UCSF

PI3-kinase P85-alpha Subunit, Human (52 Compounds)

Swissprot:
P85A_HUMAN
Stitch:
P85A_HUMAN
UniProt:
P27986
ChEMBL:
CHEMBL2506
Reactome:
REACT_118700
REACT_19358
REACT_147727
REACT_19344
REACT_147814
REACT_17025
REACT_12555
REACT_18407
REACT_18283
REACT_12578
REACT_23847
REACT_1695
REACT_23891
REACT_23837
REACT_115529
REACT_23832
REACT_21270
REACT_976
REACT_116008
REACT_115961
REACT_12464
REACT_75829
REACT_23787
REACT_163769
REACT_160158
REACT_115852
REACT_121398
REACT_121141
REACT_111040
REACT_121025
REACT_12621
REACT_228166
PDB:
1A0N (DOCK)
1AZG (DOCK)
1H9O (DOCK)
1PBW (DOCK)
1PHT (DOCK)
1PIC (DOCK)
1PKS (DOCK)
1PKT (DOCK)
2IUG (DOCK)
2IUH (DOCK)
2IUI (DOCK)
2RD0 (DOCK)
2V1Y (DOCK)
3HHM (DOCK)
3HIZ (DOCK)
3I5R (DOCK)
3I5S (DOCK)
4A55 (DOCK)
PIK3R1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 52 7 4 4
Binding ≤ 1μM 32 4 1 2
Functional ≤ 10μM 0 0 0 0

Reactome Network (32)

Reactome ID Description Species
REACT_118700 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge Homo sapiens
REACT_19358 CD28 dependent PI3K/Akt signaling Homo sapiens
REACT_147727 Constitutive PI3K/AKT Signaling in Cancer Homo sapiens
REACT_19344 Costimulation by the CD28 family Homo sapiens
REACT_147814 DAP12 signaling Homo sapiens
REACT_17025 Downstream signal transduction Homo sapiens
REACT_12555 Downstream TCR signaling Homo sapiens
REACT_18407 G alpha (12/13) signalling events Homo sapiens
REACT_18283 G alpha (q) signalling events Homo sapiens
REACT_12578 GAB1 signalosome Homo sapiens
REACT_23847 GP1b-IX-V activation signalling Homo sapiens
REACT_1695 GPVI-mediated activation cascade Homo sapiens
REACT_23891 Interleukin receptor SHC signaling Homo sapiens
REACT_23837 Interleukin-3, 5 and GM-CSF signaling Homo sapiens
REACT_115529 Interleukin-7 signaling Homo sapiens
REACT_23832 Nephrin interactions Homo sapiens
REACT_21270 PI-3K cascade Homo sapiens
REACT_976 PI3K Cascade Homo sapiens
REACT_116008 PI3K events in ERBB2 signaling Homo sapiens
REACT_115961 PI3K events in ERBB4 signaling Homo sapiens
REACT_12464 PI3K/AKT activation Homo sapiens
REACT_75829 PIP3 activates AKT signaling Homo sapiens
REACT_23787 Regulation of signaling by CBL Homo sapiens
REACT_163769 Role of LAT2/NTAL/LAB on calcium mobilization Homo sapiens
REACT_160158 Role of phospholipids in phagocytosis Homo sapiens
REACT_115852 Signaling by constitutively active EGFR Homo sapiens
REACT_121398 Signaling by FGFR mutants Homo sapiens
REACT_121141 Signaling by FGFR1 fusion mutants Homo sapiens
REACT_111040 Signaling by SCF-KIT Homo sapiens
REACT_121025 Synthesis of PIPs at the plasma membrane Homo sapiens
REACT_12621 Tie2 Signaling Homo sapiens
REACT_228166 VEGFA-VEGFR2 Pathway Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 8
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 3

CD28 dependent PI3K/Akt signaling

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 2
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 2
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 2
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 6
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 4
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

Constitutive PI3K/AKT Signaling in Cancer

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 2
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 2
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 6
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 4
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 8

Costimulation by the CD28 family

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

DAP12 signaling

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 6
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 3

Downstream signal transduction

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

Downstream TCR signaling

Uniprot Swissprot Chembl Description Number Shared
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 6
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5

G alpha (12/13) signalling events

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

G alpha (q) signalling events

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

GAB1 signalosome

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

GPVI-mediated activation cascade

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 2
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 2
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 2
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 6
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 8
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 3

Interleukin receptor SHC signaling

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 8

Interleukin-3, 5 and GM-CSF signaling

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 8

Interleukin-7 signaling

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37

Nephrin interactions

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5

PI-3K cascade

Uniprot Swissprot Chembl Description Number Shared
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

PI3K Cascade

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3C3_HUMAN Q8NEB9 CHEMBL1075165 Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human 3
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5

PI3K events in ERBB2 signaling

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

PI3K events in ERBB4 signaling

Uniprot Swissprot Chembl Description Number Shared
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

PI3K/AKT activation

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5

PIP3 activates AKT signaling

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 2
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 2
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 6
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 4
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 8

Regulation of signaling by CBL

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 8

Role of LAT2/NTAL/LAB on calcium mobilization

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5

Role of phospholipids in phagocytosis

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 3

Signaling by constitutively active EGFR

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

Signaling by FGFR mutants

Uniprot Swissprot Chembl Description Number Shared
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

Signaling by FGFR1 fusion mutants

Uniprot Swissprot Chembl Description Number Shared
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

Signaling by SCF-KIT

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 6
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18

Synthesis of PIPs at the plasma membrane

Uniprot Swissprot Chembl Description Number Shared
P3C2A_HUMAN O00443 CHEMBL1075102 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human 3
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 4
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 8
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 8

Tie2 Signaling

Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5

VEGFA-VEGFR2 Pathway

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
P85A-1-E PI3-kinase P85-alpha Subunit (cluster #1 Of 2), Eukaryotic 11 0 0 0
P85A-2-E PI3-kinase P85-alpha Subunit (cluster #2 Of 2), Eukaryotic 41 7 4 4
Uniprot Swissprot Chembl Description Number Shared
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 37
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 18
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 8
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 8
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 7
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 6
PK3CA_BOVIN P32871 CHEMBL2498 PI3-kinase P110-alpha Subunit, Bovin 5
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
GRB2_HUMAN P62993 CHEMBL3663 Growth Factor Receptor-bound Protein 2, Human 4
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 4
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 4
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 4
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 3
MTOR_MOUSE Q9JLN9 CHEMBL1255165 Serine/threonine-protein Kinase MTOR, Mouse 3
P3C2A_HUMAN O00443 CHEMBL1075102 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human 3
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 3
PK3C3_HUMAN Q8NEB9 CHEMBL1075165 Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human 3
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 3
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 2
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 2
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 2
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 2
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 2
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 1
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
MYLK_CHICK P11799 CHEMBL3062 Myosin Light Chain Kinase, Smooth Muscle, Chick 1
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PK3CA_MOUSE P42337 CHEMBL2499 PI3-kinase P110-alpha Subunit, Mouse 1
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 1

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