UCSF

Adenosine A2a Receptor, Rat (2,846 Compounds)

Swissprot:
AA2AR_RAT
Stitch:
AA2AR_RAT
UniProt:
P30543
ChEMBL:
CHEMBL302
Reactome:
REACT_245507
REACT_246814
REACT_256363
PDB:
Adora2a

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,846 130 40 27
Binding ≤ 1μM 1,981 67 17 15
Functional ≤ 10μM 244 23 7 3

Reactome Network (3)

Reactome ID Description Species
REACT_245507 Adenosine P1 receptors Rattus norvegicus
REACT_246814 G alpha (s) signalling events Rattus norvegicus
REACT_256363 NGF-independant TRKA activation Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 2301

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 22
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 5
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 18 9 3 3
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2,605 153 29 23
AA2AR_MOUSE Q60613 CHEMBL2115 Adenosine A2a Receptor, Mouse 5 2 0 1

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
AA2AR-1-E Adenosine A2a Receptor (cluster #1 Of 4), Eukaryotic 4,969 188 36 30
AA2AR-2-E Adenosine A2a Receptor (cluster #2 Of 4), Eukaryotic 59 29 5 4
AA2AR-3-E Adenosine A2a Receptor (cluster #3 Of 4), Eukaryotic 121 25 12 4
AA2AR-4-E Adenosine A2a Receptor (cluster #4 Of 4), Eukaryotic 33 7 3 3
Uniprot Swissprot Chembl Description Number Shared
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 2293
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1341
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 382
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 372
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 303
AA3R_RAT P28647 CHEMBL3360 Adenosine A3 Receptor, Rat 288
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 282
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 60
OXGR1_RAT Q6Y1R5 CHEMBL2325 G Protein-coupled Receptor 80, Rat 23
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 22
AA1R_CHICK P49892 CHEMBL2114 Adenosine A1 Receptor, Chick 18
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 16
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 15
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 14
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 9
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 9
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 9
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 9
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 9
SAHH_HUMAN P23526 CHEMBL2664 Adenosylhomocysteinase, Human 7
Z100273 Z100273 CHEMBL612413 P3 Purinoceptor 7
ADA_BOVIN P56658 CHEMBL2966 Adenosine Deaminase, Bovin 6
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 6
CAC1D_RAT P27732 CHEMBL4132 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat 6
Z50512 Z50512 CHEMBL369 Cavia Porcellus 6
AA1R_MOUSE Q60612 CHEMBL3688 Adenosine A1 Receptor, Mouse 5
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 5
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 5
SAHH_MOUSE P50247 CHEMBL2389 Adenosylhomocysteinase, Mouse 4
AA2AR_MOUSE Q60613 CHEMBL2115 Adenosine A2a Receptor, Mouse 3
AA3R_MOUSE Q61618 CHEMBL1075269 Adenosine Receptor A3, Mouse 3
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 3
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 3
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 3
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 3
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 3
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 3
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 3
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 3
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 3
S29A1_HUMAN Q99808 CHEMBL1997 Equilibrative Nucleoside Transporter 1, Human 3
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 3
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 3
Z50588 Z50588 CHEMBL373 Canis Familiaris 3
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 2
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 2
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 2
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 2
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 2
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 2
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 2
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 2
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 2
Q4VQ11_PIG Q4VQ11 CHEMBL1075029 A1 Adenosine Receptor, Pig 2
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z50587 Z50587 CHEMBL372 Homo Sapiens 2
Z80945 Z80945 CHEMBL614735 HEp-2 (Laryngeal Carcinoma Cells) 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA2BR_MOUSE Q60614 CHEMBL2237 Adenosine A2b Receptor, Mouse 1
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 1
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 1
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 1
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 1
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 1
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 1
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 1
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 1
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 1
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 1
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 1
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 1
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 1
ADA_HUMAN P00813 CHEMBL1910 Adenosine Deaminase, Human 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 1
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 1
ADK_TOXGO Q9TVW2 CHEMBL2982 Adenosine Kinase, Toxgo 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
AOFB_MOUSE Q8BW75 CHEMBL3050 Monoamine Oxidase B, Mouse 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CAC1A_RAT P54282 CHEMBL4417 Voltage-gated P/Q-type Calcium Channel Alpha-1A Subunit, Rat 1
CAC1B_RAT Q02294 CHEMBL5107 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Rat 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1C_RABIT P15381 CHEMBL2830 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rabit 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1E_RAT Q07652 CHEMBL4115 Voltage-gated R-type Calcium Channel Alpha-1E Subunit, Rat 1
CAC1G_RAT O54898 CHEMBL4257 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Rat 1
CAC1H_RAT Q9EQ60 CHEMBL5134 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Rat 1
CAC1I_RAT Q9Z0Y8 CHEMBL5459 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Rat 1
CAC1S_RAT Q02485 CHEMBL4108 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Rat 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
GBRB1_HUMAN P18505 CHEMBL4558 GABA Receptor Beta-1 Subunit, Human 1
GBRB2_HUMAN P47870 CHEMBL1920 GABA Receptor Beta-2 Subunit, Human 1
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 1
GBRD_HUMAN O14764 CHEMBL3591 GABA Receptor Delta Subunit, Human 1
GBRE_HUMAN P78334 CHEMBL4635 GABA Receptor Epsilon Subunit, Human 1
GBRG1_HUMAN Q8N1C3 CHEMBL4044 GABA Receptor Gamma-1 Subunit, Human 1
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 1
GBRG3_HUMAN Q99928 CHEMBL2739 GABA Receptor Gamma-3 Subunit, Human 1
GBRP_HUMAN O00591 CHEMBL3506 GABA Receptor Pi Subunit, Human 1
GBRT_HUMAN Q9UN88 CHEMBL2843 GABA Receptor Theta Subunit, Human 1
GRP78_HUMAN P11021 CHEMBL1781865 78 KDa Glucose-regulated Protein, Human 1
KCNA5_HUMAN P22460 CHEMBL4306 Voltage-gated Potassium Channel Subunit Kv1.5, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
P4K2A_HUMAN Q9BTU6 CHEMBL2251 PI4-kinase Type II, Human 1
P4K2B_HUMAN Q8TCG2 CHEMBL3220 PI4-kinase Type II Beta, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PDE1A_BOVIN P14100 CHEMBL3774 Phosphodiesterase 1A, Bovin 1
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 1
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 1
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 1
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 1
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 1
PDE1C_RAT Q63421 CHEMBL2651 Phosphodiesterase 1C, Rat 1
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 1
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 1
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 1
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 1
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 1
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 1
PDE7B_HUMAN Q9NP56 CHEMBL4716 Phosphodiesterase 7B, Human 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
PI4KA_HUMAN P42356 CHEMBL3667 PI4-kinase Alpha Subunit, Human 1
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
Q9EPR9_RAT Q9EPR9 CHEMBL2740 Phosphodiesterase 1A, Rat 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
S29A1_RAT O54698 CHEMBL4604 Equilibrative Nucleoside Transporter 1, Rat 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1
Z102306 Z102306 CHEMBL613606 Aorta 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 1
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 1

Most Common Rings