UCSF

Aldose Reductase, Rat (274 Compounds)

Swissprot:
ALDR_RAT
Stitch:
ALDR_RAT
UniProt:
P07943
ChEMBL:
CHEMBL2622
Reactome:
REACT_248129

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 274 92 48 15
Binding ≤ 1μM 154 39 31 12

Reactome Network (1)

Reactome ID Description Species
REACT_248129 Pregnenolone biosynthesis Rattus norvegicus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 210 42 11 7
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 630 58 22 25
ALDR_PIG P80276 CHEMBL4559 Aldose Reductase, Pig 100 8 6 6

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
ALDR-1-E Aldose Reductase (cluster #1 Of 5), Eukaryotic 907 102 54 18
ALDR-2-E Aldose Reductase (cluster #2 Of 5), Eukaryotic 245 65 6 9
ALDR-3-E Aldose Reductase (cluster #3 Of 5), Eukaryotic 8 0 0 0
ALDR-4-E Aldose Reductase (cluster #4 Of 5), Eukaryotic 21 3 1 1
ALDR-5-E Aldose Reductase (cluster #5 Of 5), Eukaryotic 3 3 2 2
Uniprot Swissprot Chembl Description Number Shared
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 19
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 17
AK1A1_PIG P50578 CHEMBL4049 Aldehyde Reductase, Pig 9
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 8
AK1A1_HUMAN P14550 CHEMBL2246 Aldehyde Reductase, Human 7
AK1BA_HUMAN O60218 CHEMBL5983 Aldo-keto Reductase Family 1 Member B10, Human 5
ALDR_PIG P80276 CHEMBL4559 Aldose Reductase, Pig 5
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 5
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 4
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 4
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 4
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 4
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 4
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 4
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 4
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 3
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 3
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 3
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 3
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 3
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 3
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 2
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 2
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 2
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 2
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 2
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 2
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 2
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 2
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 2
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 2
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 2
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 2
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 2
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 2
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 2
PPBT_RAT P08289 CHEMBL2729 Alkaline Phosphatase Tissue-nonspecific, Rat 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 2
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 2
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
AHR_HUMAN P35869 CHEMBL3201 Aryl Hydrocarbon Receptor, Human 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CD38_HUMAN P28907 CHEMBL4660 Lymphocyte Differentiation Antigen CD38, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
FABI_ECOLI P0AEK4 CHEMBL1857 Enoyl-[acyl-carrier-protein] Reductase, Ecoli 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX1_SOYBN P08170 CHEMBL4586 Seed Lipoxygenase-1, Soybn 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 1
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 1
TOP1_RAT Q9WUL0 CHEMBL1075164 DNA Topoisomerase 1, Rat 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 1

Most Common Rings