UCSF

Beta-lactamase, Ecoli (108 Compounds)

Swissprot:
AMPC_ECOLI
Stitch:
AMPC_ECOLI
UniProt:
P00811
ChEMBL:
CHEMBL2026
PDB:
1C3B (DOCK)
1FCM (DOCK)
1FCN (DOCK)
1FCO (DOCK)
1FSW (DOCK)
1FSY (DOCK)
1GA9 (DOCK)
1I5Q (DOCK)
1IEL (DOCK)
1IEM (DOCK)
1KDS (DOCK)
1KDW (DOCK)
1KE0 (DOCK)
1KE3 (DOCK)
1KE4 (DOCK)
1KVL (DOCK)
1KVM (DOCK)
1L0D (DOCK)
1L0E (DOCK)
1L0F (DOCK)
1L0G (DOCK)
1L2S (DOCK)
1LL5 (DOCK)
1LL9 (DOCK)
1LLB (DOCK)
1MXO (DOCK)
1MY8 (DOCK)
1O07 (DOCK)
1PI4 (DOCK)
1PI5 (DOCK)
1XGI (DOCK)
1XGJ (DOCK)
2BLS (DOCK)
2FFY (DOCK)
2HDQ (DOCK)
2HDR (DOCK)
2HDS (DOCK)
2HDU (DOCK)
2I72 (DOCK)
2P9V (DOCK)
2PU2 (DOCK)
2PU4 (DOCK)
2R9W (DOCK)
2R9X (DOCK)
2RCX (DOCK)
3BLS (DOCK)
3BM6 (DOCK)
3FKV (DOCK)
3FKW (DOCK)
3GQZ (DOCK)
3GR2 (DOCK)
3GRJ (DOCK)
3GSG (DOCK)
3GTC (DOCK)
3GV9 (DOCK)
3GVB (DOCK)
3IWI (DOCK)
3IWO (DOCK)
3IWQ (DOCK)
3IXB (DOCK)
3IXD (DOCK)
3IXG (DOCK)
3IXH (DOCK)
3O86 (DOCK)
3O87 (DOCK)
3O88 (DOCK)

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 108 28 15 16
Binding ≤ 1μM 49 14 12 14

Reactome Network (0)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AMPC_CITFR P05193 CHEMBL1255130 Beta-lactamase, Citfr 7 1 1 1
AMPC_ENTCL P05364 CHEMBL2725 Beta-lactamase, Entcl 108 8 4 5
AMPC_MORMO P94958 CHEMBL5764 Beta-lactamase, Mormo 1 1 1 1
AMPC_PSEAE P24735 CHEMBL5031 Beta-lactamase, Pseae 60 2 2 3

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
AMPC-1-B Beta-lactamase (cluster #1 Of 6), Bacterial 20 13 10 9
AMPC-2-B Beta-lactamase (cluster #2 Of 6), Bacterial 22 8 3 4
AMPC-3-B Beta-lactamase (cluster #3 Of 6), Bacterial 0 0 0 0
AMPC-4-B Beta-lactamase (cluster #4 Of 6), Bacterial 0 0 0 0
AMPC-5-B Beta-lactamase (cluster #5 Of 6), Bacterial 185 8 3 4
AMPC-6-B Beta-lactamase (cluster #6 Of 6), Bacterial 6 4 0 1
Uniprot Swissprot Chembl Description Number Shared
AMPC_ENTCL P05364 CHEMBL2725 Beta-lactamase, Entcl 28
BLAT_ECOLX P62593 CHEMBL2065 Beta-lactamase TEM, Ecolx 23
AMPC_PSEAE P24735 CHEMBL5031 Beta-lactamase, Pseae 9
CTRC_HUMAN Q99895 CHEMBL2386 Chymotrypsin C, Human 8
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 7
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 5
CP51A_HUMAN Q16850 CHEMBL3849 Cytochrome P450 51, Human 5
CP51_MYCTU P0A512 CHEMBL5090 Lanosterol 14-alpha Demethylase, Myctu 5
Q46991_ENTCL Q46991 CHEMBL5219 IMI-1, Entcl 5
BLA1_ECOLX P0AD63 CHEMBL5956 Beta-lactamase SHV-1, Ecolx 4
BLAB_BACFR P25910 CHEMBL4840 Beta-lactamase Type II, Bacfr 4
BLAC_STAAU P00807 CHEMBL4114 Beta-lactamase, Staau 4
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 4
LACTB_HUMAN P83111 CHEMBL3791 Serine Beta-lactamase-like Protein, Human 4
AMPC_CITFR P05193 CHEMBL1255130 Beta-lactamase, Citfr 3
BLAC_BACLI P00808 CHEMBL5633 Beta-lactamase, Bacli 3
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 3
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 3
MDHM_PIG P00346 CHEMBL3444 Malate Dehydrogenase Mitochondrial, Pig 3
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 3
A0ZX81_KLEPN A0ZX81 CHEMBL1255121 Beta-lactamase, Klepn 2
A1E3K9_ECOLX A1E3K9 CHEMBL1075073 Beta-lactamase SCO-1, Ecolx 2
A4KCT8_9ENTR A4KCT8 CHEMBL1075063 Gil1, 9entr 2
A8RR46_BACCS A8RR46 CHEMBL5439 Beta-lactamase, Baccs 2
BLA1_KLEPN P0AD64 CHEMBL5094 Beta-lactamase SHV-1, Klepn 2
BLA1_STEMA P52700 CHEMBL3326 Beta-lactamase L1, Stema 2
BLAB_BACCE P14488 CHEMBL1744488 Beta-lactamase 2, Bacce 2
BLO1_ECOLX P13661 CHEMBL4951 Beta-lactamase OXA-1, Ecolx 2
CP19A_RAT P22443 CHEMBL3859 Cytochrome P450 19A1, Rat 2
D1MIX9_PSEAI D1MIX9 CHEMBL1250341 Beta-lactamase GES-13, Pseai 2
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 2
KPCA_RAT P05696 CHEMBL2855 Protein Kinase C Alpha, Rat 2
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 2
KPCB_RAT P68403 CHEMBL3020 Protein Kinase C Beta, Rat 2
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 2
KPCD3_HUMAN O94806 CHEMBL2595 Protein Kinase C Nu, Human 2
KPCD_RAT P09215 CHEMBL3633 Protein Kinase C Delta, Rat 2
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 2
KPCE_RAT P09216 CHEMBL3424 Protein Kinase C Epsilon, Rat 2
KPCG_HUMAN P05129 CHEMBL2938 Protein Kinase C Gamma, Human 2
KPCG_RAT P63319 CHEMBL3604 Protein Kinase C Gamma, Rat 2
KPCI_HUMAN P41743 CHEMBL2598 Protein Kinase C Iota, Human 2
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 2
KPCL_RAT Q64617 CHEMBL3990 Protein Kinase C Eta, Rat 2
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 2
KPCT_RAT Q9WTQ0 CHEMBL4563 Protein Kinase C Theta, Rat 2
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 2
KPCZ_RAT P09217 CHEMBL5379 Protein Kinase C Zeta, Rat 2
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 2
Q2XPY6_SALET Q2XPY6 CHEMBL1667678 Extended-spectrum Beta-lactamase CTX-M-53, Salet 2
Q50H31_BRAPL Q50H31 CHEMBL1255145 Class D Beta-lactamase, Brapl 2
Q59401_ENTCL Q59401 CHEMBL3499 Beta-lactamase Class C, Entcl 2
Q6GWS8_ECOLX Q6GWS8 CHEMBL5041 Beta-lactamase TEM-125, Ecolx 2
Q6W9J1_ENTCL Q6W9J1 CHEMBL3652 Beta-lactamase TEM, Entcl 2
Q9EXV5_ECOLX Q9EXV5 CHEMBL6131 Beta-lactamase, Ecolx 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
A2RP81_CITFR A2RP81 CHEMBL5303 PER-2 Beta-lactamase, Citfr 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ABCC8_HUMAN Q09428 CHEMBL2071 Sulfonylurea Receptor 1, Human 1
ABCC9_HUMAN O60706 CHEMBL1971 Sulfonylurea Receptor 2, Human 1
ABCC9_RAT Q63563 CHEMBL3244 Sulfonylurea Receptor 2, Rat 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
AMPC_MORMO P94958 CHEMBL5764 Beta-lactamase, Mormo 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
B8R6A5_9BURK B8R6A5 CHEMBL1641339 PenB Class A Beta-lactamase, 9burk 1
BLKPC_KLEPN Q9F663 CHEMBL6132 Carbepenem-hydrolyzing Beta-lactamase KPC, Klepn 1
BLO2_ECOLX P0A1V9 CHEMBL1744485 Beta-lactamase OXA-2, Ecolx 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CLAT_HUMAN P28329 CHEMBL4039 Choline Acetylase, Human 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
CTRB1_HUMAN P17538 CHEMBL4796 Beta-chymotrypsin, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
ENPP2_HUMAN Q13822 CHEMBL3691 Autotaxin, Human 1
GLI1_HUMAN P08151 CHEMBL5461 Zinc Finger Protein GLI1, Human 1
GLI2_HUMAN P10070 CHEMBL5119 Zinc Finger Protein GLI2, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 1
IRK11_HUMAN Q14654 CHEMBL1886 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11, Human 1
IRK11_RAT P70673 CHEMBL3704 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11, Rat 1
IRK8_RAT Q63664 CHEMBL4293 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 8, Rat 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
KAPCA_BOVIN P00517 CHEMBL2654 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Bovin 1
KAPCB_BOVIN P05131 CHEMBL3279 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Bovin 1
KCC2A_HUMAN Q9UQM7 CHEMBL4147 CaM Kinase II Alpha, Human 1
KCC2A_RAT P11275 CHEMBL2359 CaM Kinase II Alpha, Rat 1
KCC2B_HUMAN Q13554 CHEMBL4121 CaM Kinase II Beta, Human 1
KCC2D_HUMAN Q13557 CHEMBL2801 CaM Kinase II Delta, Human 1
KCC2G_HUMAN Q13555 CHEMBL3829 CaM Kinase II Gamma, Human 1
KCNA3_HUMAN P22001 CHEMBL4633 Voltage-gated Potassium Channel Subunit Kv1.3, Human 1
KCND3_HUMAN Q9UK17 CHEMBL1964 Voltage-gated Potassium Channel Subunit Kv4.3, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
KCNN4_HUMAN O15554 CHEMBL4305 Intermediate Conductance Calcium-activated Potassium Channel Protein 4, Human 1
KGP1_BOVIN P00516 CHEMBL3183 CGMP-dependent Protein Kinase 1 Alpha, Bovin 1
KS6A3_HUMAN P51812 CHEMBL2345 Ribosomal Protein S6 Kinase Alpha 3, Human 1
KS6A5_HUMAN O75582 CHEMBL4237 Ribosomal Protein S6 Kinase Alpha 5, Human 1
KS6B1_HUMAN P23443 CHEMBL4501 Ribosomal Protein S6 Kinase 1, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
M3K11_HUMAN Q16584 CHEMBL2708 Mitogen-activated Protein Kinase Kinase Kinase 11, Human 1
M3K9_HUMAN P80192 CHEMBL2872 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 1
MAPK2_HUMAN P49137 CHEMBL2208 MAP Kinase-activated Protein Kinase 2, Human 1
MAPK5_HUMAN Q8IW41 CHEMBL3094 MAP Kinase-activated Protein Kinase 5, Human 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
MYLK_CHICK P11799 CHEMBL3062 Myosin Light Chain Kinase, Smooth Muscle, Chick 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
Q2V0Y6_ECOLX Q2V0Y6 CHEMBL1744490 Beta-lactamase, Ecolx 1
Q4TVR4_KLEPN Q4TVR4 CHEMBL1255144 Beta-lactamase SHV-55, Klepn 1
Q4WNT5_ASPFU Q4WNT5 CHEMBL1681623 14-alpha Sterol Demethylase Cyp51A, Aspfu 1
Q53729_STAAU Q53729 CHEMBL3825 Penicillin-binding Protein 2, Staau 1
Q6JP75_SERFO Q6JP75 CHEMBL5042 Carbapenem-hydrolizing Beta-lactamase SFC-1, Serfo 1
Q72547_9HIV1 Q72547 CHEMBL247 Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
Q96W81_ASPFM Q96W81 CHEMBL1681624 14-alpha Sterol Demethylase, Aspfm 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
SIRT1_HUMAN Q96EB6 CHEMBL4506 NAD-dependent Deacetylase Sirtuin 1, Human 1
SIRT2_HUMAN Q8IXJ6 CHEMBL4462 NAD-dependent Deacetylase Sirtuin 2, Human 1
SIRT3_HUMAN Q9NTG7 CHEMBL4461 NAD-dependent Deacetylase Sirtuin 3, Human 1
TPOR_HUMAN P40238 CHEMBL1864 Thrombopoietin Receptor, Human 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
VGFR1_MOUSE P35969 CHEMBL3516 Vascular Endothelial Growth Factor Receptor 1, Mouse 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 1
Z104295 Z104295 CHEMBL1907601 Cyclin-dependent Kinase 4/cyclin D1 1