UCSF

PI3-kinase P110-alpha Subunit, Bovin (33 Compounds)

Swissprot:
PK3CA_BOVIN
Stitch:
PK3CA_BOVIN
UniProt:
P32871
ChEMBL:
CHEMBL2498
Reactome:
REACT_217559
REACT_215895
REACT_213843
REACT_214988
REACT_212750
REACT_205423
REACT_205384
REACT_209521
REACT_222082
REACT_219098
REACT_223657
REACT_211267
REACT_211504
REACT_204467
REACT_209911
REACT_219416
REACT_222492
REACT_225332
REACT_208171
REACT_218512
REACT_224097
REACT_215783
REACT_203011
REACT_226907
REACT_227241
REACT_204114
REACT_227888
REACT_204566
REACT_246299
PDB:
2V1Y (DOCK)
PIK3CA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 33 6 1 1
Binding ≤ 1μM 29 6 1 1

Reactome Network (29)

Reactome ID Description Species
REACT_217559 CD28 dependent PI3K/Akt signaling Bos taurus
REACT_215895 Constitutive PI3K/AKT Signaling in Cancer Bos taurus
REACT_213843 Costimulation by the CD28 family Bos taurus
REACT_214988 DAP12 signaling Bos taurus
REACT_212750 Downstream signal transduction Bos taurus
REACT_205423 Downstream TCR signaling Bos taurus
REACT_205384 G alpha (12/13) signalling events Bos taurus
REACT_209521 G alpha (q) signalling events Bos taurus
REACT_222082 GAB1 signalosome Bos taurus
REACT_219098 GPVI-mediated activation cascade Bos taurus
REACT_223657 Interleukin receptor SHC signaling Bos taurus
REACT_211267 Interleukin-3, 5 and GM-CSF signaling Bos taurus
REACT_211504 Nephrin interactions Bos taurus
REACT_204467 PI-3K cascade Bos taurus
REACT_209911 PI3K Cascade Bos taurus
REACT_219416 PI3K events in ERBB2 signaling Bos taurus
REACT_222492 PI3K events in ERBB4 signaling Bos taurus
REACT_225332 PI3K/AKT activation Bos taurus
REACT_208171 PIP3 activates AKT signaling Bos taurus
REACT_218512 Regulation of signaling by CBL Bos taurus
REACT_224097 Role of LAT2/NTAL/LAB on calcium mobilization Bos taurus
REACT_215783 Role of phospholipids in phagocytosis Bos taurus
REACT_203011 Signaling by constitutively active EGFR Bos taurus
REACT_226907 Signaling by FGFR mutants Bos taurus
REACT_227241 Signaling by FGFR1 fusion mutants Bos taurus
REACT_204114 Signaling by SCF-KIT Bos taurus
REACT_227888 Synthesis of PIPs at the plasma membrane Bos taurus
REACT_204566 Tie2 Signaling Bos taurus
REACT_246299 VEGFA-VEGFR2 Pathway Bos taurus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1,234 42 4 9
PK3CA_MOUSE P42337 CHEMBL2499 PI3-kinase P110-alpha Subunit, Mouse 3 3 2 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PK3CA-1-E PI3-kinase P110-alpha Subunit (cluster #1 Of 2), Eukaryotic 12 0 0 0
PK3CA-2-E PI3-kinase P110-alpha Subunit (cluster #2 Of 2), Eukaryotic 1,257 47 5 9
Uniprot Swissprot Chembl Description Number Shared
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 5
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 5
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 4
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 4
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 2
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 2
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 2
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 2
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 2
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 2
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
DAPK1_HUMAN P53355 CHEMBL2558 Death-associated Protein Kinase 1, Human 1
DAPK2_HUMAN Q9UIK4 CHEMBL3123 Death-associated Protein Kinase 2, Human 1
DAPK3_HUMAN O43293 CHEMBL2468 Death-associated Protein Kinase 3, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 1
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 1
KCC2A_MOUSE P11798 CHEMBL3347 CaM Kinase II Alpha, Mouse 1
KCC2B_MOUSE P28652 CHEMBL4735 CaM Kinase II Beta, Mouse 1
KCC2G_MOUSE Q923T9 CHEMBL4456 CaM Kinase II Gamma, Mouse 1
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PK3CA_MOUSE P42337 CHEMBL2499 PI3-kinase P110-alpha Subunit, Mouse 1
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 1
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 1
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 1
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 1