEMBL614065 Balb/MK 1
Z80132 Z80132 CHEMBL614293 EL4 (Thymoma Cells) 1
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 1
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 1
Z80227 Z80227 CHEMBL614324 MCF7-ADR (Breast Carcinoma Cells) 1
Z80231 Z80231 CHEMBL614328 MCF7S (Breast Carcinoma Cells) 1
Z80262 Z80262 CHEMBL614348 NCI-H1975 (Bronchoalveolar Carcinoma Cells) 1
Z80359 Z80359 CHEMBL614064 P19 1
Z80491 Z80491 CHEMBL614163 SK-N-MC (Neuroepithelioma Cells) 1
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 1
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 1
Z81057 Z81057 CHEMBL613979 HUVEC (Umbilical Vein Endothelial Cells) 1
Z81186 Z81186 CHEMBL614097 LS174T (Colon Adencocarcinoma Cells) 1
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 1
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 1
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 1

Most Common Rings