UCSF

Arachidonate 12-lipoxygenase, Human (87 Compounds)

Swissprot:
LOX12_HUMAN
Stitch:
LOX12_HUMAN
UniProt:
P18054
ChEMBL:
CHEMBL3687
Reactome:
REACT_150201
REACT_150292
REACT_150320
PDB:
2ABU (DOCK)
3D3L (DOCK)
ALOX12

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 87 23 11 5
Binding ≤ 1μM 31 14 7 4
Functional ≤ 10μM 2 0 0 0

Reactome Network (3)

Reactome ID Description Species
REACT_150201 Synthesis of 12-eicosatetraenoic acid derivatives Homo sapiens
REACT_150292 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Homo sapiens
REACT_150320 Synthesis of Lipoxins (LX) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 38

Synthesis of Lipoxins (LX)

Uniprot Swissprot Chembl Description Number Shared
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 9
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
LOX12_MOUSE P39655 CHEMBL3225 Arachidonate 12-lipoxygenase, Mouse 3 0 0 0
LOX12_PIG P16469 CHEMBL2381 Arachidonate 12-lipoxygenase, Pig 15 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 105 24 13 5
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 952 85 36 16

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
LOX12-1-E Arachidonate 12-lipoxygenase (cluster #1 Of 4), Eukaryotic 27 6 5 2
LOX12-2-E Arachidonate 12-lipoxygenase (cluster #2 Of 4), Eukaryotic 70 17 6 4
LOX12-3-E Arachidonate 12-lipoxygenase (cluster #3 Of 4), Eukaryotic 9 1 2 0
LOX12-4-E Arachidonate 12-lipoxygenase (cluster #4 Of 4), Eukaryotic 1 1 0 0
Uniprot Swissprot Chembl Description Number Shared
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 38
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 9
LOX1_SOYBN P08170 CHEMBL4586 Seed Lipoxygenase-1, Soybn 9
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 9
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 5
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 4
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 3
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 3
LT4R1_HUMAN Q15722 CHEMBL3911 Leukotriene B4 Receptor 1, Human 3
Q9BEG3_BOVIN Q9BEG3 CHEMBL2980 Arachidonate 5-lipoxygenase, Bovin 3
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 3
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 2
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 2
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 2
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 2
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CETP_HUMAN P11597 CHEMBL3572 Cholesteryl Ester Transfer Protein, Human 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
FAS_HUMAN P49327 CHEMBL4158 Fatty Acid Synthase, Human 1
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
KD4DL_HUMAN B2RXH2 CHEMBL1293226 Lysine-specific Demethylase 4D-like, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LX12L_RAT Q02759 CHEMBL2741 Arachidonate 12-lipoxygenase, Rat 1
LX15B_HUMAN O15296 CHEMBL2457 Arachidonate 15-lipoxygenase, Type II, Human 1
LX15B_RAT Q8K4F2 CHEMBL3289 Arachidonate 15-lipoxygenase, Type II, Rat 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 1
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PUR9_HUMAN P31939 CHEMBL2518 AICAR Transformylase, Human 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1