ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (198)
Reactome (1)
Related By:
Pathway (2)
Organism (1)
Gene (0)
Org. Clust. (0)
ChEMBL (70)
Rings (10)

Phosphodiesterase 1C, Human (198 Compounds)

Swissprot:: PDE1C_HUMAN
Stitch:: PDE1C_HUMAN
UniProt:: Q14123
ChEMBL:: CHEMBL4619
Reactome:: REACT_15408
PDB:: 1LXS (DOCK); PDE1C

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	198	21	8	8
Binding ≤ 1μM	81	7	2	2
Functional ≤ 10μM	7	1	1	1

Reactome ID	Description	Species
REACT_15408	Cam-PDE 1 activation	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
PDE1A_HUMAN	P54750	CHEMBL3421	Phosphodiesterase 1A, Human	185
PDE1B_HUMAN	Q01064	CHEMBL4425	Phosphodiesterase 1B, Human	185

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PDE1C_RAT	Q63421	CHEMBL2651	Phosphodiesterase 1C, Rat	20	6	2	2

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
PDE1A_HUMAN	P54750	CHEMBL3421	Phosphodiesterase 1A, Human	185
PDE1B_HUMAN	Q01064	CHEMBL4425	Phosphodiesterase 1B, Human	185
PDE5A_HUMAN	O76074	CHEMBL1827	Phosphodiesterase 5A, Human	103
PDE4D_HUMAN	Q08499	CHEMBL288	Phosphodiesterase 4D, Human	52
PDE3A_HUMAN	Q14432	CHEMBL241	Phosphodiesterase 3A, Human	44
PDE3B_HUMAN	Q13370	CHEMBL290	Phosphodiesterase 3B, Human	37
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	30
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	30
PDE4C_HUMAN	Q08493	CHEMBL291	Phosphodiesterase 4C, Human	30
PDE7A_HUMAN	Q13946	CHEMBL3012	Phosphodiesterase 7A, Human	28
O77823_PIG	O77823	CHEMBL3333	Phosphodiesterase 4A, Pig	27
PDE9A_HUMAN	O76083	CHEMBL3535	Phosphodiesterase 9A, Human	17
PDE1A_BOVIN	P14100	CHEMBL3774	Phosphodiesterase 1A, Bovin	8
Q864F1_PIG	Q864F1	CHEMBL3634	Phosphodiesterase 5, Pig	8
PDE1B_RAT	Q01066	CHEMBL3665	Phosphodiesterase 1B, Rat	7
PDE1B_BOVIN	Q01061	CHEMBL2650	Phosphodiesterase 1B, Bovin	6
PDE2A_HUMAN	O00408	CHEMBL2652	Phosphodiesterase 2A, Human	5
PDE1C_RAT	Q63421	CHEMBL2651	Phosphodiesterase 1C, Rat	4
Q9EPR9_RAT	Q9EPR9	CHEMBL2740	Phosphodiesterase 1A, Rat	4
CNCG_HUMAN	Q13956	CHEMBL2341	Phosphodiesterase 6H, Human	3
CNRG_HUMAN	P18545	CHEMBL2415	Phosphodiesterase 6G, Human	3
E1BN64_BOVIN	E1BN64	CHEMBL5129	Phosphodiesterase 3B, Bovin	3
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	3
PDE10_HUMAN	Q9Y233	CHEMBL4409	Phosphodiesterase 10A, Human	3
PDE5A_BOVIN	Q28156	CHEMBL3478	Phosphodiesterase 5A, Bovin	3
PDE6A_HUMAN	P16499	CHEMBL3878	Phosphodiesterase 6A, Human	3
PDE6B_HUMAN	P35913	CHEMBL3659	Phosphodiesterase 6B, Human	3
PDE6C_HUMAN	P51160	CHEMBL3977	Phosphodiesterase 6C, Human	3
PDE6D_HUMAN	O43924	CHEMBL3860	Phosphodiesterase 6D, Human	3
PDE7B_HUMAN	Q9NP56	CHEMBL4716	Phosphodiesterase 7B, Human	3
CNCG_BOVIN	P22571	CHEMBL4606	Phosphodiesterase 6H, Bovin	2
CNRG_BOVIN	P04972	CHEMBL5111	Phosphodiesterase 6G, Bovin	2
ESR1_HUMAN	P03372	CHEMBL206	Estrogen Receptor Alpha, Human	2
ESR2_HUMAN	Q92731	CHEMBL242	Estrogen Receptor Beta, Human	2
PDE11_HUMAN	Q9HCR9	CHEMBL2717	Phosphodiesterase 11A, Human	2
PDE4A_RAT	P54748	CHEMBL4964	Phosphodiesterase 4A, Rat	2
PDE4B_RAT	P14646	CHEMBL3382	Phosphodiesterase 4B, Rat	2
PDE4C_RAT	P14644	CHEMBL4562	Phosphodiesterase 4C, Rat	2
PDE4D_RAT	P14270	CHEMBL2712	Phosphodiesterase 4D, Rat	2
PDE6A_BOVIN	P11541	CHEMBL3741	Phosphodiesterase 6A, Bovin	2
PDE6B_BOVIN	P23439	CHEMBL2713	Phosphodiesterase 6B, Bovin	2
PDE6C_BOVIN	P16586	CHEMBL3479	Phosphodiesterase 6C, Bovin	2
PDE6D_BOVIN	Q95142	CHEMBL5110	Phosphodiesterase 6D, Bovin	2
PDE7A_RAT	O08593	CHEMBL3450	Phosphodiesterase 7A, Rat	2
Q9XSW7_PIG	Q9XSW7	CHEMBL3061	Phosphodiesterase 3A, Pig	2
AA1R_BOVIN	P28190	CHEMBL4975	Adenosine A1 Receptor, Bovin	1
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	1
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	1
AA2AR_CAVPO	P46616	CHEMBL2605	Adenosine A2a Receptor, Guinea Pig	1
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	1
AA2BR_RAT	P29276	CHEMBL2592	Adenosine A2b Receptor, Rat	1
AA3R_RAT	P28647	CHEMBL3360	Adenosine A3 Receptor, Rat	1
EBP_HUMAN	Q15125	CHEMBL4931	3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human	1
ERG2_YEAST	P32352	CHEMBL3224	C-8 Sterol Isomerase, Yeast	1
MDR1_HUMAN	P08183	CHEMBL4302	P-glycoprotein 1, Human	1
PDE10_RAT	Q9QYJ6	CHEMBL6140	CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat	1
PDE2A_BOVIN	P14099	CHEMBL3477	Phosphodiesterase 2A, Bovin	1
PDE5A_RAT	O54735	CHEMBL4567	Phosphodiesterase 5A, Rat	1
Q8AWE3_CHICK	Q8AWE3	CHEMBL2669	Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick	1
Q8VIE4_RAT	Q8VIE4	CHEMBL3386	Phosphodiesterase 7B, Rat	1
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	1
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	1
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	1
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	1
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	1
Z100267	Z100267	CHEMBL612409	Anti-estrogen Binding Site (AEBS)	1
Z50590	Z50590	CHEMBL613488	Sus Scrofa	1
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	1
Z80224	Z80224	CHEMBL387	MCF7 (Breast Carcinoma Cells)	1
Z81068	Z81068	CHEMBL614649	Ishikawa (Uterine Carcinoma Cells)	1