UCSF

Phospholipase C-gamma-2, Human (22 Compounds)

Swissprot:
PLCG2_HUMAN
Stitch:
PLCG2_HUMAN
UniProt:
P16885
ChEMBL:
CHEMBL4100
Reactome:
REACT_118700
REACT_147814
REACT_163834
REACT_163701
REACT_1695
REACT_160158
REACT_150312
REACT_6894
PDB:
2K2J (DOCK)
2W2W (DOCK)
2W2X (DOCK)
PLCG2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 22 15 6 1
Binding ≤ 1μM 3 2 0 0

Reactome Network (8)

Reactome ID Description Species
REACT_118700 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge Homo sapiens
REACT_147814 DAP12 signaling Homo sapiens
REACT_163834 FCERI mediated Ca+2 mobilization Homo sapiens
REACT_163701 FCERI mediated MAPK activation Homo sapiens
REACT_1695 GPVI-mediated activation cascade Homo sapiens
REACT_160158 Role of phospholipids in phagocytosis Homo sapiens
REACT_150312 Synthesis of IP3 and IP4 in the cytosol Homo sapiens
REACT_6894 Toll Like Receptor 4 (TLR4) Cascade Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 3
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

DAP12 signaling

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 3
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 3
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

FCERI mediated Ca+2 mobilization

Uniprot Swissprot Chembl Description Number Shared
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

FCERI mediated MAPK activation

Uniprot Swissprot Chembl Description Number Shared
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

GPVI-mediated activation cascade

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 3
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 3

Role of phospholipids in phagocytosis

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 3
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 3
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

Synthesis of IP3 and IP4 in the cytosol

Uniprot Swissprot Chembl Description Number Shared
PLCB3_HUMAN Q01970 CHEMBL5449 Phospholipase C-beta-3, Human 9
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 2 1 1 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PLCG2-1-E Phospholipase C-gamma-2 (cluster #1 Of 2), Eukaryotic 11 5 5 1
PLCG2-2-E Phospholipase C-gamma-2 (cluster #2 Of 2), Eukaryotic 11 10 1 0
Uniprot Swissprot Chembl Description Number Shared
PLCB3_HUMAN Q01970 CHEMBL5449 Phospholipase C-beta-3, Human 9
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 3
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 3
PK3CA_BOVIN P32871 CHEMBL2498 PI3-kinase P110-alpha Subunit, Bovin 2
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1

Most Common Rings